Animal Models of Medication-Related Osteonecrosis of the Jaw

  • Matthew R. Allen


Bisphosphonates have been extensively studied with hundreds of studies describing how they affect various skeletal parameters using animal models. Despite this extensive body of literature, when the clinical description of osteonecrosis of the jaw emerged in 2003/2004, the relative paucity of data describing how bisphosphonates affect the maxillofacial skeletal became clear. Over the past 10 years, there have been several dozen publications showing various aspects of ONJ in mice, rats, dogs, and swine treated with bisphosphonates. Recent work has extended these findings to treatment with RANK-L inhibitors. The establishment of these models will be essential in propelling the field forward to understand the underlying pathophysiology of ONJ and ultimately finding a way to prevent or cure this debilitating condition.


Periodontal Disease Zoledronic Acid Large Animal Model Dental Extraction Exposed Bone 
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Anatomy and Cell BiologyIndiana University School of MedicineIndianapolisUSA

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