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Cancer Immunology pp 177–194Cite as

Role of Plasmacytoid Dendritic Cells in Cancer

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Abstract

In the last decade several studies provided evidence that plasmacytoid dendritic cells (pDCs) actively participate in a wide spectrum of human diseases including infection, autoimmunity, and cancer. In particular, human neoplasms are populated by pDCs which presence is related to a poor prognosis. However, the role of tumor-associated pDCs (TApDCs) remains controversial. Various studies indicate that pDCs play an immunosuppressive role and facilitate tumor progression in both animal models and humans. In contrast, others found that the presence of activated pDCs results in tumor regression in mice. Given these findings, it is clear that pDC function plays a critical role in tumor biology. Understanding pDC biology in cancer represents an important necessity and will pave the road to novel therapeutic strategies to fight malignancies. In this chapter we will discuss novel findings about the therapeutic tools which are based on the pharmacological manipulation of tumor-associated pDCs.

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Authors and Affiliations

  1. Department of Pharmacy (DIFARMA), University of Salerno, Via Giovanni Paolo II, 132, Fisciano, Salerno, 84084, Italy

    Michela Terlizzi PhD, Aldo Pinto & Rosalinda Sorrentino PhD

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  1. Michela Terlizzi PhD
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  2. Aldo Pinto
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  3. Rosalinda Sorrentino PhD
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Correspondence to Rosalinda Sorrentino PhD .

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  1. Children's Medical Center Hospital, Tehran University of Medical Sciences Research Center for Immunodeficiencies, Tehran, Iran

    Nima Rezaei

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Terlizzi, M., Pinto, A., Sorrentino, R. (2015). Role of Plasmacytoid Dendritic Cells in Cancer. In: Rezaei, N. (eds) Cancer Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44006-3_11

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