Abstract
Biologically-derived materials represent one of the most important sources of new technology food and pharmaceutical products due to their precisely controlled structure, biofunctional properties, and potential for inexpensive and sustainable production. Recent advances in a variety of areas of biotechnology, from systems biology to bioreactor technology, have made large-scale production of sophisticated new biomolecular materials possible. However, the costs of producing these exciting new materials can be prohibitive due to separation processing, which typically constitute 80 % of the total cost of production.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Becker JS, Thomas ORT, Franzreb M (2009) Protein separation with magnetic adsorbents in micellar aqueous two-phase systems. Sep Purif Technol 65(1):46–53
Eichholz C et al (2011) Recovery of lysozyme from hen egg white by selective magnetic cake filtration. Eng Life Sci 11(1):75–83
EU (2004) Consequences, opportunities and challenges of modern biotechnology for Europe
Franzreb M et al (2006) Protein purification using magnetic adsorbent particles. Appl Microbiol Biotechnol 70(5):505–516
Hubbuch JJ, Thomas OR (2002) High-gradient magnetic affinity separation of trypsin from porcine pancreatin. Biotechnol Bioeng 79(3):301–313
Hubbuch JJ et al (2001) High gradient magnetic separation versus expanded bed adsorption: a first principle comparison. Bioseparation 10(1–3):99–112
Lindner J, Menzel K, Nirschl H (2013) Parameters influencing magnetically enhanced centrifugation for protein separation. Chem Eng Sci 97:385–393
Ottow K et al (2007) Avoiding proteolysis during fermentation by using high gradient magnetic fishing. J Biotechnol 131(2):S169
Suzuki M et al (1995) Affinity partitioning of protein a using a magnetic aqueous two-phase system. J Ferment Bioeng 80(1):78–84
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Nirschl, H. (2014). Introduction. In: Nirschl, H., Keller, K. (eds) Upscaling of Bio-Nano-Processes. Lecture Notes in Bioengineering. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43899-2_1
Download citation
DOI: https://doi.org/10.1007/978-3-662-43899-2_1
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-43898-5
Online ISBN: 978-3-662-43899-2
eBook Packages: EngineeringEngineering (R0)