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Cancer Immunology pp 61–75Cite as

The Role of Exhaustion in Tumor-Induced T Cell Dysfunction in Cancer

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Abstract

T cells are essential components of the immune system and have been the major focus of immunotherapeutic strategies to boost endogenous antitumor immunity. However, despite homing into tumor sites, infiltrating T cells seldom control tumor growth and T cell-directed immunotherapy has not been successful. Initially, anergy was implicated in the nonresponsiveness of T cells to tumors. Nevertheless, cancer has been hypothesized to be a chronic disease, in a similar fashion to chronic viral infections, where T cells are chronically stimulated. In this scenario, tumor-specific T cells become dysfunctional, progressively losing effector functions, such as cytolysis or cytokine secretion, a phenomenon known as T cell exhaustion. In this chapter, we will review the concept of T cell exhaustion; the mechanisms involved; the markers employed for the identification of exhausted T cells; the evidence for cancer-induced exhaustion, in particular in lung cancer; and the implications of this phenomenon on tumor immunology.

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  1. Departamento de Enfermedades Cronico-Degenerativas, Instituto Nacional de Enfermedades Respiratorias “Ismael Cosío Villegas”, Calzada de Tlalpan 4502, Col. Seccion XVI, Mexico City, Distrito Federal, 14080, Mexico

    Heriberto Prado-Garcia PhD, Susana Romero-Garcia PhD & Jose Sullivan Lopez-Gonzalez PhD

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  1. Heriberto Prado-Garcia PhD
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  2. Susana Romero-Garcia PhD
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  3. Jose Sullivan Lopez-Gonzalez PhD
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Correspondence to Heriberto Prado-Garcia PhD .

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  1. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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Prado-Garcia, H., Romero-Garcia, S., Lopez-Gonzalez, J.S. (2015). The Role of Exhaustion in Tumor-Induced T Cell Dysfunction in Cancer. In: Rezaei, N. (eds) Cancer Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44006-3_5

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