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Role of IL-22 in Microbial Host Defense

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Book cover Interleukin-10 in Health and Disease

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 380))

Abstract

Interleukin (IL)-22 is a member of the IL-10 family of cytokines, which, besides IL-10, contains seven additional cytokines. Although the founding member IL-10 is an important immunoregulatory cytokine that represses both innate and adaptive immunity, the other family members preferentially target epithelial cells and enhance innate host defense mechanisms against various pathogens such as bacteria, yeast, and viruses. Based on their functions, the IL-10 family can be further divided into three subgroups, IL-10 itself, the IL-20 subfamily, and the IFNλ subfamily. IL-22 is the best-studied member of the IL-20 subfamily, and exemplifies the diverse biological effects of this subfamily. IL-22 elicits various innate immune responses from epithelial cells and is essential for host defense against several invading pathogens, including Citrobacter rodentium and Klebsiella pneumonia. IL-22 also protects tissue integrity and maintains the mucosal homeostasis. On the other hand, IL-22 is a proinflammatory cytokine with the capacity to amplify inflammatory responses, which might result in tissue damage, e.g., the IL-22-dependent necrosis of the small intestine during Toxoplasma gondii infection.

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Authors and Affiliations

  1. Department of Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA, 94080, USA

    Celine Eidenschenk, Sascha Rutz & Wenjun Ouyang

  2. Charite Medical School, Institute for Hygiene and Microbiology, Berlin, 12203, Germany

    Oliver Liesenfeld

  3. Roche Molecular Diagnostics, Pleasanton, CA, USA

    Oliver Liesenfeld

Authors
  1. Celine Eidenschenk
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  2. Sascha Rutz
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  3. Oliver Liesenfeld
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  4. Wenjun Ouyang
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Correspondence to Celine Eidenschenk or Wenjun Ouyang .

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Editors and Affiliations

  1. Deutsches Rheuma-Forschungszentrum Berlin, Berlin, Germany

    Simon Fillatreau

  2. Div. of Immunoregulation, The MRC National Institute for Medical Research, London, United Kingdom

    Anne O'Garra

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Eidenschenk, C., Rutz, S., Liesenfeld, O., Ouyang, W. (2014). Role of IL-22 in Microbial Host Defense. In: Fillatreau, S., O'Garra, A. (eds) Interleukin-10 in Health and Disease. Current Topics in Microbiology and Immunology, vol 380. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43492-5_10

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