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Long Distance Wanderers and the Various Fates of the Neural Crest Cells

  • Werner A. Mueller
  • Monika Hassel
  • Maura Grealy
Chapter

Abstract

In the development of animals extensive cell migrations take place. This applies especially to vertebrate embryos. They are like cities full of tourists. In a translucent fish embryo migratory cells can be seen crawling and swarming. In avian and mammalian blastodiscs the cells of the meso derm’ do not form a ‘skin’ (Greek derma = skin) or a coherent germ ‘layer’; instead the mesodermal cells creep around like amoebae to colonize the spaces between the ectoderm/epiblast and the endoderm/hypoblast towards their target positions and form a loose primary mesenchyme (see Fig.  5.22 fish, Fig.  5.25 bird). Only later they aggregate forming compact structures such as the somites. When the somites split up, the cells of the sclerotome and dermatome emigrate to form compact structures or soft tissues elsewhere (Fig. 15.1). Primordial germ cells, blood cells and neural crest cells travel particularly long distances. Even the germ cells and the cells of the peripheral nervous system as well as the musculature and the skeletal elements of the extremities (fingers, toes) derive from migratory precursors.

Keywords

Germ Cell Dorsal Root Ganglion Neural Crest Colour Pattern Neural Crest Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Dooley CM et al (2013) On the embryonic origin of adult melanophores: the role of ErbB and Kit signalling in establishing melanophore stem cells in zebrafish. Development 140:1003–1013PubMedCrossRefGoogle Scholar
  2. Mongera A et al (2013) Genetic lineage labeling in zebrafish uncovers novel neural crest contributions to the head, including gill pillar cells. Development 140:916–925PubMedCrossRefGoogle Scholar
  3. Le Douarin NM et al (2004) Neural crest cell plasticity and its limits. Development 131:4637–4650PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Werner A. Mueller
    • 1
  • Monika Hassel
    • 2
  • Maura Grealy
    • 3
  1. 1.Centre of Organismal StudiesUniversity of HeidelbergHeidelbergGermany
  2. 2.Spezielle ZoologieUniversität Marburg FB BiologieMarburgGermany
  3. 3.Pharmacology and TherapeuticsNational University of Ireland GalwayGalwayIreland

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