Myelodysplastisches Syndrom

  • Thomas Kühne

Zusammenfassung

Die breite Definition des myelodysplastischen Syndroms (MDS; ► Abschn. 5.2) ist allgemein akzeptiert; sobald es jedoch um Details dieser heterogenen Gruppe von Krankheiten und um deren Therapie geht, schwindet die Harmonie. Zudem haben sich die traditionelle Klassifikation (FAB-System) und neuere Nomenklaturen (WHO-Klassifikation) sowie deren Modifikationen für Kinder weniger bewährt als für Erwachsene.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bennett JM, Catkovsky D, Daniel MT et al (1976) Proposals for the classification of the acute leukaemias. French-American-British (FAB) Cooperative Group. Br J Haematol 33:451–458PubMedCrossRefGoogle Scholar
  2. Bennett JM, Catkovsky D, Daniel MT et al (1982) Proposals for the classification of the myelodysplastic syndroms. Br J Haematol 51:189–199PubMedCrossRefGoogle Scholar
  3. Bennett JM, Catkovsky D, Daniel MT et al (1994) The chronic myeloid leukaemias: guidelines for distinguishing chronic granulocytic, atypical chronic myeloid, and chronic myelomonocytic leukaemia. Proposals by the French-American-British Cooperative Leukaemia Group. Br J Haematol 87:746–754PubMedCrossRefGoogle Scholar
  4. Germing U, Aul C, Niemeyer C, Haas R, Bennett JM (2008) Epidemiology, classification and prognosis of adults and children with myelodysplastic syndromes. Ann Hematol 87:691–699PubMedCrossRefGoogle Scholar
  5. Hasle H (1994) Myelodysplastic syndromes in childhood – classification, epidemiology, and treatment. Leuk Lymphoma 13:11–26PubMedCrossRefGoogle Scholar
  6. Hasle H et al (2003) A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases. Leukemia 17:277–282PubMedCrossRefGoogle Scholar
  7. Jaffe ES, Harris NL, Stein H, Vardiman JW (eds) (2001) World Health Organization Classification of Tumours: Pathology and genetics of tumours of haematopoietic and lymphoid tissues. IARC Press, LyonGoogle Scholar
  8. Niemeyer CM, Baumann I (2011) Classification of childhood aplastic anemia and myelodysplastic syndrome. Hematology Am Soc Hematol Educ Program:84–89Google Scholar
  9. Swerdlow SH et al (2008) WHO classification of tumours of haematopoietic and lymphoid tissues. IARC, LyonGoogle Scholar
  10. Vardiman JW (2010) The World Health Organization (WHO) classification of tumors of the hematiopoietic and lymphoid tissues: an overview with emphasis on the myeloid neoplasms. Chem Biol Interact 184:16–20PubMedCrossRefGoogle Scholar
  11. Yin CC, Medeiros LJ, Bueso-Ramos CE (2010) Recent advances in the diagnosis and classification of myeloid neoplasms – comments on the 2008 WHO classification. Int J Lab Hematol 32:461–476PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Thomas Kühne
    • 1
  1. 1.Pädiatrische Onkologie/HämatologieUniversitäts-Kinderspital beider Basel (UKBB)BaselSchweiz

Personalised recommendations