Interleukin-10-Producing B Cells and the Regulation of Immunity

  • Ellen Hilgenberg
  • Ping Shen
  • Van Duc Dang
  • Stefanie Ries
  • Imme Sakwa
  • Simon Fillatreau
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 380)


B cells are usually considered primarily for their unique capacity to produce antibodies after differentiation into plasma cells. In addition to their roles as antibody-producing cells, it has become apparent during the last 10 years that B cells also perform important functions in immunity through the production of cytokines. In particular, it was shown that B cells could negatively regulate immunity through provision of interleukin (IL)-10 during autoimmune and infectious diseases in mice. Here, we review data on the suppressive functions of B cells in mice with particular emphasis on the signals controlling the acquisition of such suppressive functions by B cells, the phenotype of the B cells involved in the negative regulation of immunity, and the processes targeted by this inhibitory circuit. Finally, we discuss the possibility that human B cells might also perform similar inhibitory functions through the provision of IL-10, and review data suggesting that such B cell-mediated regulatory activities might be impaired in patients with autoimmune diseases.


Systemic Lupus Erythematosus Ulcerative Colitis Experimental Autoimmune Encephalomyelitis Multiple Sclerosis Patient Marginal Zone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ellen Hilgenberg
    • 1
  • Ping Shen
    • 1
  • Van Duc Dang
    • 1
  • Stefanie Ries
    • 1
  • Imme Sakwa
    • 1
  • Simon Fillatreau
    • 1
  1. 1.Deutsches Rheuma-Forschungszentruma Leibniz InstituteBerlinGermany

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