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Microbiology and Antibiotics in the Context of Medication-Related Osteonecrosis of the Jaw

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Medication-Related Osteonecrosis of the Jaws

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Abstract

Microbial infections play a crucial role in the etiology of antiresorptive drug-induced osteonecrosis of the jaw. Numerous reasons are discussed to explain why the bone affected by osteonecrosis of the jaw lacks sufficient healing. Therefore, antibiotics are essential in the treatment of medication-related osteonecrosis of the jaw (MRONJ). Although antibiotic treatment as a singular therapy was able to heal MRONJ only in limited number of cases, it can support disease control. Ideally, antibiotic treatment should be adapted to an antibiogram. Without antibiogram, the antibiotic regime should cover the oral microbial bacteria and the bacteria expected in odontogenic infections. Additional factors have been discussed supporting the idea that bisphosphonates themselves attract bacteria at the bone as certain phyla and species could be found more frequently in osteonecrotic bone when compared to other infections.

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Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, University Hospital Tuebingen, Osianderstrasse 2-8, Tuebingen, BW, Germany

    Sebastian Hoefert DDS, MD

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  1. Sebastian Hoefert DDS, MD
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Correspondence to Sebastian Hoefert DDS, MD .

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Editors and Affiliations

  1. Department of Oral and Maxillofacial Sur, Ludwig-Maximilians-University of Munich, Munich, Germany

    Sven Otto

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Hoefert, S. (2015). Microbiology and Antibiotics in the Context of Medication-Related Osteonecrosis of the Jaw. In: Otto, S. (eds) Medication-Related Osteonecrosis of the Jaws. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43733-9_11

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  • DOI: https://doi.org/10.1007/978-3-662-43733-9_11

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43732-2

  • Online ISBN: 978-3-662-43733-9

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