Interleukin-10-Producing B Cells and the Regulation of Immunity

  • Ellen Hilgenberg
  • Ping Shen
  • Van Duc Dang
  • Stefanie Ries
  • Imme Sakwa
  • Simon Fillatreau
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 380)

Abstract

B cells are usually considered primarily for their unique capacity to produce antibodies after differentiation into plasma cells. In addition to their roles as antibody-producing cells, it has become apparent during the last 10 years that B cells also perform important functions in immunity through the production of cytokines. In particular, it was shown that B cells could negatively regulate immunity through provision of interleukin (IL)-10 during autoimmune and infectious diseases in mice. Here, we review data on the suppressive functions of B cells in mice with particular emphasis on the signals controlling the acquisition of such suppressive functions by B cells, the phenotype of the B cells involved in the negative regulation of immunity, and the processes targeted by this inhibitory circuit. Finally, we discuss the possibility that human B cells might also perform similar inhibitory functions through the provision of IL-10, and review data suggesting that such B cell-mediated regulatory activities might be impaired in patients with autoimmune diseases.

Keywords

Placebo Lymphoma Codon Flare Psoriasis 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Ellen Hilgenberg
    • 1
  • Ping Shen
    • 1
  • Van Duc Dang
    • 1
  • Stefanie Ries
    • 1
  • Imme Sakwa
    • 1
  • Simon Fillatreau
    • 1
  1. 1.Deutsches Rheuma-Forschungszentruma Leibniz InstituteBerlinGermany

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