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Vesicles and Composite Particles by Rotating Membrane Pore Extrusion

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Upscaling of Bio-Nano-Processes

Part of the book series: Lecture Notes in Bioengineering ((LNBE))

Abstract

We present an innovative processing route based on dynamic membrane pore extrusion and multiphase flow, which allows for the controlled production of particle and core-shell microstructures with tailored techno-functional properties. In the context of MagPro2Life, two scalable continuous processes based on this technology were specifically designed and implemented for the preparation of (i) surface functionalized magnetic composite particles and (ii) functional vesicles, using two respective devices: (i) a novel ROtating MEmbrane Reactor (ROMER) device and (ii) a NAno Membrane Pore EXtruder (NAMPEX) device. Extrusion and detachment of liquid drops and vesicles from pores in a surrounding immiscible continuous fluid phase under various flow conditions like co-flow, flow focusing and cross flow have been studied intensively at our Laboratory of Food process Engineering for a variety of different rheological and interfacial material characteristics within the past decade. Drop- and capsule deformation and breakup were studied in mechanistic detail utilizing in particular microfluidics technology. The coupling of drop/capsule formation with functionalization steps by either entrapment/encapsulation of components for controlled release or surface/interface modification for adjusted and more or less specific adsorption characteristics have been addressed with respect to the overarching goal of the project being the separation of specific protein fractions from soy whey streams.

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Authors and Affiliations

  1. LinkedIn Corporation, Mountain View, CA, USA

    Elisabeth Rondeau, Sebastian Holzapfel, Helen Engel & Erich J. Windhab

Authors
  1. Elisabeth Rondeau
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  2. Sebastian Holzapfel
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  3. Helen Engel
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  4. Erich J. Windhab
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Corresponding author

Correspondence to Elisabeth Rondeau .

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Editors and Affiliations

  1. Institute of Mechanical Process Engineering and Mechanics, Karlsruhe Institute of Technology, Karlsruhe, Germany

    Hermann Nirschl

  2. DuPont, Wilmington, Delaware, USA

    Karsten Keller

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Rondeau, E., Holzapfel, S., Engel, H., Windhab, E.J. (2014). Vesicles and Composite Particles by Rotating Membrane Pore Extrusion. In: Nirschl, H., Keller, K. (eds) Upscaling of Bio-Nano-Processes. Lecture Notes in Bioengineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43899-2_5

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  • DOI: https://doi.org/10.1007/978-3-662-43899-2_5

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  • Online ISBN: 978-3-662-43899-2

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