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Medication-Related Osteonecrosis of the Jaws pp 131–137Cite as

Histopathology of Medication-Related Osteonecrosis of the Jaw

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Abstract

Osteonecrosis of the jaw in the patients receiving bisphosphonate or denosumab treatment is a serious condition. Despite several terminologies have been used for this condition, bisphosphonate-related osteonecrosis of the jaw (BRONJ) and medication-related osteonecrosis of the jaw (MRONJ) are applied throughout this chapter. BRONJ/MRONJ clinically presents as exposed bone of the mandible or the maxilla with further symptoms such as pain, drainage, or swelling. Histopathological confirmation is strongly recommended to prove the clinical diagnosis whenever surgical intervention is performed. This chapter describes the macroscopic and microscopic features of BRONJ/MRONJ and discusses the histopathologic differential diagnosis of this condition.

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Author information

Authors and Affiliations

  1. Department of Oral Pathology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand

    Risa Chaisuparat DDS, PhD

  2. College of Dental Medicine–Illinois, Midwestern University, Illinois, USA

    Bruno C. Jham DDS, MS, PhD

Authors
  1. Risa Chaisuparat DDS, PhD
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  2. Bruno C. Jham DDS, MS, PhD
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Corresponding author

Correspondence to Risa Chaisuparat DDS, PhD .

Editor information

Editors and Affiliations

  1. Department of Oral and Maxillofacial Sur, Ludwig-Maximilians-University of Munich, Munich, Germany

    Sven Otto

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Chaisuparat, R., Jham, B.C. (2015). Histopathology of Medication-Related Osteonecrosis of the Jaw. In: Otto, S. (eds) Medication-Related Osteonecrosis of the Jaws. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43733-9_12

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  • DOI: https://doi.org/10.1007/978-3-662-43733-9_12

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43732-2

  • Online ISBN: 978-3-662-43733-9

  • eBook Packages: MedicineMedicine (R0)

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