Abstract
The origin of intra-ophthalmic artery chemotherapy (SSIOAC) dates back to the 1950s. Cases of advanced intraocular retinoblastoma with (1) large multiple lesions still having enough normal retina so visual preservation was possible, (2) vitreous seeds, or (3) tumors refractory to other treatments presented a challenge for Reese and other early pioneers in the treatment of retinoblastoma, as they unfortunately still do today (Chap. 9).
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References
Reese AB, Hyman GA, Tapley ND, Forrest AW. The treatment of retinoblastoma by x-ray and triethylene melamine. AMA Arch Ophthalmol. 1958;60:897–906.
Kupfer C. Retinoblastoma treated with intravenous nitrogen mustard. Am J Ophthalmol. 1953;36:1721–3.
Retinoblastoma. In: Reese AB, editor. Tumors of the eye. 2nd ed. New York: Harper and Row; p. 84–161.
Kaneko A, Takayama J, Matsuoka H, et al. Chemotherapy was successful in two cases of recurrence of intraocular retinoblastoma after irradiation [in Japanese]. Rinsho Ganka. 1990;44:289–92.
Mohri M. The technique of selective ophthalmic arterial infusion for conservative treatment of recurrent retinoblastoma [in Japanese]. Keio Igaku (J Keio Med Soc). 1993;70:679–87.
Yamane T, Kaneko A, Mohri M. The technique of ophthalmic arterial infusion for patients with intraocular retinoblastoma. Int J Clin Oncol. 2004;9:69–73.
Inomata M, Kaneko A. Chemosensitivity profiles of primary and cultured human retinoblastoma cells in a human tumor clonogenic assay. Jpn J Cancer Res. 1987;78:858–68.
Suzuki S, Yamane T, Mohri M, Kaneko A. Selective ophthalmic artery injection therapy for intraocular retinoblastoma: the long-term prognosis. Ophthalmology. 2011;118:2081–7.
Abramson DH, Dunkel IJ, Brodie SE, et al. A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results. Ophthalmology. 2008;115:1398–404. 1404.e1.
Gobin YP, Dunkel IJ, Marr BP, et al. Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience. Arch Ophthalmol. 2011;129(6):732–7.
Marr BP, Brodie SE, Dunkel IJ, et al. Three-drug intra-arterial chemotherapy using simultaneous carboplatin, topotecan and melphalan for intraocular retinoblastoma: preliminary results. Br J Ophthalmol. 2012;96:1300–3.
Shields CL, Bianciotto CG, Jabbour P, et al. Intra-arterial chemotherapy for retinoblastoma report no. 1, control of retinal tumors, subretinal seeds, and vitreous seeds. Arch Ophthalmol. 2011;129(11):1399–406.
Muen WJ, Kingston JE, Robertson F, et al. Efficacy and complications of super-selective intra-ophthalmic artery melphalan for the treatment of refractory retinoblastoma. Ophthalmology. 2012;119(3):611–6.
Venturi C, Bracco S, Cerase A, et al. Superselective ophthalmic artery infusion of melphalan for intraocular retinoblastoma: preliminary results from 140 treatments. Acta Ophthalmol. 2013;91(4):335–42.
Bracco S, Leonini S, de Francesco S, et al. Intra-arterial chemotherapy with melphalan for intraocular retinoblastoma. Br J Ophthalmol. 2013;97(9):1219–21.
Thampi S, Hetts S, Cooke D, et al. Superselective intra-arterial melphalan therapy for newly diagnosed and refractory retinoblastoma: results from a single institution. Clin Ophthalmol. 2013;7:981–9.
Brodie SE, Gobin YP, Dunkel IJ, et al. Persistence of retinal function after selective ophthalmic artery chemotherapy infusion for retinoblastoma. Doc Ophthalmol. 2009;119:13–22.
Tsimpida M, Thompson DA, Liasis A, et al. Visual outcomes following intraophthalmic artery melphalan for patients with refractory retinoblastoma and age appropriate vision. Br J Ophthalmol. 2013;97:1464–70.
Munier FL, Beck-Popovic M, Balmer A, et al. Occurrence of sectoral choroidal occlusive vasculopathy and retinal arteriolar embolization after ophthalmic artery chemotherapy for advanced intraocular retinoblastoma. Retina. 2011;31(3):566–73.
Shields CL, Shields JA. Retinoblastoma management: advances in enucleation, intravenous chemoreduction, and intra-arterial chemotherapy. Curr Opin Ophthalmol. 2010;21(3):203–12.
Vajzovic LM, Murray TG, Aziz-Sultan MA. Supraselective intra-arterial chemotherapy: evaluation of treatment related complications in advanced retinoblastoma. Clin Ophthalmol. 2011;5:171–6.
Shields CL, Bianciotto CG, Jabbour P, et al. Intra-arterial chemotherapy for retinoblastoma: report no. 2, treatment complications. Arch Ophthalmol. 2011;129(11):1407–15.
Fallaha N, Dubois J, Carret AS, et al. Real-time ophthalmoscopic findings of intraophthalmic artery chemotherapy in retinoblastoma. Arch Ophthalmol. 2012;130:1075–7.
Eagle RC, Shields CL, Bianciotto C, et al. Histopathologic observations after intra-arterial chemotherapy for retinoblastoma. Arch Ophthalmol. 2011;129(11):1416–21.
Vajzovic LM, Murray TG, Aziz-Sultan MA, et al. Clinicopathologic review of enucleated eyes after intra-arterial chemotherapy with melphalan for advanced retinoblastoma. Arch Ophthalmol. 2010;128(12):1619–23.
Graeber CP, Gobin YP, Marr BP, et al. Histopathologic findings of eyes enucleated after treatment with chemosurgery for retinoblastoma. Open Ophthalmol J. 2011;5:1–5.
Kim J, Do H, Egbert P. Enucleated eyes after failed intra-arterial infusion of chemotherapy for unilateral retinoblastoma: histopathologic evaluation of vitreous seeding. Clin Ophthalmol. 2011;5:1655–8.
Samuels BL, Bitran JD. High-dose intravenous melphalan: a review. J Clin Oncol. 1995;13:1786–99.
Wilson MW, Haik BG, Dyer MA. Superselective intraophthalmic artery chemotherapy what we do not know. Arch Ophthalmol. 2011;129(11):1490–1.
Wilson MW, Jackson JS, Phillips BX, et al. Real-time ophthalmoscopic findings of superselective intraophthalmic artery chemotherapy in a nonhuman primate model. Arch Ophthalmol. 2011;129(11):1458–65.
Tse BC, Steinle JJ, Johnson D, et al. Superselective intraophthalmic artery chemotherapy in a nonhuman primate model. JAMA Ophthalmol. 2013;131(7):903–11.
Wilson MW, Qaddoumi I, Billups C, et al. A clinic-pathological correlation of 67 eyes primarily enucleated for advanced intraocular retinoblastoma. Br J Ophthalmol. 2011;95(4):553–8.
Jabbour P, Chalouhi N, Tjoumakaris S. Pearls and pitfalls of intraarterial chemotherapy for retinoblastoma: a review. J Neurosurg Pediatr. 2012;10:127–81.
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Tse, B.C., Brennan, R.C., Wilson, M.W. (2015). Intra-ophthalmic Artery Chemotherapy for Retinoblastoma. In: Singh, A., Murphree, A., Damato, B. (eds) Clinical Ophthalmic Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43451-2_12
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DOI: https://doi.org/10.1007/978-3-662-43451-2_12
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