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Renal Tumors of Childhood pp 77–99Cite as

Treatment of Wilms Tumor in the Children’s Oncology Group

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Part of the book series: Pediatric Oncology ((PEDIATRICO))

Abstract

The treatment of Wilms tumor (WT) in the Children’s Oncology Group (COG) builds upon the pioneering legacy of the National Wilms Tumor Study Group (NWTS) and findings from other successful cooperative groups, in particular SIOP and the UKCSSG. Five successive NWTS trials have used as their foundation a strategy of up-front nephrectomy and subsequent surgical and pathological staging to dictate risk-adapted therapy and have yielded a population of childhood cancer patients with an overall excellent outcome. The current COG renal tumors committee is conducting clinical trials in WT with aims of reducing long-term toxicity for patients who have good risk disease, intensifying therapies for those with poorer risk disease, and banking biological specimens to assist in the discovery of novel pathways that might be exploited. This chapter summarizes the results of the NWTS over four decades and describes the current COG renal trials as they apply to favorable and unfavorable Wilms and nephroblastomatosis.

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  1. Division of Pediatric Hematology and Oncology Department of Pediatrics and Bioethics, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax, NS, B3K 6R8, Canada

    Conrad Fernandez MD, FRCPC

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Correspondence to Conrad Fernandez MD, FRCPC .

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  1. Department of Developmental Biology and Cancer, Institute of Child Health, University College London, London, United Kingdom

    Kathy Pritchard-Jones

  2. Children's National Medical Center Center for Cancer & Blood Disorders, Washington, District of Columbia, USA

    Jeffrey S. Dome

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Fernandez, C. (2014). Treatment of Wilms Tumor in the Children’s Oncology Group. In: Pritchard-Jones, K., Dome, J. (eds) Renal Tumors of Childhood. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44003-2_5

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  • Print ISBN: 978-3-662-44002-5

  • Online ISBN: 978-3-662-44003-2

  • eBook Packages: MedicineMedicine (R0)

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