The Role of Metronomic Chemotherapy in the Treatment of Metastatic Colorectal Cancer Patients
Neoangiogenesis is a crucial therapeutic target for metastatic colorectal cancer as demonstrated by the effectiveness of biologic drugs with exclusive or partial antiangiogenic activity such as bevacizumab, aflibercept, and regorafenib. Metronomic chemotherapy may be an alternative strategy for targeting tumor angiogenesis and several clinical studies suggested its promising activity and its extremely favorable toxicity profile in the treatment of metastatic colorectal cancer patients.
KeywordsToxicity Shrinkage Anemia Sarcoma Diarrhea
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