Skip to main content
SpringerLink
Log in
Book cover

S2k-Leitlinie - Labordiagnostik schwangerschaftsrelevanter Virusinfektionen pp 159–169Cite as

Lymphozytäre Choriomeningitis

  • Chapter
  • First Online:

  • 1048 Accesses

Zusammenfassung

Das Virus der lymphozytären Chroriomeningitis (LCMV) ist weltweit verbreitet, infiziert verschiedene Spezies von Wildmäusen und persistiert in diesen. Regional ist die Durchseuchung der Mausspezies unterschiedlich hoch. Die Viren werden im Urin der Tiere ausgeschieden und können auf andere Nagetierspezies (Goldhamster, Renn-/Springmäuse, Chincilla) übertragen werden, wenn diese in der Käfighaltung Kontakt zueinander haben. LCMV kann zoonotisch auf Menschen übertragen werden, die Kontakt mit infizierten Mäusen oder Nagetieren bzw. mit deren Exkrementen (Käfigeinstreu) haben. Die Infektionen verlaufen im Menschen meist ohne oder mit grippeähnlichen Symptomen. Werden Schwangere innerhalb infiziert, so kann die Infektion intrauterin auf deie Feten übertragen werden und eine Embryopathie (Mikroenzephalie) verursachen, die mit Spätfolgen (gesitige Entwicklungsstörungen) verbunden sein kann. Es existiert keine Impfung oder Therapieoption. Eine diagnostische Testung des Infektionsstatus wird nur bei Schwangeren empfohlen, die sehr häufig Kontakt mit potentiell infizierten Nagetieren bzw. deren Exkrementen haben. Die zoonotische Übertragung kann durch entsprechende Hygienemaßnahmen verhindert werden. Akute LCMV-Infektionen bei Schwangeren müssen in Deutschland als Rarität angesehen werden.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   49.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Literatur

  1. Ackermann R, Körver G, Turss R, Wönne R, Hochgesand P (1974) [Prenatal infection with the virus of lymphocytic choriomeningitis: report of two cases (author’s transl)]. Dtsch Med Wochenschr 99(13):629–632

    Article  CAS  PubMed  Google Scholar 

  2. Ackermann R (1977) [Risk to humans through contact with golden hamsters carrying lymphocytic choriomeningitis virus (author’s transl)]. Dtsch Med Wochenschr 102(39):1367–1370

    Article  CAS  PubMed  Google Scholar 

  3. Barton LL, Hyndman NJ (2000) Lymphocytic choriomeningitis virus: reemerging central nervous system pathogen. Pediatrics 2000 Mar;105(3):E35

    Article  CAS  PubMed  Google Scholar 

  4. Barton LL, Mets MB, Beauchamp CL (2002) Lymphocytic choriomeningitis virus: emerging fetal teratogen. Am J Obstet Gynecol 187(6):1715–1716

    Article  PubMed  Google Scholar 

  5. Barton LL, Mets MB (1999) Lymphocytic choriomeningitis virus: pediatric pathogen and fetal teratogen. Pediatr Infect Dis J 18(6):540–541; PubMed PMID: 10391186

    Google Scholar 

  6. Barton LL, Peters CJ, Ksiazek TG (1995) Lymphocytic choriomeningitis virus: an unrecognized teratogenic pathogen. Emerg Infect Dis 1(4):152–153

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Becker SD, Bennett M, Stewart JP, Hurst JL (2003) Serological survey of virus infection among wild house mice (Mus domesticus) in the UK. Lab Anim 2007 Apr;41(2):229–38

    Article  Google Scholar 

  8. Besselsen DG, Wagner AM, Loganbill JK (2003) Detection of lymphocytic choriomeningitis virus by use of fluorogenic nuclease reverse transcriptase-polymerase chain reaction analysis. Comp Med 53(1):65–69

    CAS  PubMed  Google Scholar 

  9. Bonthius DJ, Wright R, Tseng B, Barton L, Marco E et al (2007) Congenital lymphocytic choriomeningitis virus infection: spectrum of disease. Ann Neurol 62(4):347–355

    Article  PubMed  Google Scholar 

  10. Centers for Disease Control and Prevention – CDC (2005) Lymphocytic choriomeningitis virus infection in organ transplant recipients–Massachusetts, Rhode Island, 2005. MMWR Morb Mortal Wkly Rep 54(21):537–539

    Google Scholar 

  11. Centers for Disease Control and Prevention – CDC (2005) Interim guidance for minimizing risk for human lymphocytic choriomeningitis virus infection associated with rodents. MMWR Morb Mortal Wkly Rep 54(30):747–9

    Google Scholar 

  12. Centers for Disease Control and Prevention – CDC (2006) Survey of lymphocytic choriomeningitis virus diagnosis and testing–Connecticut, 2005. MMWR Morb Mortal Wkly Rep 55(14):398–399

    Google Scholar 

  13. Centers for Disease Control and Prevention – CDC (2005) Update: interim guidance for minimizing risk for human lymphocytic choriomeningitis virus infection associated with pet rodents. MMWR Morb Mortal Wkly Rep 54(32):799–801

    Google Scholar 

  14. Childs JE, Glass GE, Korch GW, Ksiazek TG, Leduc JW (1992) Lymphocytic choriomeningitis virus infection and house mouse (Mus musculus) distribution in urban Baltimore. Am J Trop Med Hyg 47(1):27–34

    CAS  PubMed  Google Scholar 

  15. Childs JE, Glass GE, Ksiazek TG, Rossi CA, Oro JG, Leduc JW (1991) Human-rodent contact and infection with lymphocytic choriomeningitis and Seoul viruses in an inner-city population. Am J Trop Med Hyg 44(2):117–121

    CAS  PubMed  Google Scholar 

  16. Cordey S, Sahli R, Moraz ML, Estrade C, Morandi L et al (2011) Analytical validation of a lymphocytic choriomeningitis virus real-time RT-PCR assay. J Virol Methods 177(1):118–122

    Article  CAS  PubMed  Google Scholar 

  17. Deibel R, Woodall JP, Decher WJ, Schryver GD (1975) Lymphocytic choriomeningitis virus in man. Serologic evidence of association with pet hamsters. JAMA 232(5):501–504

    Article  CAS  PubMed  Google Scholar 

  18. de Lamballerie X, Fulhorst CF, Charrel RN (2007) Prevalence of antibodies to lymphocytic choriomeningitis virus in blood donors in southeastern France. Transfusion 47(1):172–173

    Article  PubMed  Google Scholar 

  19. Dobec M, Dzelalija B, Punda-Polic V, Zoric I (2006) High prevalence of antibodies to lymphocytic choriomeningitis virus in a murine typhus endemic region in Croatia. J Med Virol 78(12):1643–1647

    Article  CAS  PubMed  Google Scholar 

  20. Enders G, Varho-Göbel M, Löhler J, Terletskaia-Ladwig E, Eggers M (1999) Congenital lymphocytic choriomeningitis virus infection: an underdiagnosed disease. Pediatr Infect Dis J 18(7):652–655

    Article  CAS  PubMed  Google Scholar 

  21. Foster ES, Signs KA, Marks DR, Kapoor H, Casey M et al (2006) Lymphocytic choriomeningitis in Michigan. Emerg Infect Dis 12(5):851–853

    Article  PubMed Central  PubMed  Google Scholar 

  22. Fritz CL, Fulhorst CF, Enge B, Winthrop KL, Glaser CA, Vugia DJ (2002) Exposure to rodents and rodent-borne viruses among persons with elevated occupational risk. J Occup Environ Med 44(10):962–967

    Article  PubMed  Google Scholar 

  23. Fulhorst CF, Milazzo ML, Armstrong LR, Childs JE, Rollin PE et al (2007) Hantavirus and arenavirus antibodies in persons with occupational rodent exposure. Emerg Infect Dis 13(4):532–538

    Article  PubMed Central  PubMed  Google Scholar 

  24. Greenhow TL, Weintrub PS (2003) Your diagnosis, please. Neonate with hydrocephalus. Pediatr Infect Dis J 22(12):1099, 1111–1112

    Google Scholar 

  25. Hochgesand P, Turss R, Ackermann R (1975) [Prenatal chorio-retinitis transmitted by golden hamsters (author’s transl)]. Klin Monbl Augenheilkd 166(2):190–195

    CAS  PubMed  Google Scholar 

  26. Homberger FR, Romano TP, Seiler P, Hansen GM, Smith AL (1995) Enzyme-linked immunosorbent assay for detection of antibody to lymphocytic choriomeningitis virus in mouse sera, with recombinant nucleoprotein as antigen. Lab Anim Sci 45(5):493–496

    CAS  PubMed  Google Scholar 

  27. Juncker-Voss M, Prosl H, Lussy H, Enzenberg U, Auer H et al (2004) [Screening for antibodies against zoonotic agents among employees of the Zoological Garden of Vienna, Schönbrunn, Austria]. Berl Munch Tierarztl Wochenschr 117(9–10):404–409

    PubMed  Google Scholar 

  28. Kallio-Kokko H, Laakkonen J, Rizzoli A, Tagliapietra V, Cattadori I et al (2006) Hantavirus and arenavirus antibody prevalence in rodents and humans in Trentino, Northern Italy. Epidemiol Infect 134(4):830–836

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  29. Knust B, Macneil A, Wong SJ, Backenson PB, Gibbons A et al (2011) Exposure to lymphocytic choriomeningitis virus, New York, USA. Emerg Infect Dis 17(7):1324–1325

    Article  PubMed Central  PubMed  Google Scholar 

  30. Ledesma J, Fedele CG, Carro F, Lledó L, Sánchez-Seco MP et al (2009) Independent lineage of lymphocytic choriomeningitis virus in wood mice (Apodemus sylvaticus), Spain. Emerg Infect Dis 15(10):1677–1680

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. Marrie TJ, Saron MF (1998) Seroprevalence of lymphocytic choriomeningitis virus in Nova Scotia. Am J Trop Med Hyg 58(1):47–49

    CAS  PubMed  Google Scholar 

  32. Meritet JF, Krivine A, Lewin F, Poissonnier MH, Poizat R et al (2009) A case of congenital lymphocytic choriomeningitis virus (LCMV) infection revealed by hydrops fetalis. Prenat Diagn 29(6):626–627

    Article  CAS  PubMed  Google Scholar 

  33. McIver CJ, Jacques CF, Chow SS, Munro SC, Scott GM et al (2005) Development of multiplex PCRs for detection of common viral pathogens and agents of congenital infections. J Clin Microbiol 43(10):5102–5110

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  34. Mets MB, Barton LL, Khan AS, Ksiazek TG (2000) Lymphocytic choriomeningitis virus: an underdiagnosed cause of congenital chorioretinitis. Am J Ophthalmol 130(2):209–215

    Article  CAS  PubMed  Google Scholar 

  35. Mets MB (1999) Childhood blindness and visual loss: an assessment at two institutions including a "new" cause. Trans Am Ophthalmol Soc 97:653–696

    CAS  PubMed Central  PubMed  Google Scholar 

  36. Moll van Charante AW, Groen J, Osterhaus AD (1994) Risk of infections transmitted by arthropods and rodents in forestry workers. Eur J Epidemiol 10(3):349–351

    Article  Google Scholar 

  37. Park JY, Peters CJ, Rollin PE, Ksiazek TG, Katholi CR et al (1997) Age distribution of lymphocytic choriomeningitis virus serum antibody in Birmingham, Alabama: evidence of a decreased risk of infection. Am J Trop Med Hyg 57(1):37–41

    CAS  PubMed  Google Scholar 

  38. Park JY, Peters CJ, Rollin PE, Ksiazek TG, Gray B et al (1997) Development of a reverse transcription-polymerase chain reaction assay for diagnosis of lymphocytic choriomeningitis virus infection and its use in a prospective surveillance study. J Med Virol 51(2):107–114

    Article  CAS  PubMed  Google Scholar 

  39. Parker JC, Igel HJ, Reynolds RK, Lewis AM Jr, Rowe WP (1976) Lymphocytic choriomeningitis virus infection in fetal, newborn, and young adult Syrian hamsters (Mesocricetus auratus). Infect Immun 13(3):967–981

    CAS  PubMed Central  PubMed  Google Scholar 

  40. Riera L, Castillo E, Del Carmen Saavedra M, Priotto J, Sottosanti J et al (2005) Serological study of the lymphochoriomeningitis virus (LCMV) in an inner city of Argentina. J Med Virol 76(2):285–289

    Article  PubMed  Google Scholar 

  41. Sheinbergas MM, Verikene VV, Maslinskas VY, Lyubetsky VB (1978) Sepcific immunofluorescent IgG, IgM, and IgA antibodies in lymphocytic choriomeningitis. Acta Virol 22(3):218–224

    CAS  PubMed  Google Scholar 

  42. Sheinbergas MM (1975) Antibody to lymphocytic choriomeningitis virus in children with congenital hydrocephalus. Acta Virol 19(2):165–166

    CAS  PubMed  Google Scholar 

  43. Sheinbergas MM (1976) Hydrocephalus due to prenatal infection with the lymphocytic choriomeningitis virus. Infection 4(4):185–191

    Article  CAS  PubMed  Google Scholar 

  44. Skinner HH, Knight EH, Buckley LS (1976) The hamster as a secondary reservoir host of lymphocytic choriomeningitis virus. J Hyg (Lond) 76(2):299–306

    Google Scholar 

  45. Stephensen CB, Blount SR, Lanford RE, Holmes KV, Montali RJ et al (1992) Prevalence of serum antibodies against lymphocytic choriomeningitis virus in selected populations from two U.S. cities. J Med Virol 38(1):27–31

    Article  CAS  PubMed  Google Scholar 

  46. Turković B, Ljubicić M (1992) ELISA and indirect immunofluorescence in the diagnosis of LCM virus infections. Acta Virol 36(6):576–580

    PubMed  Google Scholar 

  47. Vieth S, Drosten C, Lenz O, Vincent M, Omilabu S et al (2007) RT-PCR assay for detection of Lassa virus and related Old World arenaviruses targeting the L gene. Trans R Soc Trop Med Hyg 101(12):1253–1264

    Article  CAS  PubMed  Google Scholar 

  48. Welsh RM, Seedhom MO (2008) Lymphocytic choriomeningitis virus (LCMV): propagation, quantitation, and storage. Curr Protoc Microbiol Chapter 15:Unit 15A.1

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institut für Medizinische Mikrobiologie und Hygiene, Konsilarlabor Parvoviren Universität Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland

    Susanne Modrow

Authors
  1. Susanne Modrow
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Susanne Modrow .

Editor information

Editors and Affiliations

    Rights and permissions

    Reprints and permissions

    Copyright information

    © 2014 DVV, GfV

    About this chapter

    Cite this chapter

    Modrow, S. (2014). Lymphozytäre Choriomeningitis. In: S2k-Leitlinie - Labordiagnostik schwangerschaftsrelevanter Virusinfektionen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43481-9_15

    Download citation

    • DOI: https://doi.org/10.1007/978-3-662-43481-9_15

    • Published:

    • Publisher Name: Springer, Berlin, Heidelberg

    • Print ISBN: 978-3-662-43480-2

    • Online ISBN: 978-3-662-43481-9

    • eBook Packages: Medicine (German Language)

    Publish with us

    Policies and ethics

    Search

    Navigation