Zusammenfassung
Primäre ZNS-Tumoren sind im Kindes- und Jugendalter mit >20 % nach den Leukämien die zweithäufigste Gruppe aller onkologischen Erkrankungen. Neben der frühzeitigen Diagnosestellung stellt die Versorgung dieser Patienten hohe Anforderungen an ein interdisziplinäres Team. Durch den Einsatz multimodaler Therapiekonzepte liegt die 10-Jahres-Überlebensrate der Gesamtgruppe heute bei 74 %. Dennoch konnte das Überleben einiger Patientengruppen über die letzten 20 Jahre nicht verbessert werden. Durch ein besseres Verständnis der Tumorbiologie ergeben sich gerade für diese Patienten aktuell neue Behandlungsansätze. Die Vermeidung behandlungsbedingter Spätfolgen durch risikoadaptierte Therapiekonzepte gewinnt an Bedeutung. Lokale, nationale und internationale Netzwerke der medizinischen Versorger sowie der translationalen Forschungsgruppen sind Voraussetzung für die weitere Verbesserung der Prognose von Patienten mit ZNS-Tumoren.
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Fleischhack, G. et al. (2018). ZNS-Tumoren. In: Niemeyer, C., Eggert, A. (eds) Pädiatrische Hämatologie und Onkologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43686-8_23
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