Abstract
Endometrial polyps are frequent findings during the evaluation of women suffering from abnormal uterine bleeding (AUB). Endometrial polyps are also frequently detected in women without such symptoms. The widespread use of transvaginal ultrasound (TVUS) and saline infusion sonography (SIS) during gynaecological examination will most likely lead to the diagnosis of endometrial polyps in an increasingly number of asymptomatic women in the future. Consequently, the management of endometrial polyps seems to be a growing clinical issue.
In this chapter, the pathogenesis, diagnosis, symptomatology and treatment of endometrial polyps are described. Furthermore, the risk of malignancy in endometrial polyps is discussed. Finally, clinical guidelines for the treatment of endometrial polyps in pre- and postmenopausal women with or without symptoms are provided.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Abbreviations
- 3D:
-
Three-dimensional
- AUB:
-
Abnormal uterine bleeding
- BMI:
-
Body mass index
- CEUS:
-
Contrast-enhanced ultrasonography
- GF:
-
Growth factors
- GIS:
-
Gel installation sonography
- HT:
-
Hormone therapy
- IGF:
-
Insulin-like growth factor
- IVF:
-
In vitro fertilization
- SHBG:
-
Sex-hormone-binding globulin
- SIS:
-
Saline infusion sonography
- TCRP:
-
Transcervical resection of endometrial polyps
- TVUS:
-
Transvaginal ultrasonography
References
Abbott J, Jansen FW, Lieng M, Tulandi T (2012) AAGL practice report: practice guidelines for the diagnosis and management of endometrial polyps. J Minim Invasive Gynecol 19:3–10
Akkad AA, Habiba MA, Ismail N, Abrams K, Al-Azzawi F (1995) Abnormal uterine bleeding on hormone replacement: the importance of intrauterine structural abnormalities. Obstet Gynecol 86:330–334
Aleem F, Predanic M, Calame R, Moukhtar M, Pennisi J (1995) Transvaginal color and pulsed Doppler sonography of the endometrium: a possible role in reducing the number of dilatation and curettage procedures. J Ultrasound Med 14:139–145
Anastasiadis PG, Koutlaki NG, Skaphida PG, Galazios GC, Tsikouras PN, Liberis VA (2000) Endometrial polyps: prevalence, detection, and malignant potential in women with abnormal uterine bleeding. Eur J Gynaecol Oncol 21:180–183
Antunes A Jr, Costa-Paiva L, Arthuso M, Costa JV, Pinto-Neto AM (2007) Endometrial polyps in pre- and postmenopausal women: factors associated with malignancy. Maturitas 57:415–421
Bakour SH, Khan KS, Gupta JK (2000) The risk of premalignant and malignant pathology in endometrial polyps. Acta Obstet Gynecol Scand 79:317–320
Bakour SH, Gupta JK, Khan KS (2002) Risk factors associated with endometrial polyps in abnormal uterine bleeding. Int J Gynaecol Obstet 76:165–168
Ben-Arie A, Goldchmit C, Laviv Y et al (2004) The malignant potential of endometrial polyps. Eur J Obstet Gynecol Reprod Biol 115:206–210
Bernstein L, Deapen D, Cerhan JR et al (1999) Tamoxifen therapy for breast cancer and endometrial cancer risk. J Natl Cancer Inst 91:1654–1662
Bettocchi S, Nappi L, Ceci O, Selvaggi L (2004a) Office hysteroscopy. Obstet Gynecol Clin North Am 31:641–654
Bettocchi S, Ceci O, Nappi L, Di VR, Masciopinto V, Pansini V et al (2004b) Operative office hysteroscopy without anesthesia: analysis of 4863 cases performed with mechanical instruments. J Am Assoc Gynecol Laparosc 11:59–61
Bokor D, Chambers JB, Rees PJ, Mant TG, Luzzani F, Spinazzi A (2001) Clinical safety of SonoVue, a new contrast agent for ultrasound imaging, in healthy volunteers and in patients with chronic obstructive pulmonary disease. Invest Radiol 36:104–109
Bol S, Wanschura S, Thode B et al (1996) An endometrial polyp with a rearrangement of HMGI-C underlying a complex cytogenetic rearrangement involving chromosomes 2 and 12. Cancer Genet Cytogenet 90:88–90
Bonavolonta G, Rossetti A, Cannella PL, Campo S, Garcea N (1994) Curettage vs. hysteroscopic resection. Minerva Ginecol 46:1–3
Bradley LD (2002) Complications in hysteroscopy: prevention, treatment and legal risk. Curr Opin Obstet Gynecol 14:409–415
Carter J, Saltzman A, Hartenbach E, Fowler J, Carson L, Twiggs LB (1994) Flow characteristics in benign and malignant gynecologic tumors using transvaginal color flow Doppler. Obstet Gynecol 83:125–130
Chalas E, Costantino JP, Wickerham DL, Wolmark N, Lewis GC, Bergman C et al (2005) Benign gynecologic conditions among participants in the Breast Cancer Prevention Trial. Am J Obstet Gynecol 192:1230–1237
Chavez NF, Garner EO, Khan W et al (2002) Does the introduction of new technology change population demographics? Minimally invasive technologies and endometrial polyps. Gynecol Obstet Invest 54:217–220
Clark TJ, Khan KS, Gupta JK (2002) Current practice for the treatment of benign intrauterine polyps: a national questionnaire survey of consultant gynaecologists in UK. Eur J Obstet Gynecol Reprod Biol 103:65–67
Clevenger-Hoeft M, Syrop CH, Stovall DW, Van Voorhis BJ (1999) Sonohysterography in premenopausal women with and without abnormal bleeding. Obstet Gynecol 94:516–520
Coeman D, Van BY, Vanderick G, De Muylder X, De Muylder E, Campo R (1993) Hysteroscopic findings in patients with a cervical polyp. Am J Obstet Gynecol 169:1563–1565
Cohen I (2004) Endometrial pathologies associated with postmenopausal tamoxifen treatment. Gynecol Oncol 94:256–266
Cooper JM, Houck RM, Rigberg HS (1983) The incidence of intrauterine abnormalities found at hysteroscopy in patients undergoing elective hysteroscopic sterilization. J Reprod Med 28:659–661
Cravello L, Stolla V, Bretelle F, Roger V, Blanc B (2000) Hysteroscopic resection of endometrial polyps: a study of 195 cases. Eur J Obstet Gynecol Reprod Biol 93:131–134
Dahmoun M, Boman K, Cajander S, Westin P, Backstrom T (1999) Apoptosis, proliferation, and sex hormone receptors in superficial parts of human endometrium at the end of the secretory phase. J Clin Endocrinol Metab 84:1737–1743
de Kroon CD, Jansen FW (2006) Saline infusion sonography in women with abnormal uterine bleeding: an update of recent findings. Curr Opin Obstet Gynecol 18:653–657
de Kroon CD, de Bock GH, Dieben SW, Jansen FW (2003) Saline contrast hysterosonography in abnormal uterine bleeding: a systematic review and meta-analysis. Br J Obstet Gynaecol 110:938–947
De Muylder X, Neven P, De Somer M, Van Belle Y, Vanderick G, De Muylder E (1991) Endometrial lesions in patients undergoing tamoxifen therapy. Int J Gynaecol Obstet 36:127–130
DeWaay DJ, Syrop CH, Nygaard IE, Davis WA, Van Voorhis BJ (2002) Natural history of uterine polyps and leiomyomata. Obstet Gynecol 100:3–7
Dijkhuizen FP, Brolmann HA, Potters AE, Bongers MY, Heinz AP (1996) The accuracy of transvaginal ultrasonography in the diagnosis of endometrial abnormalities. Obstet Gynecol 87:345–349
Dijkhuizen FP, De Vries LD, Mol BW et al (2000) Comparison of transvaginal ultrasonography and saline infusion sonography for the detection of intracavitary abnormalities in premenopausal women. Ultrasound Obstet Gynecol 15:372–376
Dreisler E, Stampe SS, Ibsen PH, Lose G (2009a) Prevalence of endometrial polyps and abnormal uterine bleeding in a Danish population aged 20–74 years. Ultrasound Obstet Gynecol 33:102–108
Dreisler E, Sorensen SS, Lose G (2009b) Endometrial polyps and associated factors in Danish women aged 36–74 years. Am J Obstet Gynecol 200:147.e1–6
Dreisler E, Sorensen SS, Ibsen PH, Lose G (2009c) Value of endometrial thickness measurement for diagnosing focal intrauterine pathology in women without abnormal uterine bleeding. Ultrasound Obstet Gynecol 33:344–348
Dueholm M, Jensen ML, Laursen H, Kracht P (2001) Can the endometrial thickness as measured by trans-vaginal sonography be used to exclude polyps or hyperplasia in pre-menopausal patients with abnormal uterine bleeding? Acta Obstet Gynecol Scand 80:645–651
Elliott J, Connor ME, Lashen H (2003) The value of outpatient hysteroscopy in diagnosing endometrial pathology in postmenopausal women with and without hormone replacement therapy. Acta Obstet Gynecol Scand 82:1112–1119
Elpek G, Uner M, Elpek GO, Sedele M, Karaveli S (1998) The diagnostic accuracy of the Pipelle endometrial sampler in the presence of endometrial polyps. J Obstet Gynaecol 18:274–275
Englund S, Ingelman-Sundberg A, Westin B (1957) Hysteroscopy in diagnosis and treatment of uterine bleeding. Gynaecologia 143:217–222
Epstein E, Ramirez A, Skoog L, Valentin L (2001) Transvaginal sonography, saline contrast sonohysterography and hysteroscopy for the investigation of women with postmenopausal bleeding and endometrium >5 mm. Ultrasound Obstet Gynecol 18:157–162
Exalto N, Stappers C, van Raamsdonk LA, Emanuel MH (2007) Gel instillation sonohysterography: first experience with a new technique. Fertil Steril 87:152–155
Farrell R, Scurry J, Otton G, Hacker NF (2005) Clinicopathologic review of malignant polyps in stage 1A carcinoma of the endometrium. Gynecol Oncol 98:254–262
Fay TN, Khanem N, Hosking D (1999) Out-patient hysteroscopy in asymptomatic postmenopausal women. Climacteric 2:263–267
Fernandez-Parra J, Rodriguez OA, Lopez CS, Parrilla FF, Montoya VF (2006) Hysteroscopic evaluation of endometrial polyps. Int J Gynaecol Obstet 95:144–148
Ferrazzi E, Zupi E, Leone FP et al (2009) How often are endometrial polyps malignant in asymptomatic postmenopausal women? A multicenter study. Am J Obstet Gynecol 200:235–236
Fleischer AC, Shappell HW (2003) Color Doppler sonohysterography of endometrial polyps and submucosal fibroids. J Ultrasound Med 22:601–604
Frydman R, Eibschitz I, Fernandez H, Hamou J (1987) Uterine evaluation by microhysteroscopy in IVF candidates. Hum Reprod 2:481–485
Gardner FJ, Konje JC, Abrams KR et al (2000) Endometrial protection from tamoxifen-stimulated changes by a levonorgestrel-releasing intrauterine system: a randomised controlled trial. Lancet 356:1711–1717
Gebauer G, Hafner A, Siebzehnrubl E, Lang N (2001) Role of hysteroscopy in detection and extraction of endometrial polyps: results of a prospective study. Am J Obstet Gynecol 184:59–63
Gimpelson RJ, Rappold HO (1988) A comparative study between panoramic hysteroscopy with directed biopsies and dilatation and curettage. A review of 276 cases. Am J Obstet Gynecol 158:489–492
Giordano G, Gnetti L, Merisio C, Melpignano M (2007) Postmenopausal status, hypertension and obesity as risk factors for malignant transformation in endometrial polyps. Maturitas 56:190–197
Goldstein SR, Zeltser I, Horan CK, Snyder JR, Schwartz LB (1997) Ultrasonography-based triage for perimenopausal patients with abnormal uterine bleeding. Am J Obstet Gynecol 177:102–108
Gupta JK, Chien PF, Voit D, Clark TJ, Khan KS (2002) Ultrasonographic endometrial thickness for diagnosing endometrial pathology in women with postmenopausal bleeding: a meta-analysis. Acta Obstet Gynecol Scand 81:799–816
Guven MA, Bese T, Demirkiran F (2004) Comparison of hydrosonography and transvaginal ultrasonography in the detection of intracavitary pathologies in women with abnormal uterine bleeding. Int J Gynecol Cancer 14:57–63
Hann LE, Kim CM, Gonen M, Barakat R, Choi PH, Bach AM (2003) Sonohysterography compared with endometrial biopsy for evaluation of the endometrium in tamoxifen-treated women. J Ultrasound Med 22:1173–1179
Hinckley MD, Milki AA (2004) 1000 office-based hysteroscopies prior to in vitro fertilization: feasibility and findings. JSLS 8:103–107
Iatrakis G, Zervoudis S, Antoniou E, Tsionis C, Pavlou A, Kourounis G et al (2006) Is dosage of hormone replacement therapy related with endometrial polyp formation? Eur J Gynaecol Oncol 27:393–394
Inceboz US, Nese N, Uyar Y et al (2006) Hormone receptor expressions and proliferation markers in postmenopausal endometrial polyps. Gynecol Obstet Invest 61:24–28
Isikoglu M, Berkkanoglu M, Senturk Z, Coetzee K, Ozgur K (2006) Endometrial polyps smaller than 1.5 cm do not affect ICSI outcome. Reprod Biomed Online 12:199–204
Jakab A, Ovari L, Juhasz B, Birinyi L, Bacsko G, Toth Z (2005) Detection of feeding artery improves the ultrasound diagnosis of endometrial polyps in asymptomatic patients. Eur J Obstet Gynecol Reprod Biol 119:103–107
Jansen FW, de Kroon CD, van Dongen H, Grooters C, Louwe L, Trimbos-Kemper T (2006) Diagnostic hysteroscopy and saline infusion sonography: prediction of intrauterine polyps and myomas. J Minim Invasive Gynecol 13:320–324
Kedar RP, Bourne TH, Powles TJ, Collins WP, Ashley SE, Cosgrove DO et al (1994) Effects of tamoxifen on uterus and ovaries of postmenopausal women in a randomised breast cancer prevention trial. Lancet 343:1318–1321
Kim MR, Kim YA, Jo MY, Hwang KJ, Ryu HS (2003) High frequency of endometrial polyps in endometriosis. J Am Assoc Gynecol Laparosc 10:46–48
Krampl E, Bourne T, Hurlen-Solbakken H, Istre O (2001) Transvaginal ultrasonography sonohysterography and operative hysteroscopy for the evaluation of abnormal uterine bleeding. Acta Obstet Gynecol Scand 80:616–622
Kurman RJ (1982) Benign diseases of the endometrium. In: Blaustein A (ed) Pathology of the female genital tract, 2nd edn. Springer, New York/Heidelberg/Berlin, pp 279–310
Lass A, Williams G, Abusheikha N, Brinsden P (1999) The effect of endometrial polyps on outcomes of in vitro fertilization (IVF) cycles. J Assist Reprod Genet 16:410–415
Lieng M, Qvigstad E, Sandvik L, Jørgensen H, Langebrekke A, Istre O (2007) Hysteroscopic resection of symptomatic and asymptomatic endometrial polyps. J Minim Invasive Gynecol 14(2):189–194
Lieng M, Qvigstad E, Dahl GF, Istre O (2008) Flow differences between endometrial polyps and endometrial cancer: a prospective study using contrasted transvaginal color flow Doppler and three-dimensional power Doppler. Ultrasound Obstet Gynecol 32:935–940
Lieng M, Istre O, Sandvik L, Qvigstad E (2009) Prevalence, 1-year regression rate, and clinical significance of asymptomatic endometrial polyps: a cross-sectional study. J Minim Invasive Gynecol 16(4):465–471
Lieng M, Istre O, Sandvik L, Engh V, Qvigstad E (2010a) Clinical effectiveness of transcervical polyp resection in women with endometrial polyps: a randomised controlled trial. J Minim Invasive Gynecol 17:351–357
Lieng M, Istre O, Qvigstad E (2010b) Treatment of endometrial polyps A systematic review. Acta Obstet Gynecol Scand 89:992–1002
Lopes RG, Baracat EC, de Albuquerque Neto LC et al (2007) Analysis of estrogen- and progesterone-receptor expression in endometrial polyps. J Minim Invasive Gynecol 14:300–303
Machtinger R, Korach J, Padoa A et al (2005) Transvaginal ultrasound and diagnostic hysteroscopy as a predictor of endometrial polyps: risk factors for premalignancy and malignancy. Int J Gynecol Cancer 15:325–328
Maia H Jr, Barbosa IC, Marques D, Calmon LC, Ladipo OA, Coutinho EM (1996) Hysteroscopy and transvaginal sonography in menopausal women receiving hormone replacement therapy. J Am Assoc Gynecol Laparosc 4:13–18
Maia H, Maltez A, Athayde C, Coutinho EM (2001) Proliferation profile of endometrial polyps in post-menopausal women. Maturitas 40:273–281
Maia H Jr, Maltez A, Studart E, Athayde C, Coutinho EM (2004a) Ki-67, Bcl-2 and p53 expression in endometrial polyps and in the normal endometrium during the menstrual cycle. BJOG 111:1242–1247
Maia H Jr, Maltez A, Studard E, Athayde C, Coutinho EM (2004b) Effect of previous hormone replacement therapy on endometrial polyps during menopause. Gynecol Endocrinol 18:299–304
Mazur MT, Kurman RJ (2005) Polyps. In: Mazur MT, Kurman RJ (eds) Diagnosis of endometrial biopsies and curettings. A practical approach, 2nd edn. Springer Science and Business Media Inc., New York, pp 163–177
McBean JH, Gibson M, Brumsted JR (1996) The association of intrauterine filling defects on hysterosalpingogram with endometriosis. Fertil Steril 66:522–526
McGurgan P, Taylor LJ, Duffy SR, O’Donovan PJ (2006a) Are endometrial polyps from premenopausal women similar to post-menopausal women? An immunohistochemical comparison of endometrial polyps from pre- and post-menopausal women. Maturitas 54:277–284
McGurgan P, Taylor LJ, Duffy SR, O’Donovan PJ (2006b) Does tamoxifen therapy affect the hormone receptor expression and cell proliferation indices of endometrial polyps? An immunohistochemical comparison of endometrial polyps from postmenopausal women exposed and not exposed to tamoxifen. Maturitas 54:252–259
Merce LT, Alcazar JL, Lopez C, Iglesias E et al (2007) Clinical usefulness of 3-dimensional sonography and power Doppler angiography for diagnosis of endometrial carcinoma. J Ultrasound Med 26:1279–1287
Mertens HJ, Heineman MJ, Evers JL (2002) The expression of apoptosis-related proteins Bcl-2 and Ki67 in endometrium of ovulatory menstrual cycles. Gynecol Obstet Invest 53:224–230
Mittal K, Schwartz L, Goswami S, Demopoulos R (1996) Estrogen and progesterone receptor expression in endometrial polyps. Int J Gynecol Pathol 15:345–348
Mutter GL, Nucci MR, Robboy SJ (2009) Endometritis, metaplasias, polyps and miscellaneous changes. In: Robboy SJ, Mutter GL, Prat J, Bentley RC, Russell P, Anderson MC (eds) Robboy’s pathology of the female reproductive tract, 2nd edn. Churchill Livingstone Elsevier, Edinburgh, pp 343–366
Nappi L, Indraccolo U, Di Spiezio SA, Gentile G, Palombino K, Castaldi MA et al (2009) Are diabetes, hypertension, and obesity independent risk factors for endometrial polyps? J Minim Invasive Gynecol 16:157–162
Nogueira AA, Sant’Ana de Almeida EC, Poli Neto OB, Zambelli Ramalho LN, Rosa e Silva JC, Candido dos Reis FJ (2006) Immunohistochemical expression of p63 in endometrial polyps: evidence that a basal cell immunophenotype is maintained. Menopause 13:826–830
Oguz S, Sargin A, Kelekci S, Aytan H, Tapisiz OL, Mollamahmutoglu L (2005) The role of hormone replacement therapy in endometrial polyp formation. Maturitas 50:231–236
Onalan R, Onalan G, Tonguc E, Ozdener T, Dogan M, Mollamahmutoglu L (2009) Body mass index is an independent risk factor for the development of endometrial polyps in patients undergoing in vitro fertilization. Fertil Steril 91:1056–1060
Orvieto R, Bar-Hava I, Dicker D, Bar J, Ben-Rafael Z, Neri A (1999) Endometrial polyps during menopause: characterization and significance. Acta Obstet Gynecol Scand 78:883–886
Papadia A, Gerbaldo D, Fulcheri E et al (2007) The risk of premalignant and malignant pathology in endometrial polyps: should every polyp be resected? Minerva Ginecol 59:117–124
Parsons AK, Lense JJ (1993) Sonohysterography for endometrial abnormalities: preliminary results. J Clin Ultrasound 21:87–95
Pasqualotto EB, Margossian H, Price LL, Bradley LD (2000) Accuracy of preoperative diagnostic tools and outcome of hysteroscopic management of menstrual dysfunction. J Am Assoc Gynecol Laparosc 7:201–209
Perez-Medina T, Bajo J, Huertas MA, Rubio A (2002) Predicting atypia inside endometrial polyps. J Ultrasound Med 21:125–128
Perez-Medina T, Bajo-Arenas J, Haya J et al (2003) Tibolone and risk of endometrial polyps: a prospective, comparative study with hormone therapy. Menopause 10:534–537
Perez-Medina T, Bajo-Arenas J, Salazar F et al (2005) Endometrial polyps and their implication in the pregnancy rates of patients undergoing intrauterine insemination: a prospective, randomized study. Hum Reprod 20:1632–1635
Perrone G, DeAngelis C, Critelli C, Capri O, Galoppi P, Santoro G et al (2002) Hysteroscopic findings in postmenopausal abnormal uterine bleeding: a comparison between HRT users and non-users. Maturitas 43:251–255
Peterson WF, Novak ER (1956) Endometrial polyps. Obstet Gynecol 8:40–49
Preutthipan S, Herabutya Y (2005) Hysteroscopic polypectomy in 240 premenopausal and postmenopausal women. Fertil Steril 83:705–709
Propst AM, Liberman RF, Harlow BL, Ginsburg ES (2000) Complications of hysteroscopic surgery: predicting patients at risk. Obstet Gynecol 96:517–520
Raine-Fenning NJ, Campbell BK, Clewes JS, Kendall NR, Johnson IR (2003) The reliability of virtual organ computer-aided analysis (VOCAL) for the semiquantification of ovarian, endometrial and subendometrial perfusion. Ultrasound Obstet Gynecol 22:633–639
Reslova T, Tosner J, Resl M, Kugler R, Vavrova I (1999) Endometrial polyps. A clinical study of 245 cases. Arch Gynecol Obstet 262:133–139
Ryan GL, Syrop CH, Van Voorhis BJ (2005) Role, epidemiology, and natural history of benign uterine mass lesions. Clin Obstet Gynecol 48:312–324
Sant’Ana de Almeida EC, Nogueira AA, Candido dos Reis FJ, Zambelli Ramalho LN, Zucoloto S (2004) Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps and adjacent endometrium in postmenopausal women. Maturitas 49:229–233
Savelli L, De IP, Santini D, Rosati F, Ghi T, Pignotti E et al (2003) Histopathologic features and risk factors for benignity, hyperplasia, and cancer in endometrial polyps. Am J Obstet Gynecol 188:927–931
Schlaen I, Bergeron C, Ferenczy A, Wong P, Naves A, Bertoli R (1988) Endometrial polyps: a study of 204 cases. Surg Pathol 262:133–139
Schwarzler P, Concin H, Bosch H, Berlinger A, Wohlgenannt K, Collins WP et al (1998) An evaluation of sonohysterography and diagnostic hysteroscopy for the assessment of intrauterine pathology. Ultrasound Obstet Gynecol 11:337–342
Seinera P, Maccario S, Visentin L, DiGregorio A (1988) Hysteroscopy in an IVF-ER program. Clinical experience with 360 infertile patients. Acta Obstet Gynecol Scand 67:135–137
Shushan A, Revel A, Rojansky N (2004) How often are endometrial polyps malignant? Gynecol Obstet Invest 58:212–215
Sidhu PS, Allan PL, Cattin F et al (2006) Diagnostic efficacy of SonoVue, a second generation contrast agent, in the assessment of extracranial carotid or peripheral arteries using colour and spectral Doppler ultrasound: a multicentre study. Br J Radiol 79:44–51
Smith JJ, Schulman H (1985) Current dilatation and curettage practice: a need for revision. Obstet Gynecol 65:516–518
Stewart CJ, Campbell-Brown M, Critchley HO, Farquharson MA (1999) Endometrial apoptosis in patients with dysfunctional uterine bleeding. Histopathology 34:99–105
Svirsky R, Smorgick N, Rozowski U et al (2008) Can we rely on blind endometrial biopsy for detection of focal intrauterine pathology? Am J Obstet Gynecol 199:115.e1–3
Syrop CH, Sahakian V (1992) Transvaginal sonographic detection of endometrial polyps with fluid contrast augmentation. Obstet Gynecol 79:1041–1043
Tanriverdi HA, Barut A, Gun BD, Kaya E (2004) Is pipelle biopsy really adequate for diagnosing endometrial disease? Med Sci Monit 10:CR271–CR274
Taylor LJ, Jackson TL, Reid JG, Duffy SR (2003) The differential expression of oestrogen receptors, progesterone receptors, Bcl-2 and Ki67 in endometrial polyps. Br J Obstet Gynaecol 110:794–798
Testa AC, Ferrandina G, Fruscella E et al (2005) The use of contrasted transvaginal sonography in the diagnosis of gynecologic diseases: a preliminary study. J Ultrasound Med 24:1267–1278
Timmerman D, Verguts J, Konstantinovic ML et al (2003) The pedicle artery sign based on sonography with color Doppler imaging can replace second-stage tests in women with abnormal vaginal bleeding. Ultrasound Obstet Gynecol 22:166–171
Timmermans A, Gerritse MB, Opmeer BC, Jansen FW, Mol BW, Veersema S (2008) Diagnostic accuracy of endometrial thickness to exclude polyps in women with postmenopausal bleeding. J Clin Ultrasound 36:286–290
van Bogaert LJ (1988) Clinicopathologic findings in endometrial polyps. Obstet Gynecol 71:771–773
Vanni R, Dal CP, Marras S, Moerman P, Andria M, Valdes E et al (1993) Endometrial polyp: another benign tumor characterized by 12q13-q15 changes. Cancer Genet Cytogenet 68:32–33
van Roessel J, Wamsteker K, Exalto N (1987) Sonographic investigation of the uterus during artificial uterine cavity distention. J Clin Ultrasound 15:439–450
Varasteh NN, Neuwirth RS, Levin B, Keltz MD (1999) Pregnancy rates after hysteroscopic polypectomy and myomectomy in infertile women. Obstet Gynecol 94:168–171
Vercellini P, Cortesi I, Oldani S, Moschetta M, De GO, Crosignani PG (1997) The role of transvaginal ultrasonography and outpatient diagnostic hysteroscopy in the evaluation of patients with menorrhagia. Hum Reprod 12:1768–1771
Vilodre LC, Bertat R, Petters R, Reis FM (1997) Cervical polyp as risk factor for hysteroscopically diagnosed endometrial polyps. Gynecol Obstet Invest 44:191–195
Widrich T, Bradley LD, Mitchinson AR, Collins RL (1996) Comparison of saline infusion sonography with office hysteroscopy for the evaluation of the endometrium. Am J Obstet Gynecol 174:1327–1334
Word B, Gravelee LC, Wideman GL (1958) The fallacy of simple uterine curettage. Obstet Gynecol 12:642–648
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lieng, M. (2015). Endometrial Polyps. In: Istre, O. (eds) Minimally Invasive Gynecological Surgery. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44059-9_6
Download citation
DOI: https://doi.org/10.1007/978-3-662-44059-9_6
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-44058-2
Online ISBN: 978-3-662-44059-9
eBook Packages: MedicineMedicine (R0)