Skip to main content
SpringerLink
Log in

Keimzelltumoren

  • Chapter
Pädiatrische Hämatologie und Onkologie

Part of the book series: Springer Reference Medizin ((SRM))

  • 7551 Accesses

Zusammenfassung

Keimzelltumoren sind eine heterogene Gruppe von Tumoren, die sich von unreifen primordialen Keimzellen ableiten. Sie entwickeln sich in den Gonaden oder an einer extragonadalen mittelliniennahen Lokalisation. Während im Säuglings- und Kindesalter fast nur Teratome mit unterschiedlichem Unreifegrad, Dottersacktumoren oder Kombinationen von diesen auftreten, werden mit Beginn der Pubertät seminomatöse und andere nichtseminomatöse Keimzelltumoren (embryonales Karzinom, Chorionkarzinom, Dottersacktumor) gesehen, sehr häufig auch als Mischformen. Die Labordiagnostik beinhaltet die Messung der Tumormarker AFP und β-HCG. Die Behandlung erfolgt multimodal und interdisziplinär im Rahmen der aktuellen Therapieoptimierungsprotokolle.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Literatur

  • Albers P, Albrecht W, Algaba F et al. (2015) Guidelines on Testicular Cancer. 2015 Update. European urology 68: 1054–1068

    Google Scholar 

  • Altman RP, Randolph JG, Lilly JR (1974) Sacrococcygeal teratoma: American Academy of Pediatrics Surgical Section Survey 1973. J Ped Surg 9(3): 389–398

    Google Scholar 

  • Badreldin W, Krell J, Chowdhury S et al. (2014) The efficacy of irinotecan, paclitaxel, and oxaliplatin (IPO) in relapsed germ cell tumors with high dose chemotherapy as consolidation – a non-cisplatin-based induction approach. BJU Int, doi: 10.1111/bju.13004

    Google Scholar 

  • Beyer J, Kramar A, Mandanas R et al. (1996) High-dose chemotherapy as salvage treatment in germ cell tumors: a multivariate analysis of prognostic variables. J Clin Oncol 14: 2638–2345

    Google Scholar 

  • Bokemeyer C, Kollmannsberger C, Harstrick A et al. (1999) Treatment of patients with cisplatin-refractory testicular germ-cell cancer. German Testicular Cancer Study Group (GTCSG). Int J Cancer 83: 848–851

    Google Scholar 

  • Cushing B, Giller R, Cullen JW et al. (2004) Randomized comparison of combination chemotherapy with etoposide, bleomycin, and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study – Pediatric Oncology Group 9049 and Children’s Cancer Group 8882. J Clin Oncol 22: 2691–2700

    Google Scholar 

  • De Giorgi U, Rosti G, Slavin S et al. (2005) European Group for Blood and Marrow Transplantation Solid Tumours and Paediatric Disease Working Parties. Salvage high-dose chemotherapy for children with extragonadal germ-cell tumours. Br J Cancer 93(4): 412–417

    Google Scholar 

  • Debes A, Willers R, Göbel U, Wessalowski R (2005) Role of heat treatment in childhood cancers: distinct resistance profiles of solid tumor cell lines towards combined thermochemotherapy. Pediatr Blood Cancer 45: 663–669

    Google Scholar 

  • Einhorn LH, Donohue J (1977) Cisdiamminedichloroplatinum, vinblastine, and bleomycin combination chemotherapy in disseminated testicular cancer. Ann Intern Med 87: 293–298

    Google Scholar 

  • Frazier AL, Hale JP, Rodriguez-Galindo C et al. (2015) Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United kingdom and United States. J Clin Oncol 33(2): 195–201

    Google Scholar 

  • Göbel U, Gutjahr P, Jürgens H et al. (1986) Cooperative therapy study of nontesticular germ cell tumors MAKEI 83 of the Society of Pediatric Oncology: analysis after 3 years. Klin Padiatr 198: 237–244

    Google Scholar 

  • Göbel U, Schneider DT, Calaminus G et al. (2000) Germ-cell tumors in childhood and adolescence. GPOH MAKEI and the MAHO study groups, Review. Ann Oncol 11(3): 263–271

    Google Scholar 

  • Göbel U, Schneider DT, Calaminus G et al. (2001) Multimodal treatment of malignant sacrococcygeal germ cell tumors: a prospective analysis of 66 patients of the german cooperative protocols MAKEI 83/86 and 89. J.Clin.Oncol 19: 1943–1950

    Google Scholar 

  • Göbel U, Kries R von, Teske C et al. (2013a) Brain metastases during follow-up of children and adolescents with extracranial malignant germ cell tumors: risk adapted management decision tree analysis based on data of the MAHO/MAKEI-registry. Pediatr Blood Cancer 60(2): 217–223

    Google Scholar 

  • Göbel U, Hass R, Calaminus G et al. (2013b) Testicular germ cell tumors in boys <10 years: results of the Protocol MAHO 98 in Respect to Surgery and Watch & Wait Strategy. Klin Pädiatr 225: 296–302

    Google Scholar 

  • Göbel U, Calaminus G, Haas R et al. (2014) Testicular germ cell tumors in adolescents– results of the protocol MAHO 98 and the identification of Good Risk Patients. Klin Pädiatr 226: 314–320

    Google Scholar 

  • Haas RJ, Schmidt P, Göbel U, Harms D (1995) Testicular germ cell tumors. Results of the GPO MAHO studies -82, -88, -92. Klin Padiatr 207: 145–150

    Google Scholar 

  • Harms D, Zahn S, Göbel U, Schneider DT (2006a) Pathology and molecular biology of teratomas in childhood and adolescence. Klin Pädiatr 218: 296–302

    Google Scholar 

  • Harms D, Zahn S, Göbel U, Schneider DT (2006b) Pathology and molecular biology of teratomas in childhood and adolescence. Klin Pädiatr 218: 296–302

    Google Scholar 

  • Hawkins EP, Perlman EJ (1996) Germ cell tumors. In: Parham DM (ed) Pediatric neoplasia: Morphology and biology. Lippincott-Raven, Philadelphia

    Google Scholar 

  • Hecher K, Hackeloer BJ (1996) Intrauterine endoscopic laser surgery for fetal sacrococcygeal teratoma. Lancet 347: 470

    Google Scholar 

  • Honecker F, Wermann H, Mayer F et al. (2009) Microsatellite instability, mismatch repair deficiency, and BRAF mutation in treatment-resistant germ cell tumors. J Clin Oncol 27(13): 2129–2136

    Google Scholar 

  • Kaatsch P, Spix C (2014) German Childhood Cancer Registry Report 2013/14 (1980–2013). Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI) at the University Medical Center of the Johannes Gutenberg University, Mainz

    Google Scholar 

  • Mauz-Körholz C, Harms D, Calaminus G, Göbel U (2000) Primary chemotherapy and conservative surgery for vaginal yolk-sac tumour. Maligne Keimzelltumoren Study Group. Lancet 355: 625

    Google Scholar 

  • Mayer F, Gillis AJ, Dinjens W et al. (2002) Microsatellite instability of germ cell tumors is associated with resistance to systemic treatment. Cancer Res 62: 2758–2760

    Google Scholar 

  • Nichols CR (1999) Treatment of recurrent germ cell tumors. Semin Surg Oncol 17: 268–274

    Google Scholar 

  • Nishikawa M, Miyake H, Muramaki M, Fujisawa M (2014) Efficacy and tolerability of TIP (paclitaxel, ifosfamide and cisplatin) incorporated into induction chemotherapy for patients with intermediate- or poor-risk metastatic germ cell tumors. Med Oncol 31(12): 296

    Google Scholar 

  • Oosterhuis JW, Looijenga LH (2005) Testicular germ-cell tumours in a broader perspective. Nat Rev Cancer 5: 210–222

    Google Scholar 

  • Palmer RD, Foster NA, Vowler SL et al. (2007) Malignant germ cell tumours of childhood: new associations of genomic imbalance. Br.J.Cancer 96: 667–676

    Google Scholar 

  • Palmer RD, Barbosa-Morais NL, Gooding EL et al. (2008) Pediatric malignant germ cell tumors show characteristic transcriptome profiles. Cancer Res 68: 4239–4247

    Google Scholar 

  • Palmer RD, Murray MJ, Saini HK et al.; Children’s Cancer and Leukaemia Group (2010) Malignant germ cell tumors display common microRNA profiles resulting in global changes in expression of messenger RNA targets. Cancer Res 70(7): 2911–2923

    Google Scholar 

  • Schmoll HJ, Kollmannsberger C, Metzner B et al. (2003) Long-term results of first-line sequential high-dose etoposide, ifosfamide, and cisplatin chemotherapy plus autologous stem cell support for patients with advanced metastatic germ cell cancer: an extended phase I/II study of the German Testicular Cancer Study Group. J Clin Oncol 21: 4083–4091

    Google Scholar 

  • Schneider DT, Calaminus G, Reinhard H et al. (2000) Primary mediastinal germ cell tumors in children and adolescents: results of the German Cooperative Protocols MAKEI 83/86, 89, and 96. J Clin Oncol 18: 832–839

    Google Scholar 

  • Schneider DT, Wessalowski R, Calaminus G et al. (2001) Treatment of recurrent malignant sacrococcygeal germ cell tumors: analysis of 22 patients registered in the German protocols MAKEI 83/86, 89, and 96. J Clin Oncol 19(7): 1951–1960

    Google Scholar 

  • Schneider DT, Calaminus G, Koch S et al. (2004) Epidemiological analysis of 1442 children and adolescents registered in the German Germ Cell Tumor Protocols. Pediatr Blood Cancer 42: 169–175

    Google Scholar 

  • Sheikh F, Akinkuotu A, Olutoye OO et al. (2015) Prenatally diagnosed neck masses: long-term outcomes and quality of life. J Pediatr Surg 50: 1210–1213

    Google Scholar 

  • Wessalowski R, Schneider DT, Mils O et al.; the MAKEI Study Group (2013) Regional deep hyperthermia for salvage treatment of children and adolescents with refractory or recurrent non-testicular malignant germ-cell tumours: an open-label, non-randomised, single-institution, phase 2 study. Lancet Oncol 14(9): 843–852

    Google Scholar 

  • Zahn S, Sievers S, Alemazkour K et al. (2006) Imbalances of chromosome 1p in pediatric and adult germ cell tumors are caused by true allelic loss:a combined comparative genomic hybridization and microsatellite analysis. Genes Chromosomes. Cancer 45: 995–1006

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Pädiatrische Hämatologie und Onkologie, Universitätsmedizin Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Deutschland

    Dr. med. G. Calaminus

Authors
  1. Dr. med. G. Calaminus
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to G. Calaminus .

Editor information

Editors and Affiliations

  1. Universitätsklinik um Freiburg Zentrum für Kinder- und Jugendmedizin, Freiburg, Deutschland

    Charlotte Niemeyer

  2. Charité-Universitätsmedizin Berlin, Berlin, Deutschland

    Angelika Eggert

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer-Verlag GmbH Deutschland

About this chapter

Cite this chapter

Calaminus, G. (2018). Keimzelltumoren. In: Niemeyer, C., Eggert, A. (eds) Pädiatrische Hämatologie und Onkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43686-8_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-43686-8_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-43685-1

  • Online ISBN: 978-3-662-43686-8

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation