Antibacterial Agents



Traditionally, antipseudomonal penicillins combined with an aminoglycoside have been the standard choice for the initial therapy of fever and neutropenia. These regimens were covering primarily Enterobacteriaceae, Pseudomonas aeruginosa, and streptococci. The activity of the former antipseudomonal penicillins (such as carbenicillin, cefsulodin, azlocillin, and ticarcillin) against many Gram-negative rods was, however, rather limited, and the addition of an aminoglycoside was needed to compensate for this limited activity. In the 1980s, ceftazidime was one of the first drugs studied as monotherapy in febrile neutropenia. It was more active in vitro against P. aeruginosa than most of the penicillins and highly active against Escherichia coli and Klebsiella species.


Minimum Inhibitory Concentration Clostridium Difficile Infection Clavulanic Acid Carbapenem Resistance Febrile Neutropenic Patient 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Medicine, Center for Infectious Diseases and Travel Medicine, IFB-Center for Chronic ImmunodeficiencyUniversity HospitalFreiburgGermany

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