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Cancer Immunology pp 93–119Cite as

Role of Cytokines in Tumor Immunity and Immune Tolerance to Cancer

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Abstract

The complex cytokine network at the tumor microenvironment allows a coordinated, effective development of both innate and adaptive antitumor immune responses. While certain cytokines that are produced in the tumor microenvironment can function to inhibit tumor growth, others can promote tumor growth and progression. This chapter reviews the roles of pro-tumor cytokines (TGF-β, IL-17, IL-23, IL-35, and IL-10) that have pathogenic significance in cancer progression and also highlights antitumor cytokines (IL-12 and IL-27) with potential preclinical and clinical applications. A more detailed understanding of tumor-cytokine and immune cell interactions in the tumor microenvironment and thereby manipulating the balance of pro- vs. antitumor cytokines may achieve effective cancer immunotherapy.

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  1. Department of Neurology, Center for Neurologic Diseases, Brigham and Women’s Hospital, Harvard Medical School, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, NRB-641, Boston, MA, 02115, USA

    Murugaiyan Gopal PhD

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  1. Murugaiyan Gopal PhD
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  1. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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Gopal, M. (2015). Role of Cytokines in Tumor Immunity and Immune Tolerance to Cancer. In: Rezaei, N. (eds) Cancer Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44006-3_7

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