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The Orbit, Including the Lacrimal Gland and Lacrimal Drainage System

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Eye Pathology

Abstract

This chapter describes the diseases of the orbit, lacrimal gland, and the lacrimal drainage system. The embryology and anatomy of these structures is described shortly. All disease processes are discussed subsequently: congenital abnormalities, inflammation and infection, degenerations, and neoplasms. In order to prevent doublures, certain disease processes and diseases are described in detail as orbital diseases which may be subsequently referred to in the paragraphs of the lacrimal gland and drainage system.

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References

  1. Barishak YR. Embryology of the eye and its adnexae. 2, revised edth ed. Freiburg: Karger; 2001. p. 132.

    Google Scholar 

  2. Jones KL, Higginbottom MC, Smith DW. Determining role of the optic vesicle in orbital and periocular development and placement. Pediatr Res. 1980;14(5):703–8.

    CAS  PubMed  Google Scholar 

  3. de Haan AB, et al. The prenatal development of the human orbit. Strabismus. 2006;14(1):51–6.

    PubMed  Google Scholar 

  4. Johnston MC, et al. Origins of avian ocular and periocular tissues. Exp Eye Res. 1979;29(1):27–43.

    CAS  PubMed  Google Scholar 

  5. Le Lievre CS, Le Douarin NM. Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos. J Embryol Exp Morph. 1975;34(1):125–54.

    PubMed  Google Scholar 

  6. Johnston MC, Bhakdinaronk A, Reid YC. An expanded role of the neural crest in oral and pharyngeal development. Symp Oral Sens Percept. 1973;4:37–52.

    PubMed  Google Scholar 

  7. Johnston MC. A radioautographic study of the migration and fate of cranial neural crest cells in the chick embryo. Anat Rec. 1966;156(2):143–55.

    CAS  PubMed  Google Scholar 

  8. Osanai H, et al. Human orbital muscle: a new point of view from the fetal development of extraocular connective tissues. Invest Ophthalmol Vis Sci. 2010;52(3):1501–6.

    Google Scholar 

  9. Fries PD, Katowitz JA. Congenital craniofacial anomalies of ophthalmic importance. Surv Ophthalmol. 1990;35(2):87–119.

    CAS  PubMed  Google Scholar 

  10. Koornneef L. The development of the connective tissue in the human orbit. Acta Morph Neerl Scand. 1976;14(4):263–90.

    CAS  Google Scholar 

  11. Koornneef L. Orbital septa: anatomy and function. Ophthalmology. 1979;86(5):876–80.

    CAS  PubMed  Google Scholar 

  12. Koornneef L. New insights in the human orbital connective tissue. Result of a new anatomical approach. Arch Ophthalmol. 1977;95(7):1269–73.

    CAS  PubMed  Google Scholar 

  13. Koornneef L. Details of the orbital connective tissue system in the adult. Acta Morph Neerlandica Scand. 1977;15(1):1–34.

    CAS  Google Scholar 

  14. Koornneef L. Eyelid and orbital fascial attachments and their clinical significance. Eye (Lond). 1988;2(Pt 2):130–4.

    Google Scholar 

  15. Henderson JW, et al. Orbital cysts. In: Henderson JW, editor. Orbital tumors. Philadelphia: W.B. Saunders; 1973. p. 86–123.

    Google Scholar 

  16. Shields JA, Shields CL. Orbital cysts of childhood–classification, clinical features, and management. Surv Ophthalmol. 2004;49(3):281–99.

    PubMed  Google Scholar 

  17. West JA, Drewe RH, McNab AA. Atypical choristomatous cysts of the orbit. Aust N Z J Ophthalmol. 1997;25(2):117–23.

    CAS  PubMed  Google Scholar 

  18. von Domarus H. A lacrimal gland cyst in the orbit. J Craniomaxillofac Surg. 1987;15(2):106–9.

    Google Scholar 

  19. Suh MH, et al. Osseous choristoma of an extraocular muscle. J AAPOS. 2008;12(1):83–4.

    PubMed  Google Scholar 

  20. Iliff WJ, Green WR. Orbital tumors in children. In: Jakobiec FA, editor. Ocular and adnexal tumors. Birmingham: Aesculapium Publishing Company; 1978. p. 669–84.

    Google Scholar 

  21. Moon JH, et al. Bilateral ocular osseous choristomas. Pediatr Radiol. 2005;35(11):1145–6.

    PubMed  Google Scholar 

  22. Wolter JR, Roosenberg RJ. Ectopic lymph node of the orbit simulating a lacrimal gland tumor. Am J Ophthalmol. 1977;83(6):908–14.

    CAS  PubMed  Google Scholar 

  23. Wang H, et al. Ectopic pituitary adenoma in the spheno-orbital region. J Neuroophthalmol. 2010;30(2):135–7.

    CAS  PubMed  Google Scholar 

  24. Rootman J. Diseases of the orbit: a multidisciplinary approach. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2003. p. 579.

    Google Scholar 

  25. Karcioğlu ZA. Orbital tumors: diagnosis and treatment. 1st ed. New York: Springer; 2005.

    Google Scholar 

  26. Weill A, et al. Embolization of an orbital varix after surgical exposure. AJNR Am J Neuroradiol. 1998;19(5):921–3.

    CAS  PubMed  Google Scholar 

  27. Porges Y, et al. Hereditary microphthalmia with colobomatous cyst. Am J Ophthalmol. 1992;114(1):30–4.

    CAS  PubMed  Google Scholar 

  28. Mihora LD, et al. Ectopic orbital brain diagnosed 20 years after symptomatic presentation. Orbit. 2009;28(2–3):185–7.

    PubMed  Google Scholar 

  29. Islam N, et al. Orbital varices, cranial defects, and encephaloceles: an unrecognized association. Ophthalmology. 2004;111(6):1244–7.

    PubMed  Google Scholar 

  30. Chan JK. Inflammatory pseudotumor: a family of lesions of diverse nature and aetiologies. Adv Anat Pathol. 1996;3(3):156–71.

    Google Scholar 

  31. Manschot WA. Coenurus infestation of eye and orbit. Arch Ophthalmol. 1976;94(6):961–4.

    CAS  PubMed  Google Scholar 

  32. Brihaye M, et al. Hydatid cyst of the orbit. Bull Soc Belge Ophtalmol. 1967;146:317–28.

    CAS  PubMed  Google Scholar 

  33. Pushker N, et al. Ocular and orbital cysticercosis. Acta Ophthalmol Scand. 2001;79(4):408–13.

    CAS  PubMed  Google Scholar 

  34. Manschot WA. Intraocular cysticercus. Arch Ophthalmol. 1968;80(6):772–4.

    CAS  PubMed  Google Scholar 

  35. Orihel TC, Eberhard ML. Zoonotic filariasis. Clin Microbiol Rev. 1998;11(2):366–81.

    CAS  PubMed Central  PubMed  Google Scholar 

  36. McNab AA, Wright JE. Orbitofrontal cholesterol granuloma. Ophthalmology. 1990;97(1):28–32.

    CAS  PubMed  Google Scholar 

  37. Fukuta K, Jackson IT. Epidermoid cyst and cholesterol granuloma of the orbit. Br J Plast Surg. 1990;43(5):521–7.

    CAS  PubMed  Google Scholar 

  38. Donker DL, et al. Blepharoptosis and upper eyelid swelling due to lipogranulomatous inflammation caused by silicone oil. Am J Ophthalmol. 2005;140(5):934–6.

    PubMed  Google Scholar 

  39. Witschel H, Geiger K. Paraffin induced sclerosing lipogranuloma of eyelids and anterior orbit following endonasal sinus surgery. Br J Ophthalmol. 1994;78(1):61–5.

    CAS  PubMed Central  PubMed  Google Scholar 

  40. van Steensel L, et al. Orbit-infiltrating mast cells, monocytes, and macrophages produce PDGF isoforms that orchestrate orbital fibroblast activation in Graves’ ophthalmopathy. J Clin Endocrinol Metab. 2012;97(3):E400–8.

    PubMed  Google Scholar 

  41. Soeters MR, et al. Optimal management of Graves orbitopathy: a multidisciplinary approach. Neth J Med. 2011;69(7):302–8.

    CAS  PubMed  Google Scholar 

  42. LeBedis CA, Sakai O. Nontraumatic orbital conditions: diagnosis with CT and MR imaging in the emergent setting. Radiographics. 2008;28(6):1741–53.

    PubMed  Google Scholar 

  43. Yuen SJ, Rubin PA. Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome. Arch Ophthalmol. 2003;121(4):491–9.

    PubMed  Google Scholar 

  44. Yuen SJ, Rubin PA. Idiopathic orbital inflammation: ocular mechanisms and clinicopathology. Ophthalmol Clin N Am. 2002;15(1):121–6.

    Google Scholar 

  45. Belanger C, et al. Inflammatory disorders of the orbit in childhood: a case series. Am J Ophthalmol. 2010;150(4):460–3.

    PubMed  Google Scholar 

  46. Swamy BN, et al. Idiopathic orbital inflammatory syndrome: clinical features and treatment outcomes. Br J Ophthalmol. 2007;91(12):1667–70.

    CAS  PubMed Central  PubMed  Google Scholar 

  47. Rootman J, et al. Idiopathic sclerosing inflammation of the orbit. A distinct clinicopathologic entity. Ophthalmology. 1994;101(3):570–84.

    CAS  PubMed  Google Scholar 

  48. Divatia M, Kim SA, Ro JY. IgG4-related sclerosing disease, an emerging entity: a review of a multi-system disease. Yonsei Med J. 2012;53(1):15–34.

    CAS  PubMed Central  PubMed  Google Scholar 

  49. Cheuk W, Chan JK. IgG4-related sclerosing disease: a critical appraisal of an evolving clinicopathologic entity. Adv Anat Pathol. 2010;17(5):303–32.

    CAS  PubMed  Google Scholar 

  50. Takahira M, et al. IgG4-related chronic sclerosing dacryoadenitis. Arch Ophthalmol. 2007;125(11):1575–8.

    PubMed  Google Scholar 

  51. Wallace ZS, et al. IgG4-related systemic disease as a cause of “idiopathic” orbital inflammation, including orbital myositis, and trigeminal nerve involvement. Surv Ophthalmol. 2012;57(1):26–33.

    PubMed  Google Scholar 

  52. Matsui S, et al. Respiratory involvement in IgG4-related Mikulicz’s disease. Mod Rheumatol. 2011;22(1):31–9.

    PubMed  Google Scholar 

  53. Plaza JA, et al. Orbital inflammation with IgG4-positive plasma cells: manifestation of IgG4 systemic disease. Arch Ophthalmol. 2011;129(4):421–8.

    CAS  PubMed  Google Scholar 

  54. Go H, et al. Ocular adnexal IgG4-related disease: comparative analysis with mucosa-associated lymphoid tissue lymphoma and other chronic inflammatory conditions. Histopathology. 2012;60(2):296–312.

    PubMed  Google Scholar 

  55. Andrew N, Kearney D, Selva D. IgG4-related orbital disease: a meta-analysis and review. Acta Ophthalmol. 2013;91(8):694–700.

    CAS  PubMed  Google Scholar 

  56. Singh K, Rajan KD, Eberhart C. Orbital necrobiotic xanthogranuloma associated with systemic IgG4 disease. Ocul Immunol Inflamm. 2010;18(5):373–8.

    PubMed  Google Scholar 

  57. Mudhar HS, Bhatt R, Sandramouli S. Xanthogranulomatous variant of immunoglobulin G4 sclerosing disease presenting as ptosis, proptosis and eyelid skin plaques. Int Ophthalmol. 2011;31(3):245–8.

    PubMed  Google Scholar 

  58. Kubota T, et al. Ocular adnexal marginal zone B cell lymphoma infiltrated by IgG4-positive plasma cells. J Clin Pathol. 2010;63(12):1059–65.

    PubMed Central  PubMed  Google Scholar 

  59. Sivak-Callcott JA, et al. Adult xanthogranulomatous disease of the orbit and ocular adnexa: new immunohistochemical findings and clinical review. Br J Ophthalmol. 2006;90(5):602–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  60. Jaffe R, et al. Histiocytic and dendritic neoplasms. In: Swerdlow SH, editor. WHO classification of tumours of haematopoietic and lymphoid tissues. Geneva: IARC; 2008. p. 354–5.

    Google Scholar 

  61. Verdijk RM, et al. Raised numbers of IgG4-positive plasma cells are a common histopathological finding in orbital xanthogranulomatous disease. Orbit. 2013; 33(1):17–22.

    Google Scholar 

  62. Jakobiec FA, et al. Periocular xanthogranulomas associated with severe adult-onset asthma. Trans Am Ophthalmol Soc. 1993;91:99–125; discussion 125–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  63. Ugurlu S, Bartley GB, Gibson LE. Necrobiotic xanthogranuloma: long-term outcome of ocular and systemic involvement. Am J Ophthalmol. 2000;129(5):651–7.

    CAS  PubMed  Google Scholar 

  64. Johnson TE, et al. Extensive juvenile xanthogranuloma involving the orbit, sinuses, brain, and subtemporal fossa in a newborn. Ophthal Plast Reconstr Surg. 2010;26(2):133–4.

    PubMed  Google Scholar 

  65. Betts DR, et al. Constitutional balanced chromosomal rearrangements and neoplasm in children. J Pediatr Hematol Oncol. 2001;23(9):582–4.

    CAS  PubMed  Google Scholar 

  66. Woywodt A, Matteson EL. Wegener’s granulomatosis – probing the untold past of the man behind the eponym. Rheumatology (Oxford). 2006;45(10):1303–6.

    CAS  Google Scholar 

  67. Perry SR, Rootman J, White VA. The clinical and pathologic constellation of Wegener granulomatosis of the orbit. Ophthalmology. 1997;104(4):683–94.

    CAS  PubMed  Google Scholar 

  68. Perumal B, et al. Non-infectious orbital vasculitides. Eye (Lond). 2012;26(5):630–9.

    CAS  PubMed Central  Google Scholar 

  69. Ohsie LH, Murchison AP, Wojno TH. Lupus erythematosus profundus masquerading as idiopathic orbital inflammatory syndrome. Orbit. 2012;31(3):181–3.

    PubMed  Google Scholar 

  70. Jordan N, et al. Dacryoadenitis and diffuse orbital inflammation: unusual first presentations of Churg-Strauss syndrome. Orbit. 2011;30(3):160–1.

    PubMed  Google Scholar 

  71. Borruat FX, et al. Orbital infarction syndrome. Ophthalmology. 1993;100(4):562–8.

    CAS  PubMed  Google Scholar 

  72. Demirci H, Christianson MD. Orbital and adnexal involvement in sarcoidosis: analysis of clinical features and systemic disease in 30 cases. Am J Ophthalmol. 2011;151(6):1074–80.e1.

    PubMed  Google Scholar 

  73. Messmer EP, et al. Amputation neuroma of the orbit. Report of two cases and review of the literature. Ophthalmology. 1984;91(11):1420–3.

    CAS  PubMed  Google Scholar 

  74. Schick U, Hassler W. Treatment of deep vascular orbital malformations. Clin Neurol Neurosurg. 2009;111(10):801–7.

    PubMed  Google Scholar 

  75. Knowles 2nd DM, et al. Amyloidosis of the orbit and adnexae. Surv Ophthalmol. 1975;19(6):367–84.

    PubMed  Google Scholar 

  76. Murdoch IE, et al. Primary localised amyloidosis of the orbit. Br J Ophthalmol. 1996;80(12):1083–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  77. Goshe JM, et al. Myeloma-associated orbital amyloidosis. Orbit. 2010;29(5):274–7.

    PubMed  Google Scholar 

  78. Connors LH, et al. Tabulation of human transthyretin (TTR) variants, 2003. Amyloid. 2003;10(3):160–84.

    CAS  PubMed  Google Scholar 

  79. Fletcher CD, Unni KK, Mertens F. Pathology and genetics of tumours of soft tissue and bone. In: Kleihues P, Sobin LH, editors. World Health Organization classification of tumours. Lyon: IARCPress; 2002.

    Google Scholar 

  80. DiNardo LJ, Wetmore RF, Potsic WP. Nodular fasciitis of the head and neck in children. A deceptive lesion. Arch Otolaryngol Head Neck Surg. 1991;117(9):1001–2.

    CAS  PubMed  Google Scholar 

  81. Shields JA, et al. Orbital nodular fasciitis simulating a dermoid cyst in an 8-month-old child. Case report and review of the literature. Ophthal Plast Reconstr Surg. 2001;17(2):144–8.

    CAS  PubMed  Google Scholar 

  82. Tolls RE, Mohr S, Spencer WH. Benign nodular fasciitis originating in Tenon’s capsule. Arch Ophthalmol. 1966;75(4):482–3.

    CAS  PubMed  Google Scholar 

  83. Ferry AP, Sherman SE. Nodular fasciitis of the conjunctiva apparently originating in the fascia bulbi (Tenon’s capsule). Am J Ophthalmol. 1974;78(3):514–7.

    CAS  PubMed  Google Scholar 

  84. Riffle JE, et al. Nodular fasciitis of the orbit: a case report and brief review of the literature. Case Rep Ophthalmol Med. 2011;2011:235956.

    PubMed Central  PubMed  Google Scholar 

  85. Damasceno RW, et al. Nodular fasciitis of the eyelid and anterior orbit in children: case report and review of the literature. Ophthalmologe. 2009;106(9):829–31.

    CAS  PubMed  Google Scholar 

  86. Weiss SW, Goldblum JR. Enzinger & Weiss’s soft tissue tumors. 5th ed. Philadelphia: Mosby; 2008.

    Google Scholar 

  87. Mynatt CJ, Feldman KA, Thompson LD. Orbital infantile myofibroma: a case report and clinicopathologic review of 24 cases from the literature. Head Neck Pathol. 2011;5(3):205–15.

    PubMed Central  PubMed  Google Scholar 

  88. Gatibelza ME, et al. Isolated infantile myofibromatosis of the upper eyelid: uncommon localization and long-term results after surgical management. J Pediatr Surg. 2012;47(7):1457–9.

    PubMed  Google Scholar 

  89. Bloom RI, et al. A case of congenital myofibroma of the orbit presenting at birth. Orbit. 2013;32(1):33–5.

    PubMed  Google Scholar 

  90. Duffy MT, Harris M, Hornblass A. Infantile myofibromatosis of orbital bone. A case report with computed tomography, magnetic resonance imaging, and histologic findings. Ophthalmology. 1997;104(9):1471–4.

    CAS  PubMed  Google Scholar 

  91. Calsina M, et al. Solitary orbital myofibroma: clinical, radiographic, and histopathologic findings. A report of two cases. Orbit. 2011;30(4):180–2.

    PubMed  Google Scholar 

  92. De Wan J, Evens F, De Mey A. Eyelid tumour and juvenile hyaline fibromatosis. Br J Plast Surg. 2005;58(1):106–11.

    PubMed  Google Scholar 

  93. Pushker N, et al. Infantile hemangiopericytoma of the orbit treated with primary chemotherapy. J Pediatr Ophthalmol Strabismus. 2012;49:e23–5.

    PubMed  Google Scholar 

  94. Mentzel T, et al. Infantile hemangiopericytoma versus infantile myofibromatosis. Study of a series suggesting a continuous spectrum of infantile myofibroblastic lesions. Am J Surg Pathol. 1994;18(9):922–30.

    CAS  PubMed  Google Scholar 

  95. Polito E, et al. Inflammatory myofibroblastic tumor of the orbit. Ophthalmologica. 2007;221(5):353–5.

    PubMed  Google Scholar 

  96. Cessna MH, et al. Expression of ALK1 and p80 in inflammatory myofibroblastic tumor and its mesenchymal mimics: a study of 135 cases. Mod Pathol. 2002;15(9):931–8.

    PubMed  Google Scholar 

  97. O’Malley DP, et al. Intraocular inflammatory myofibroblastic tumor with ALK overexpression. Arch Pathol Lab Med. 2004;128(1):e5–7.

    PubMed  Google Scholar 

  98. Sa HS, et al. Inflammatory myofibroblastic tumor of the orbit presenting as a subconjunctival mass. Ophthal Plast Reconstr Surg. 2005;21(3):211–5.

    PubMed  Google Scholar 

  99. Yamamoto H, et al. Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study. Am J Surg Pathol. 2009;33(9):1330–40.

    PubMed  Google Scholar 

  100. Furusato E, et al. Orbital solitary fibrous tumor: encompassing terminology for hemangiopericytoma, giant cell angiofibroma, and fibrous histiocytoma of the orbit: reappraisal of 41 cases. Hum Pathol. 2010;42(1):120–8.

    PubMed  Google Scholar 

  101. Bernardini FP, et al. Solitary fibrous tumor of the orbit: is it rare? Report of a case series and review of the literature. Ophthalmology. 2003;110(7):1442–8.

    PubMed  Google Scholar 

  102. Font RL, Hidayat AA. Fibrous histiocytoma of the orbit. A clinicopathologic study of 150 cases. Hum Pathol. 1982;13(3):199–209.

    CAS  PubMed  Google Scholar 

  103. Hidayat AA, et al. Myxomas and angiomyxomas of the orbit: a clinicopathologic study of 6 cases. Ophthalmology. 2007;114(5):1012–9.

    PubMed  Google Scholar 

  104. Zhang Q, et al. Myxofibrosarcoma of the orbit: a clinicopathologic case report. Ophthal Plast Reconstr Surg. 2010;26(2):129–31.

    PubMed Central  PubMed  Google Scholar 

  105. Russell H, et al. Infantile fibrosarcoma: clinical and histologic responses to cytotoxic chemotherapy. Pediatr Blood Cancer. 2009;53(1):23–7.

    PubMed  Google Scholar 

  106. Bartley GB, et al. Spindle cell lipoma of the orbit. Am J Ophthalmol. 1985;100(4):605–9.

    CAS  PubMed  Google Scholar 

  107. Johnson BL, Linn Jr JG. Spindle cell lipoma of the orbit. Arch Ophthalmol. 1979;97(1):133–4.

    CAS  PubMed  Google Scholar 

  108. Daniel CS, et al. Pleomorphic lipoma of the orbit: a case series and review of literature. Ophthalmology. 2003;110(1):101–5.

    PubMed  Google Scholar 

  109. Dutton JJ, Wright Jr JD. Intramuscular lipoma of the superior oblique muscle. Orbit. 2006;25(3):227–33.

    PubMed  Google Scholar 

  110. Kim MH, et al. Fibrolipoma of the orbit. Ophthal Plast Reconstr Surg. 2011;27(1):e16–8.

    PubMed  Google Scholar 

  111. Farah-Klibi F, et al. Lipomatous hemangiopericytoma (adipocytic variant of solitary fibrous tumor) of the orbit. A case report with review of the literature. Pathologica. 2006;98(6):645–8.

    CAS  PubMed  Google Scholar 

  112. Jakobiec FA, et al. MDM2-positive atypical lipomatous neoplasm/well-differentiated liposarcoma versus spindle cell lipoma of the orbit. Ophthal Plast Reconstr Surg. 2010;26(6):413–5.

    PubMed  Google Scholar 

  113. Madge SN, et al. Primary orbital liposarcoma. Ophthalmology. 2010;117(3):606–14.

    PubMed  Google Scholar 

  114. Shinder R, et al. Primary orbital liposarcoma misdiagnosed as thyroid associated orbitopathy. Orbit. 2012;31(4):264–6.

    PubMed  Google Scholar 

  115. Hannachi Sassi S, et al. Orbital metastasis of liposarcoma. J Fr Ophtalmol. 2007;30(9):e28.

    CAS  PubMed  Google Scholar 

  116. Cai YC, et al. Primary liposarcoma of the orbit: a clinicopathologic study of seven cases. Ann Diagn Pathol. 2001;5(5):255–66.

    CAS  PubMed  Google Scholar 

  117. Ebrahimi KB, Ren S, Green WR. Floretlike cells in in situ and prolapsed orbital fat. Ophthalmology. 2007;114(12):2345–9.

    PubMed  Google Scholar 

  118. Thway K, et al. Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 2012;36(3):462–9.

    PubMed  Google Scholar 

  119. Arat YO, et al. Leiomyoma of the orbit and periocular region: a clinicopathologic study of four cases. Ophthal Plast Reconstr Surg. 2005;21(1):16–22.

    PubMed  Google Scholar 

  120. Fernandes BF, et al. Orbital leiomyoma: histopathologic and immunohistochemical findings of a rare tumor. Ophthal Plast Reconstr Surg. 2009;25(1):59–61.

    PubMed  Google Scholar 

  121. Gunduz K, et al. Orbital leiomyoma: report of a case and review of the literature. Surv Ophthalmol. 2004;49(2):237–42.

    PubMed  Google Scholar 

  122. Chen J, Wei R, Ma X. Orbital metastasis of retroperitoneal leiomyosarcoma. Med Oncol. 2012;29(1):392–5.

    CAS  PubMed  Google Scholar 

  123. Hou LC, Murphy MA, Tung GA. Primary orbital leiomyosarcoma: a case report with MRI findings. Am J Ophthalmol. 2003;135(3):408–10.

    PubMed  Google Scholar 

  124. Klippenstein KA, Wesley RE, Glick AD. Orbital leiomyosarcoma after retinoblastoma. Ophthalmic Surg Lasers. 1999;30(7):579–83.

    CAS  PubMed  Google Scholar 

  125. Li YP, et al. Rhabdomyoma of the orbit. J Pediatr Ophthalmol Strabismus. 2008;45(2):113–5.

    PubMed  Google Scholar 

  126. Stout AP. Rhabdomyosarcoma of the skeletal muscles. Ann Surg. 1946;123(3):447–72.

    PubMed Central  Google Scholar 

  127. Arndt CA, Crist WM. Common musculoskeletal tumors of childhood and adolescence. N Engl J Med. 1999;341(5):342–52.

    CAS  PubMed  Google Scholar 

  128. Newton Jr WA, et al. Histopathology of childhood sarcomas, Intergroup Rhabdomyosarcoma Studies I and II: clinicopathologic correlation. J Clin Oncol. 1988;6(1):67–75.

    PubMed  Google Scholar 

  129. Kodet R, et al. Orbital rhabdomyosarcomas and related tumors in childhood: relationship of morphology to prognosis–an Intergroup Rhabdomyosarcoma study. Med Pediatr Oncol. 1997;29(1):51–60.

    CAS  PubMed  Google Scholar 

  130. Polito E, et al. A case of primary botryoid conjunctival rhabdomyosarcoma. Graefes Arch Clin Exp Ophthalmol. 2006;244(4):517–9.

    PubMed  Google Scholar 

  131. Qualman SJ, et al. Intergroup Rhabdomyosarcoma Study: update for pathologists. Pediatr Dev Pathol. 1998;1(6):550–61.

    CAS  PubMed  Google Scholar 

  132. Chaves E. Pleomorphic rhabdomyosarcoma of the orbit. Presentation of a case. Rev Bras Oftalmol. 1967;26(1):73–82.

    CAS  PubMed  Google Scholar 

  133. Furlong MA, Fanburg-Smith JC. Pleomorphic rhabdomyosarcoma in children: four cases in the pediatric age group. Ann Diagn Pathol. 2001;5(4):199–206.

    CAS  PubMed  Google Scholar 

  134. Furlong MA, Mentzel T, Fanburg-Smith JC. Pleomorphic rhabdomyosarcoma in adults: a clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol. 2001;14(6):595–603.

    CAS  PubMed  Google Scholar 

  135. Sullivan LM, Atkins KA, LeGallo RD. PAX immunoreactivity identifies alveolar rhabdomyosarcoma. Am J Surg Pathol. 2009;33(5):775–80.

    PubMed  Google Scholar 

  136. Barr FG. Molecular genetics and pathogenesis of rhabdomyosarcoma. J Pediatr Hematol Oncol. 1997;19(6):483–91.

    CAS  PubMed  Google Scholar 

  137. Sumegi J, et al. Recurrent t(2;2) and t(2;8) translocations in rhabdomyosarcoma without the canonical PAX-FOXO1 fuse PAX3 to members of the nuclear receptor transcriptional coactivator family. Genes Chromosome Cancer. 2010;49(3):224–36.

    CAS  Google Scholar 

  138. Punyko JA, et al. Long-term survival probabilities for childhood rhabdomyosarcoma. A population-based evaluation. Cancer. 2005;103(7):1475–83.

    PubMed  Google Scholar 

  139. Ulivieri S, et al. Orbital glomangioma. Orbit. 2012;31(4):216–8.

    PubMed  Google Scholar 

  140. Granter SR, Badizadegan K, Fletcher CD. Myofibromatosis in adults, glomangiopericytoma, and myopericytoma: a spectrum of tumors showing perivascular myoid differentiation. Am J Surg Pathol. 1998;22(5):513–25.

    CAS  PubMed  Google Scholar 

  141. Rosca TI, et al. Vascular tumors in the orbit–capillary and cavernous hemangiomas. Ann Diagn Pathol. 2006;10(1):13–9.

    PubMed  Google Scholar 

  142. Acocella A, Catelani C, Nardi P. Angiolymphoid hyperplasia with eosinophilia: a case report of orbital involvement. J Oral Maxillofac Surg. 2005;63(1):140–4.

    PubMed  Google Scholar 

  143. Seregard S. Angiolymphoid hyperplasia with eosinophilia should not be confused with Kimura’s disease. Acta Ophthalmol Scand. 2001;79(1):91–3.

    CAS  PubMed  Google Scholar 

  144. Lopes M, Duffau H, Fleuridas G. Primary spheno-orbital angiosarcoma: case report and review of the literature. Neurosurgery. 1999;44(2):405–7; discussion 407–8.

    CAS  PubMed  Google Scholar 

  145. Lyon DB, Tang TT, Kidder TM. Epithelioid hemangioendothelioma of the orbital bones. Ophthalmology. 1992;99(12):1773–8.

    CAS  PubMed  Google Scholar 

  146. Kivela T, Tarkkanen A. Orbital germ cell tumors revisited: a clinicopathological approach to classification. Surv Ophthalmol. 1994;38(6):541–54.

    CAS  PubMed  Google Scholar 

  147. Oosterhuis JW, et al. Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives. Int J Androl. 2007;30(4):256–63; discussion 263–4.

    PubMed  Google Scholar 

  148. Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of the ovary: a clinical and pathologic study of 58 cases. Cancer. 1976;37(5):2359–72.

    CAS  PubMed  Google Scholar 

  149. Gonzalez-Crussi F. Extragonadal teratomas. In: Hartmann WH, editor. Atlas of tumor pathology. 2nd ed. Washington, DC: Armed Forces Institute of Pathology; 1982.

    Google Scholar 

  150. Bernoulli R. On a primary teratoid sarcoma of the orbit. Opt Acta Lond. 1962;143:370–7.

    CAS  PubMed  Google Scholar 

  151. Mahesh L, et al. Malignant teratoma of the orbit: a clinicopathological study of a case. Orbit. 2003;22(4):305–9.

    PubMed  Google Scholar 

  152. Soares E, da Silva Lopes K, de Souza Andrade J. Orbital malignant teratoma. A case report. Orbit. 1983;2:235–42.

    Google Scholar 

  153. Garden JW, McManis JC. Congenital orbital-intracranial teratoma with subsequent malignancy: case report. Br J Ophthalmol. 1986;70(2):111–3.

    CAS  PubMed Central  PubMed  Google Scholar 

  154. Ogun OA, et al. Congenital orbital teratoma: a case report and challenges of its management in a resource limited setting. Pan Afr Med J. 2012;12:3.

    PubMed Central  PubMed  Google Scholar 

  155. O’Connor DM, Norris HJ. The influence of grade on the outcome of stage I ovarian immature (malignant) teratomas and the reproducibility of grading. Int J Gynecol Pathol. 1994;13(4):283–9.

    PubMed  Google Scholar 

  156. Kiratli H, Erkan Balci K, Guler G. Primary orbital endodermal sinus tumor (yolk sac tumor). J AAPOS. 2008;12(6):623–5.

    PubMed  Google Scholar 

  157. Margo CE, et al. Endodermal sinus tumor (yolk sac tumor) of the orbit. Ophthalmology. 1983;90(12):1426–32.

    CAS  PubMed  Google Scholar 

  158. Perrini P, et al. Primary germinoma of the orbit. Neurosurgery. 2005;57(4):E813.

    PubMed  Google Scholar 

  159. Altan-Yaycioglu R, Hintschich C. Clinical features and surgical management of orbitotemporal neurofibromatosis: a retrospective interventional case series. Orbit. 2010;29(5):232–8.

    PubMed  Google Scholar 

  160. Singhal D, et al. Soft tissue management of orbitotemporal neurofibromatosis. J Craniofac Surg. 2013;24(1):269–72.

    PubMed  Google Scholar 

  161. Spencer WH. Ophthalmic Pathology: An Atlas and Textbook, 4th edition. Philadelphia: W.B. Saunders; 1996. p. 125–155.

    Google Scholar 

  162. Pecorella I, Toth J, Lukats O. Ancient schwannoma of the orbit. Pathologica. 2012;104(4):182–4.

    CAS  PubMed  Google Scholar 

  163. Dolman PJ, Rootman J, Dolman CL. Infiltrating orbital granular cell tumour: a case report and literature review. Br J Ophthalmol. 1987;71(1):47–53.

    CAS  PubMed Central  PubMed  Google Scholar 

  164. Poyraz CE, Kiratli H, Soylemezoglu F. Granular cell tumor of the inferior rectus muscle. Korean J Ophthalmol. 2009;23(1):43–5.

    PubMed Central  PubMed  Google Scholar 

  165. Romero-Rojas AE, Diaz-Perez JA, Lozano-Castillo A. Malignant peripheric nerve sheath tumor of the orbit: first description of orbital location in a patient with NF1. Neurocirugia (Astur). 2010;21(1):37–45.

    CAS  Google Scholar 

  166. Verdijk RM, et al. TP53 mutation analysis of malignant peripheral nerve sheath tumors. J Neuropathol Exp Neurol. 2010;69(1):16–26.

    CAS  PubMed  Google Scholar 

  167. Overweg-Plandsoen WC, et al. Neurofibromatosis type 1: a survey of 195 patients. Ned Tijdschr Geneeskd. 1997;141(13):624–9.

    CAS  PubMed  Google Scholar 

  168. Poyhonen M, Niemela S, Herva R. Risk of malignancy and death in neurofibromatosis. Arch Pathol Lab Med. 1997;121(2):139–43.

    CAS  PubMed  Google Scholar 

  169. Rothenberg AB, et al. Neuroblastoma-remembering the three physicians who described it a century ago: James Homer Wright, William Pepper, and Robert Hutchison. Pediatr Radiol. 2009;39(2):155–60.

    PubMed  Google Scholar 

  170. Okamatsu C, et al. Clinicopathological characteristics of ganglioneuroma and ganglioneuroblastoma: a report from the CCG and COG. Pediatr Blood Cancer. 2009;53(4):563–9.

    PubMed Central  PubMed  Google Scholar 

  171. Romero R, et al. Peripheral primitive neuroectodermal tumour of the orbit. Br J Ophthalmol. 2011;95(7):915–20.

    PubMed  Google Scholar 

  172. Chokthaweesak W, et al. Primitive neuroectodermal tumor of the orbit in adults: a case series. Ophthal Plast Reconstr Surg. 2011;27(3):173–9.

    PubMed  Google Scholar 

  173. Luo W, Xiao EH. CT, MRI and pathologic features of peripheral primitive neuroectodermal tumors: a report of eight cases with literature review. Ai Zheng. 2008;27(6):627–32.

    PubMed  Google Scholar 

  174. Jedlicka P. Ewing Sarcoma, an enigmatic malignancy of likely progenitor cell origin, driven by transcription factor oncogenic fusions. Int J Clin Exp Pathol. 2010;3(4):338–47.

    CAS  PubMed Central  PubMed  Google Scholar 

  175. Fratkin JD, et al. Wilms’ tumor metastatic to the orbit. JAMA. 1977;238(17):1841–2.

    CAS  PubMed  Google Scholar 

  176. Kahwash SB, Qualman SJ. Cutaneous lymphoblastic lymphoma in children: report of six cases with precursor B-cell lineage. Pediatr Dev Pathol. 2002;5(1):45–53.

    PubMed  Google Scholar 

  177. Randolph TR. Advances in acute lymphoblastic leukemia. Clin Lab Sci. 2004;17(4):235–45.

    PubMed  Google Scholar 

  178. Gunduz K, Esmaeli B. Diagnosis and Management of Malignant Tumors of the Eyelid, Conjunctiva, and Orbit. Expert Rev Ophthalmol. 2008;3(1):63–75.

    Google Scholar 

  179. Hoyt WF, et al. Malignant optic glioma of adulthood. Brain. 1973;96(1):121–32.

    CAS  PubMed  Google Scholar 

  180. Tari AS, Fard MA. Solitary orbital paget disease: a case report. Orbit. 2010;29(4):219–21.

    PubMed  Google Scholar 

  181. Goldberg S, et al. Sarcomatous transformation of the orbit in a patient with Paget’s disease. Ophthalmology. 2000;107(8):1464–7.

    CAS  PubMed  Google Scholar 

  182. Harris AE, et al. Giant cell tumor of the skull: a case report and review of the literature. Surg Neurol. 2004;61(3):274–7.

    PubMed  Google Scholar 

  183. Goisis M, et al. Fibrous dysplasia of the orbital region: current clinical perspectives in ophthalmology and cranio-maxillofacial surgery. Ophthal Plast Reconstr Surg. 2006;22(5):383–7.

    PubMed  Google Scholar 

  184. Selva D, et al. Primary bone tumors of the orbit. Surv Ophthalmol. 2004;49(3):328–42.

    PubMed  Google Scholar 

  185. Chen CJ, et al. Malignant infantile osteopetrosis initially presenting with neonatal hypocalcemia: case report. Ann Hematol. 2003;82(1):64–7.

    PubMed  Google Scholar 

  186. Stark Z, Savarirayan R. Osteopetrosis. Orphanet J Rare Dis. 2009;4:5.

    PubMed Central  PubMed  Google Scholar 

  187. Kashkouli MB, et al. Primary endo-orbital osteoid osteoma. Orbit. 2008;27(3):211–3.

    PubMed  Google Scholar 

  188. Dhermy P, Mazabraud A, Offret G. Tumors and pseudo-tumoral dysplasias of orbital bones. Arch Ophtalmol Paris. 1977;37(4):249–72.

    CAS  PubMed  Google Scholar 

  189. Blodi FC. Pathology of orbital bones. The XXXII Edward Jackson Memorial lecture. Am J Ophthalmol. 1976;81(1):1–26.

    CAS  PubMed  Google Scholar 

  190. McHugh JB, Mukherji SK, Lucas DR. Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features. Arch Pathol Lab Med. 2009;133(10):1587–93.

    PubMed  Google Scholar 

  191. Morita R, Shimada K, Kawakami S. Low-grade central osteosarcoma of the orbit. J Craniofac Surg. 2012;23(3):e178–80.

    PubMed  Google Scholar 

  192. Fan JC, et al. Primary orbital extraskeletal osteosarcoma. Orbit. 2011;30(6):297–9.

    PubMed  Google Scholar 

  193. Khouja N, et al. Mesenchymal extraskeletal chondrosarcoma of the orbit. Report of a case and review of the literature. Surg Neurol. 1999;52(1):50–3.

    CAS  PubMed  Google Scholar 

  194. Daicker BC. Orbital chordoma. Ophthalmologica. 1978;176(4):236–9.

    CAS  PubMed  Google Scholar 

  195. Vidor I, et al. Chordoma of the anterior cranial fossa and ethmoids with orbital involvement. Orbit. 2008;27(6):444–50.

    PubMed  Google Scholar 

  196. Moshari A, et al. Ectopic chordoma with orbital invasion. Am J Ophthalmol. 2001;131(3):400–1.

    CAS  PubMed  Google Scholar 

  197. Louis DN, et al. WHO classification of tumours of the central nervous system. In: Bosman FT, editor. World Health Organization classification of tumours. 4th ed. Lyon: International Agency for Research on Cancer; 2007.

    Google Scholar 

  198. Walsh F. Meningiomas, primary within the orbit and optic canal. In: Neuro-ophthalmology, Symposium of the University of Miami and the Bascom Palmer Eye Institute. Halladale: Huffman Pub Co.; 1969.

    Google Scholar 

  199. Mawrin C, Perry A. Pathological classification and molecular genetics of meningiomas. J Neurooncol. 2010;99(3):379–91.

    CAS  PubMed  Google Scholar 

  200. Wiemels J, Wrensch M, Claus EB. Epidemiology and etiology of meningioma. J Neurooncol. 2010;99(3):307–14.

    PubMed Central  PubMed  Google Scholar 

  201. Jakobiec FA, McLean I, Font RL. Clinicopathologic characteristics of orbital lymphoid hyperplasia. Ophthalmology. 1979;86(5):948–66.

    CAS  PubMed  Google Scholar 

  202. Knowles DM. Malignant lymphomas and lymphoid hyperplasias that occur in the ocular adnexa (orbit, conjunctiva and eyelids). In: Knowles DM, editor. Neoplastic hematopathology. Philadelphia: Lippincott Williams & Wilkins; 2001. p. 1304.

    Google Scholar 

  203. McKelvie PA, et al. Ocular adnexal lymphoproliferative disease: a series of 73 cases. Clin Exp Ophthalmol. 2001;29(6):387–93.

    CAS  Google Scholar 

  204. Coupland SE, et al. Prognostic value of cell-cycle markers in ocular adnexal lymphoma: an assessment of 230 cases. Graefes Arch Clin Exp Ophthalmol. 2004;242(2):130–45.

    PubMed  Google Scholar 

  205. Stacy RC, et al. Unifocal and multifocal reactive lymphoid hyperplasia vs follicular lymphoma of the ocular adnexa. Am J Ophthalmol. 2010;150(3):412–26.e1.

    PubMed  Google Scholar 

  206. Dogan A, et al. CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas. Am J Surg Pathol. 2000;24(6):846–52.

    CAS  PubMed  Google Scholar 

  207. Andrew NH, Kearney D, Selva D. Intraorbital corticosteroid injection for orbital reactive lymphoid hyperplasia. Eye (Lond). 2013;27:561–3.

    CAS  Google Scholar 

  208. Ho HH, et al. Treatment of benign lymphoid hyperplasia of the orbit with rituximab. Ophthal Plast Reconstr Surg. 2010;26(1):11–3.

    PubMed  Google Scholar 

  209. Johansen S, et al. Orbital space-occupying lesions in Denmark 1974–1997. Acta Ophthalmol Scand. 2000;78(5):547–52.

    CAS  PubMed  Google Scholar 

  210. Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: The 2002 Montgomery lecture, part 1. Ophthalmology. 2004;111(5):997–1008.

    PubMed  Google Scholar 

  211. Ferry JA, et al. Lymphoma of the ocular adnexa: a study of 353 cases. Am J Surg Pathol. 2007;31(2):170–84.

    PubMed  Google Scholar 

  212. Sjo LD, et al. Increasing incidence of ophthalmic lymphoma in Denmark from 1980 to 2005. Invest Ophthalmol Vis Sci. 2008;49(8):3283–8.

    PubMed  Google Scholar 

  213. Henderson JW, Banks PM, Yeatts RP. T-cell lymphoma of the orbit. Mayo Clin Proc. 1989;64(8):940–4.

    CAS  PubMed  Google Scholar 

  214. Chan CC, et al. Detection of Helicobacter pylori and Chlamydia pneumoniae genes in primary orbital lymphoma. Trans Am Ophthalmol Soc. 2006;104:62–70.

    PubMed Central  PubMed  Google Scholar 

  215. Jakobiec FA. Ocular adnexal lymphoid tumors: progress in need of clarification. Am J Ophthalmol. 2008;145(6):941–50.

    PubMed  Google Scholar 

  216. Sjo LD, et al. Primary lymphoma of the lacrimal sac: an EORTC ophthalmic oncology task force study. Br J Ophthalmol. 2006;90(8):1004–9.

    CAS  PubMed Central  PubMed  Google Scholar 

  217. Coupland SE, Damato B. Lymphomas involving the eye and the ocular adnexa. Curr Opin Ophthalmol. 2006;17(6):523–31.

    PubMed  Google Scholar 

  218. Sjo LD, et al. Extranodal marginal zone lymphoma in the ocular region: clinical, immunophenotypical, and cytogenetical characteristics. Invest Ophthalmol Vis Sci. 2009;50(2):516–22.

    PubMed  Google Scholar 

  219. Coupland SE, Hummel M, Stein H. Ocular adnexal lymphomas: five case presentations and a review of the literature. Surv Ophthalmol. 2002;47(5):470–90.

    PubMed  Google Scholar 

  220. Coupland SE, et al. A TNM-based clinical staging system of ocular adnexal lymphomas. Arch Pathol Lab Med. 2009;133(8):1262–7.

    PubMed  Google Scholar 

  221. Uno T, et al. Radiotherapy for extranodal, marginal zone, B-cell lymphoma of mucosa-associated lymphoid tissue originating in the ocular adnexa: a multiinstitutional, retrospective review of 50 patients. Cancer. 2003;98(4):865–71.

    PubMed  Google Scholar 

  222. Faridpooya K, et al. Precursor B lymphoblastic lymphoma of the orbit in a child: an unusual presentation of a non-Hodgkin lymphoma. Orbit. 2006;25(2):153–7.

    CAS  PubMed  Google Scholar 

  223. Sahjpaul R, Elisevich K, Allen L. Hodgkin’s disease of the orbit with intracranial extension. Ophthalmic Surg Lasers. 1996;27(3):239–42.

    CAS  PubMed  Google Scholar 

  224. Rodman HI, Font RL. Orbital involvement in multiple myeloma. Review of the literature and report of three cases. Arch Ophthalmol. 1972;87(1):30–5.

    CAS  PubMed  Google Scholar 

  225. Howling SJ, et al. Case report: the CT features of orbital multiple myeloma. Clin Radiol. 1998;53(4):304–5.

    CAS  PubMed  Google Scholar 

  226. Ranchod TM, et al. Waldenstrom macroglobulinemia of the orbit. Ophthal Plast Reconstr Surg. 2008;24(1):76–7.

    PubMed  Google Scholar 

  227. Ohta K, et al. Primary granulocytic sarcoma in the sphenoidal bone and orbit. Childs Nerv Syst. 2003;19(9):674–9.

    PubMed  Google Scholar 

  228. Russo V, et al. Orbital and ocular manifestations of acute childhood leukemia: clinical and statistical analysis of 180 patients. Eur J Ophthalmol. 2008;18(4):619–23.

    CAS  PubMed  Google Scholar 

  229. Mangla D, Dewan M, Meyer DR. Adult orbital myeloid sarcoma (granulocytic sarcoma): two cases and review of the literature. Orbit. 2012;31(6):438–40.

    PubMed  Google Scholar 

  230. Herwig MC, et al. Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature. Surv Ophthalmol. 2013;58(4):330–40.

    PubMed Central  PubMed  Google Scholar 

  231. Haroche J, Arnaud L, Amoura Z. Erdheim-Chester disease. Curr Opin Rheumatol. 2012;24(1):53–9.

    PubMed  Google Scholar 

  232. Haroche J, et al. Dramatic efficacy of vemurafenib in both multisystemic and refractory Erdheim-Chester disease and Langerhans cell histiocytosis harboring the BRAF V600E mutation. Blood. 2013;121(9):1495–500.

    CAS  PubMed  Google Scholar 

  233. Vemuganti GK, Naik MN, Honavar SG. Rosai dorfman disease of the orbit. J Hematol Oncol. 2008;1:7.

    PubMed Central  PubMed  Google Scholar 

  234. Alyahya GA, Prause JU, Heegaard S. Castleman’s disease in the orbit. A 20-year follow-up. Acta Ophthalmol Scand. 2002;80(5):540–2.

    PubMed  Google Scholar 

  235. Venizelos I, et al. Orbital involvement in Castleman disease. Surv Ophthalmol. 2010;55(3):247–55.

    PubMed  Google Scholar 

  236. Ratnatunga N, et al. Primary biphasic synovial sarcoma of the orbit. J Clin Pathol. 1992;45(3):265–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  237. Votruba M, et al. Primary monophasic synovial sarcoma of the conjunctiva. Br J Ophthalmol. 2002;86(12):1453–4.

    CAS  PubMed Central  PubMed  Google Scholar 

  238. Liu K, et al. Primary synovial sarcoma in the orbit. J AAPOS. 2012;16(6):582–4.

    CAS  PubMed  Google Scholar 

  239. Wladis EJ, Farber MG, Nepo AG. Metastatic synovial sarcoma to the orbit. Ophthal Plast Reconstr Surg. 2012;28(6):e131–2.

    PubMed  Google Scholar 

  240. Gunduz K, et al. Malignant rhabdoid tumor of the orbit. Arch Ophthalmol. 1998;116(2):243–6.

    CAS  PubMed  Google Scholar 

  241. Kook KH, et al. A case of congenital orbital malignant rhabdoid tumor: systemic metastasis following exenteration. Ophthalmologica. 2009;223(4):274–8.

    PubMed Central  PubMed  Google Scholar 

  242. Gunduz K, et al. Periorbital cellular blue nevus leading to orbitopalpebral and intracranial melanoma. Ophthalmology. 1998;105(11):2046–50.

    CAS  PubMed  Google Scholar 

  243. Nakanishi K, et al. Recurrent melanotic neuroectodermal tumor in the orbit successfully treated with resection followed by pediculated periosteal flaps. Pediatr Blood Cancer. 2008;51(3):430–2.

    PubMed  Google Scholar 

  244. Kapadia SB, et al. Melanotic neuroectodermal tumor of infancy. Clinicopathological, immunohistochemical, and flow cytometric study. Am J Surg Pathol. 1993;17(6):566–73.

    CAS  PubMed  Google Scholar 

  245. Makhdoomi R, et al. Orbital paraganglioma – a case report and review of the literature. Clin Neuropathol. 2010;29(2):100–4.

    CAS  PubMed  Google Scholar 

  246. Mititelu M, Stanton CA, Yeatts RP. Primary neuroendocrine tumor of the orbit progressing to neoplastic meningitis. Ophthal Plast Reconstr Surg. 2008;24(3):231–3.

    PubMed  Google Scholar 

  247. Rose AM, Kabiru J, Rose GE. Alveolar soft-part sarcoma of the orbit. Afr J Paediatr Surg. 2011;8(1):82–4.

    PubMed  Google Scholar 

  248. Joyama S, et al. Chromosome rearrangement at 17q25 and xp11.2 in alveolar soft-part sarcoma: a case report and review of the literature. Cancer. 1999;86(7):1246–50.

    CAS  PubMed  Google Scholar 

  249. Daigeler A, et al. Alveolar soft part sarcoma: clinicopathological findings in a series of 11 cases. World J Surg Oncol. 2008;6:71.

    PubMed Central  PubMed  Google Scholar 

  250. Gunalp I, Gunduz K. Secondary orbital tumors. Ophthal Plast Reconstr Surg. 1997;13(1):31–5.

    CAS  PubMed  Google Scholar 

  251. Krishna M. Diagnosis of metastatic neoplasms: an immunohistochemical approach. Arch Pathol Lab Med. 2010;134(2):207–15.

    PubMed  Google Scholar 

  252. von Holstein SL, et al. Lacrimal gland lesions in Denmark between 1974 and 2007. Acta Ophthalmol. 2013;91(4):349–54.

    Google Scholar 

  253. de la Cuadra-Blanco C, Peces-Pena MD, Merida-Velasco JR. Morphogenesis of the human lacrimal gland. J Anat. 2003;203(5):531–6.

    PubMed Central  PubMed  Google Scholar 

  254. Makarenkova HP, et al. FGF10 is an inducer and Pax6 a competence factor for lacrimal gland development. Development. 2000;127(12):2563–72.

    CAS  PubMed  Google Scholar 

  255. Kural G, Serifoglu A, Erture S. A case of aberrant lacrimal gland and fistula. Br J Ophthalmol. 1989;73(5):376–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  256. O’Connor MA, Archer DB, Hart PM. Congenital fistulae of the lacrimal gland. Br J Ophthalmol. 1985;69(9):711–3.

    PubMed Central  PubMed  Google Scholar 

  257. Wieczorek R, et al. The immunoarchitecture of the normal human lacrimal gland. Relevancy for understanding pathologic conditions. Ophthalmology. 1988;95(1):100–9.

    CAS  PubMed  Google Scholar 

  258. Knop E, Knop N. Lacrimal drainage-associated lymphoid tissue (LDALT): a part of the human mucosal immune system. Invest Ophthalmol Vis Sci. 2001;42(3):566–74.

    CAS  PubMed  Google Scholar 

  259. Rai P, Shah SA, Kirshan H. Acute Dacryadenitis-analysis of 23 cases. Med Channel. 2009;15:71–6.

    Google Scholar 

  260. Srivastava V. Acute suppurative dacryoadenitis. Med J Armed Forces India. 2000;56:151–2.

    Google Scholar 

  261. Shields CL, et al. Clinicopathologic review of 142 cases of lacrimal gland lesions. Ophthalmology. 1989;96(4):431–5.

    CAS  PubMed  Google Scholar 

  262. Hurwitz JJ. A practical approach to the management of lacrimal gland lesions. Ophthalmic Surg. 1982;13(10):829–36.

    CAS  PubMed  Google Scholar 

  263. Al-Hashimi I, et al. Frequency and predictive value of the clinical manifestations in Sjogren’s syndrome. J Oral Pathol Med. 2001;30(1):1–6.

    CAS  PubMed  Google Scholar 

  264. Jakobiec FA, Stacy RC, Hatton MP. Clinical characterization and immunopathologic features of sclerosing dacryoadenitis and riedel thyroiditis. Arch Ophthalmol. 2010;128(12):1626–8.

    PubMed  Google Scholar 

  265. Burkhalter E. Unique presentation of systemic lupus erythematosus. Arthritis Rheum. 1973;16(3):428.

    CAS  PubMed  Google Scholar 

  266. Pulido JS, et al. Ocular manifestations of patients with circulating antineutrophil cytoplasmic antibodies. Arch Ophthalmol. 1990;108(6):845–50.

    CAS  PubMed  Google Scholar 

  267. Nahata MC, Sethi PK. Traumatic prolapse of the lacrimal gland. Indian J Ophthalmol. 1973;21(1):43–4.

    CAS  PubMed  Google Scholar 

  268. Halborg J, et al. Stones in the lacrimal gland: a rare condition. Acta Ophthalmol. 2009;87(6):672–5.

    PubMed  Google Scholar 

  269. Prabhakaran VC, et al. Amyloidosis of lacrimal gland. Indian J Ophthalmol. 2009;57(6):461–3.

    PubMed Central  PubMed  Google Scholar 

  270. Damato BE, et al. Senile atrophy of the human lacrimal gland: the contribution of chronic inflammatory disease. Br J Ophthalmol. 1984;68(9):674–80.

    CAS  PubMed Central  PubMed  Google Scholar 

  271. Shields JA, et al. Classification and incidence of space-occupying lesions of the orbit. A survey of 645 biopsies. Arch Ophthalmol. 1984;102(11):1606–11.

    CAS  PubMed  Google Scholar 

  272. Kennedy RE. An evaluation of 820 orbital cases. Trans Am Ophthalmol Soc. 1984;82:134–57.

    CAS  PubMed Central  PubMed  Google Scholar 

  273. Ni C, Kuo PK, Dryja TP. Histopathological classification of 272 primary epithelial tumors of the lacrimal gland. Chin Med J (Engl). 1992;105(6):481–5.

    CAS  Google Scholar 

  274. Shields JA, et al. Review: primary epithelial malignancies of the lacrimal gland: the 2003 Ramon L. Font lecture. Ophthal Plast Reconstr Surg. 2004;20(1):10–21.

    PubMed  Google Scholar 

  275. Barnes L, et al. Pathology and genetics of head and neck tumours. 3rd ed. World Health Organization Classification of Tumours, vol 9. Lyon: IARC Press; 2005.

    Google Scholar 

  276. Weis E, et al. Epithelial lacrimal gland tumors: pathologic classification and current understanding. Arch Ophthalmol. 2009;127(8):1016–28.

    PubMed  Google Scholar 

  277. von Holstein SL, et al. Granular cell tumour of the lacrimal gland. Acta Ophthalmol. 2009;87(8):926–7.

    Google Scholar 

  278. Snaathorst J, et al. Primary epithelial tumors of the lacrimal gland; a retrospective analysis of 22 patients. Int J Oral Maxillofac Surg. 2009;38(7):751–7.

    CAS  PubMed  Google Scholar 

  279. Prabhakaran VC, et al. Lesions mimicking lacrimal gland pleomorphic adenoma. Br J Ophthalmol. 2010;94(11):1509–12.

    PubMed  Google Scholar 

  280. Gupta A, Khandelwal A. Lacrimal gland pleomorphic adenoma: an inconceivable diagnosis in a child. BMJ Case Rep. 2013;2013:bcr009138.

    Google Scholar 

  281. Vagefi MR, et al. Atypical presentations of pleomorphic adenoma of the lacrimal gland. Ophthal Plast Reconstr Surg. 2007;23(4):272–4.

    PubMed  Google Scholar 

  282. Rose GE, Wright JE. Pleomorphic adenoma of the lacrimal gland. Br J Ophthalmol. 1992;76(7):395–400.

    CAS  PubMed Central  PubMed  Google Scholar 

  283. Vangveeravong S, et al. Tumors arising in the palpebral lobe of the lacrimal gland. Ophthalmology. 1996;103(10):1606–12.

    CAS  PubMed  Google Scholar 

  284. Ramlee N, Ramli N, Tajudin LS. Pleomorphic adenoma in the palpebral lobe of the lacrimal gland misdiagnosed as chalazion. Orbit. 2007;26(2):137–9.

    PubMed  Google Scholar 

  285. Sen S, et al. Pleomorphic adenomas of the lacrimal gland: a clinicopathological analysis. Clin Exp Ophthalmol. 2004;32(5):523–5.

    Google Scholar 

  286. McNab AA, Satchi K. Recurrent lacrimal gland pleomorphic adenoma: clinical and computed tomography features. Ophthalmology. 2011;118(10):2088–92.

    PubMed  Google Scholar 

  287. Tong JT, et al. Benign mixed tumor arising from an accessory lacrimal gland of Wolfring. Ophthal Plast Reconstr Surg. 1995;11(2):136–8.

    CAS  PubMed  Google Scholar 

  288. Saini JS, Mukherjee AK, Naik P. Pleomorphic adenoma of Krause’s gland in lower lid. Indian J Ophthalmol. 1985;33(3):181–2.

    CAS  PubMed  Google Scholar 

  289. Venkataramayya K. Pleomorphic adenoma of Krause’s gland. Indian J Ophthalmol. 1976;23(4):38–9.

    CAS  PubMed  Google Scholar 

  290. Grossniklaus HE, Abbuhl MF, McLean IW. Immunohistologic properties of benign and malignant mixed tumor of the lacrimal gland. Am J Ophthalmol. 1990;110(5):540–9.

    CAS  PubMed  Google Scholar 

  291. Zhao M, et al. Immunohistochemical demonstration of bone morphogenetic protein-2 and type II collagen in pleomorphic adenoma of salivary glands. J Oral Pathol Med. 1998;27(7):293–6.

    CAS  PubMed  Google Scholar 

  292. Dardick I. Mounting evidence against current histogenetic concepts for salivary gland tumorigenesis. Eur J Morphol. 1998;36(Suppl):257–61.

    PubMed  Google Scholar 

  293. Margaritescu C, et al. Tumoral stroma of salivary pleomorphic adenoma – histopathological, histochemical and immunohistochemical study. Rom J Morphol Embryol. 2005;46(3):211–23.

    PubMed  Google Scholar 

  294. Bullerdiek J, et al. Cytogenetic subtyping of 220 salivary gland pleomorphic adenomas: correlation to occurrence, histological subtype, and in vitro cellular behavior. Cancer Genet Cytogenet. 1993;65(1):27–31.

    CAS  PubMed  Google Scholar 

  295. Alyahya GA, et al. Pleomorphic adenoma arising in an accessory lacrimal gland of Wolfring. Ophthalmology. 2006;113(5):879–82.

    PubMed  Google Scholar 

  296. Maran AG, Mackenzie IJ, Stanley RE. Recurrent pleomorphic adenomas of the parotid gland. Arch Otolaryngol. 1984;110(3):167–71.

    CAS  PubMed  Google Scholar 

  297. Font FR, Gamel JW. Epithelial tumors of the lacrimal gland: analysis of 265 cases. In: Jakobiec FA, editor. Ocular and adnexal tumors. Birmingham: Aesculapius; 1978. p. 787–805.

    Google Scholar 

  298. Chandrasekhar J, Farr DR, Whear NM. Pleomorphic adenoma of the lacrimal gland: case report. Br J Oral Maxillofac Surg. 2001;39(5):390–3.

    CAS  PubMed  Google Scholar 

  299. Bonavolonta G, et al. Warthin tumor of the lacrimal gland. Am J Ophthalmol. 1997;124(6):857–8.

    CAS  PubMed  Google Scholar 

  300. Thompson AS, Bryant Jr HC. Histogenesis of papillary cystadenoma lymphomatosum (Warthin’s tumor) of the parotid salivary gland. Am J Pathol. 1950;26(5):807–49.

    CAS  PubMed Central  PubMed  Google Scholar 

  301. Kleinsasser O, Klein HJ. Basal cell adenoma of the salivary glands. Arch Klin Exp Ohren Nasen Kehlkopfheilkd. 1967;189(3):302–16.

    CAS  PubMed  Google Scholar 

  302. Zarbo RJ, et al. Salivary gland basal cell and canalicular adenomas: immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations. Arch Pathol Lab Med. 2000;124(3):401–5.

    CAS  PubMed  Google Scholar 

  303. Silbert JE, Braich P, Misra RP. Basal cell cystadenoma of the lacrimal gland: diagnostic pitfalls of a basaloid pattern in lacrimal tumours. Int Ophthalmol. 2011;31(1):43–6.

    PubMed  Google Scholar 

  304. Khalil M, Arthurs B. Basal cell adenocarcinoma of the lacrimal gland. Ophthalmology. 2000;107(1):164–8.

    CAS  PubMed  Google Scholar 

  305. Hartman LJ, Mourits MP, Canninga-van Dijk MR. An unusual tumour of the lacrimal gland. Br J Ophthalmol. 2003;87(3):363.

    CAS  PubMed Central  PubMed  Google Scholar 

  306. Economou MA, Seregard S, Sahlin S. Oncocytoma of the lacrimal gland. Acta Ophthalmol Scand. 2007;85(5):576–7.

    PubMed  Google Scholar 

  307. Ostergaard J, Prause JU, Heegaard S. Oncocytic lesions of the ophthalmic region: a clinicopathological study with emphasis on cytokeratin expression. Acta Ophthalmol. 2011;89(3):263–7.

    PubMed  Google Scholar 

  308. Riedel K, Stefani FH, Kampik A. Oncocytoma of the ocular adnexa. Klin Monbl Augenheilkd. 1983;182(6):544–8.

    CAS  PubMed  Google Scholar 

  309. Tandler B. Fine structure of oncocytes in human salivary glands. Virchows Arch Pathol Anat Physiol Klin Med. 1966;341(4):317–26.

    CAS  PubMed  Google Scholar 

  310. Prasad AR, et al. The myoepithelial immunophenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. Arch Pathol Lab Med. 1999;123(9):801–6.

    CAS  PubMed  Google Scholar 

  311. Calle CA, et al. Oncocytoma of the lacrimal gland: case report and review of the literature. Orbit. 2006;25(3):243–7.

    PubMed  Google Scholar 

  312. Hamperl H. Benign and malignant oncocytoma. Cancer. 1962;15:1019–27.

    CAS  PubMed  Google Scholar 

  313. Porcelli AM, et al. The genetic and metabolic signature of oncocytic transformation implicates HIF1alpha destabilization. Hum Mol Genet. 2010;19(6):1019–32.

    CAS  PubMed  Google Scholar 

  314. Font RL, Garner A. Myoepithelioma of the lacrimal gland: report of a case with spindle cell morphology. Br J Ophthalmol. 1992;76(10):634–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  315. Grossniklaus HE, et al. Myoepithelioma of the lacrimal gland. Arch Ophthalmol. 1997;115(12):1588–90.

    CAS  PubMed  Google Scholar 

  316. Bolzoni A, et al. Benign myoepithelioma of the lacrimal gland: report of a case. Eur Arch Otorhinolaryngol. 2005;262(3):186–8.

    PubMed  Google Scholar 

  317. Sassano P, et al. Interleukine-6 (IL-6) may be a link between myasthenia gravis and myoepithelioma of the parotid gland. Med Hypotheses. 2007;68(2):314–7.

    CAS  PubMed  Google Scholar 

  318. Jaeger RG, et al. Expression of smooth-muscle actin in cultured cells from human plasmacytoid myoepithelioma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997;84(6):663–7.

    CAS  PubMed  Google Scholar 

  319. el-Naggar AK, et al. Cytogenetic analysis of a primary salivary gland myoepithelioma. Cancer Genet Cytogenet. 1999;113(1):49–53.

    CAS  PubMed  Google Scholar 

  320. Okudela K, et al. Myoepithelioma of the lacrimal gland: report of a case with potentially malignant transformation. Pathol Int. 2000;50(3):238–43.

    CAS  PubMed  Google Scholar 

  321. Font RL, Smith SL, Bryan RG. Malignant epithelial tumors of the lacrimal gland: a clinicopathologic study of 21 cases. Arch Ophthalmol. 1998;116(5):613–6.

    CAS  PubMed  Google Scholar 

  322. Ferry AP, Font RL. Carcinoma metastatic to the orbit. Mod Probl Ophthalmol. 1975;14:377–81.

    CAS  PubMed  Google Scholar 

  323. Stell PM. Adenoid cystic carcinoma. Clin Otolaryngol Allied Sci. 1986;11(4):267–91.

    CAS  PubMed  Google Scholar 

  324. Paulino AF, Huvos AG. Epithelial tumors of the lacrimal glands: a clinicopathologic study. Ann Diagn Pathol. 1999;3(4):199–204.

    CAS  PubMed  Google Scholar 

  325. Henderson JW. Intrinsic neoplasms of the lacrimal gland. In: Henderson JW, editor. Orbital tumors. Philadelphia: W.B. Saunders; 1973. p. 409–43.

    Google Scholar 

  326. Font RL, Croxatto JO, Rao NA. Tumors of the lacrimal gland. In: Tumors of the eye and ocular adnexa. Washington, DC: American Registry of Pathology/Armed Forces Institute of Pathology; 2006. p. 223–346.

    Google Scholar 

  327. Zhou Q, et al. Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis. Diagn Pathol. 2012;7:119.

    PubMed Central  PubMed  Google Scholar 

  328. Seethala RR, et al. Adenoid cystic carcinoma with high-grade transformation: a report of 11 cases and a review of the literature. Am J Surg Pathol. 2007;31(11):1683–94.

    PubMed  Google Scholar 

  329. Szanto PA, et al. Histologic grading of adenoid cystic carcinoma of the salivary glands. Cancer. 1984;54(6):1062–9.

    CAS  PubMed  Google Scholar 

  330. Chau Y, et al. Dedifferentiation of adenoid cystic carcinoma: report of a case implicating p53 gene mutation. Hum Pathol. 2001;32(12):1403–7.

    CAS  PubMed  Google Scholar 

  331. Esmaeli B, et al. Surgical management of locally advanced adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg. 2006;22(5):366–70.

    PubMed  Google Scholar 

  332. Woo VL, Bhuiya T, Kelsch R. Assessment of CD43 expression in adenoid cystic carcinomas, polymorphous low-grade adenocarcinomas, and monomorphic adenomas. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;102(4):495–500.

    PubMed  Google Scholar 

  333. von Holstein SL, et al. Adenoid cystic carcinoma of the lacrimal gland: MYB gene activation, genomic imbalances, and clinical characteristics. Ophthalmology. 2013;120:2130–8.

    Google Scholar 

  334. Mitani Y, et al. Comprehensive analysis of the MYB-NFIB gene fusion in salivary adenoid cystic carcinoma: incidence, variability, and clinicopathologic significance. Clin Cancer Res. 2010;16(19):4722–31.

    CAS  PubMed  Google Scholar 

  335. Seethala RR. Histologic grading and prognostic biomarkers in salivary gland carcinomas. Adv Anat Pathol. 2011;18(1):29–45.

    PubMed  Google Scholar 

  336. Le Tourneau C, et al. Role of chemotherapy and molecularly targeted agents in the treatment of adenoid cystic carcinoma of the lacrimal gland. Br J Ophthalmol. 2011;95(11):1483–9.

    PubMed  Google Scholar 

  337. Jaso J, Malhotra R. Adenoid cystic carcinoma. Arch Pathol Lab Med. 2011;135(4):511–5.

    PubMed  Google Scholar 

  338. Zhang J, Peng B. In vitro angiogenesis and expression of nuclear factor kappaB and VEGF in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma. BMC Cancer. 2007;7:95.

    CAS  PubMed Central  PubMed  Google Scholar 

  339. Preisegger KH, et al. Prognostic impact of molecular analyses in adenoid cystic carcinomas of the salivary gland. Onkologie. 2001;24(3):273–7.

    CAS  PubMed  Google Scholar 

  340. Gamel JW, Font RL. Adenoid cystic carcinoma of the lacrimal gland: the clinical significance of a basaloid histologic pattern. Hum Pathol. 1982;13(3):219–25.

    CAS  PubMed  Google Scholar 

  341. Rao PH, et al. Deletion of 1p32-p36 is the most frequent genetic change and poor prognostic marker in adenoid cystic carcinoma of the salivary glands. Clin Cancer Res. 2008;14(16):5181–7.

    CAS  PubMed  Google Scholar 

  342. Luna MA, et al. Flow cytometric DNA content of adenoid cystic carcinoma of submandibular gland. Correlation of histologic features and prognosis. Arch Otolaryngol Head Neck Surg. 1990;116(11):1291–6.

    CAS  PubMed  Google Scholar 

  343. Lee DA, et al. A clinicopathologic study of primary adenoid cystic carcinoma of the lacrimal gland. Ophthalmology. 1985;92(1):128–34.

    CAS  PubMed  Google Scholar 

  344. Esmaeli B, et al. Outcomes in patients with adenoid cystic carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg. 2004;20(1):22–6.

    PubMed  Google Scholar 

  345. Lin YC, et al. Clinicopathological features of salivary and non-salivary adenoid cystic carcinomas. Int J Oral Maxillofac Surg. 2012;41(3):354–60.

    PubMed  Google Scholar 

  346. Bernardini FP, Devoto MH, Croxatto JO. Epithelial tumors of the lacrimal gland: an update. Curr Opin Ophthalmol. 2008;19(5):409–13.

    PubMed  Google Scholar 

  347. Hu YH, et al. Aberrant protein expression and promoter methylation of p16 gene are correlated with malignant transformation of salivary pleomorphic adenoma. Arch Pathol Lab Med. 2011;135(7):882–9.

    CAS  PubMed  Google Scholar 

  348. Currie ZI, Rose GE. Long-term risk of recurrence after intact excision of pleomorphic adenomas of the lacrimal gland. Arch Ophthalmol. 2007;125(12):1643–6.

    PubMed  Google Scholar 

  349. Ahn JY, et al. Pleomorphic adenocarcinoma of the lacrimal gland with multiple intracranial and spinal metastases. World J Surg Oncol. 2007;5:29.

    PubMed Central  PubMed  Google Scholar 

  350. Yamasaki T, et al. Multiple intracranial metastases following malignant evolution in recurrent pleomorphic adenoma of the lacrimal gland – case report. Neurol Med Chir (Tokyo). 1990;30(13):1038–42.

    CAS  Google Scholar 

  351. Chang CJ, et al. Carcinoma ex pleomorphic adenoma of the lacrimal gland: a case report. Ann Ophthalmol (Skokie). 2006;38(2):141–4.

    Google Scholar 

  352. Olsen KD, Lewis JE. Carcinoma ex pleomorphic adenoma: a clinicopathologic review. Head Neck. 2001;23(9):705–12.

    CAS  PubMed  Google Scholar 

  353. Galatoire O, et al. Adenocarcinoma in a pleomorphic adenoma of the lacrimal gland: a case study. J Fr Ophtalmol. 2005;28(8):896–901.

    CAS  PubMed  Google Scholar 

  354. Takahira M, et al. Cystic carcinoma ex pleomorphic adenoma of the lacrimal gland. Ophthal Plast Reconstr Surg. 2007;23(5):407–9.

    PubMed  Google Scholar 

  355. Perzin KH, et al. Lacrimal gland malignant mixed tumors (carcinomas arising in benign mixed tumors): a clinico-pathologic study. Cancer. 1980;45(10):2593–606.

    CAS  PubMed  Google Scholar 

  356. Ishida M, et al. Case of ductal adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Rinsho Byori. 2009;57(8):746–51.

    PubMed  Google Scholar 

  357. Harada H. Histomorphological investigation regarding to malignant transformation of pleomorphic adenoma (so-called malignant mixed tumor) of the salivary gland origin: special reference to carcinosarcoma. Kurume Med J. 2000;47(4):307–23.

    CAS  PubMed  Google Scholar 

  358. Takahira M, et al. Carcinosarcoma of the lacrimal gland arising from a pleomorphic adenoma. Am J Ophthalmol. 2005;140(2):337–40.

    PubMed  Google Scholar 

  359. Mensink HW, Mooy C, Paridaens D. In situ adenocarcinoma ex pleomorphic adenoma of the lacrimal gland. Clin Exp Ophthalmol. 2005;33(6):669–71.

    Google Scholar 

  360. Tortoledo ME, Luna MA, Batsakis JG. Carcinomas ex pleomorphic adenoma and malignant mixed tumors. Histomorphologic indexes. Arch Otolaryngol. 1984;110(3):172–6.

    CAS  PubMed  Google Scholar 

  361. Cheuk W, Chan JK. Advances in salivary gland pathology. Histopathology. 2007;51(1):1–20.

    CAS  PubMed  Google Scholar 

  362. Ohtake S, et al. Precancerous foci in pleomorphic adenoma of the salivary gland: recognition of focal carcinoma and atypical tumor cells by P53 immunohistochemistry. J Oral Pathol Med. 2002;31(10):590–7.

    PubMed  Google Scholar 

  363. Rosa JC, et al. Immunohistochemical study of c-erbB-2 expression in carcinoma ex-pleomorphic adenoma. Histopathology. 1996;28(3):247–52.

    CAS  PubMed  Google Scholar 

  364. El-Naggar AK, et al. Molecular genetic alterations in carcinoma ex-pleomorphic adenoma: a putative progression model? Gene Chromosome Cancer. 2000;27(2):162–8.

    CAS  Google Scholar 

  365. Baek SO, et al. Primary adenocarcinoma of the lacrimal gland. Arch Plast Surg. 2012;39(5):578–80.

    PubMed Central  PubMed  Google Scholar 

  366. Clauser L, et al. Adenocarcinoma of the lacrimal gland: report of a case. J Oral Maxillofac Surg. 2002;60(3):318–21.

    PubMed  Google Scholar 

  367. Sofinski SJ, et al. Mucoepidermoid carcinoma of the lacrimal gland. Case report and review of the literature. Ophthal Plast Reconstr Surg. 1986;2(3):147–51.

    CAS  PubMed  Google Scholar 

  368. Eviatar JA, Hornblass A. Mucoepidermoid carcinoma of the lacrimal gland: 25 cases and a review and update of the literature. Ophthal Plast Reconstr Surg. 1993;9(3):170–81.

    CAS  PubMed  Google Scholar 

  369. Isayeva T, et al. Salivary mucoepidermoid carcinoma: demonstration of transcriptionally active human papillomavirus 16/18. Head Neck Pathol. 2013;7(2):135–48.

    PubMed Central  PubMed  Google Scholar 

  370. Dithmar S, et al. Mucoepidermoid carcinoma of an accessory lacrimal gland with orbital invasion. Ophthal Plast Reconstr Surg. 2000;16(2):162–6.

    CAS  PubMed  Google Scholar 

  371. Pulitzer DR, Eckert ER. Mucoepidermoid carcinoma of the lacrimal gland. An oxyphilic variant. Arch Ophthalmol. 1987;105(10):1406–9.

    CAS  PubMed  Google Scholar 

  372. Levin LA, et al. Mucoepidermoid carcinoma of the lacrimal gland. Report of a case with oncocytic features arising in a patient with chronic dacryops. Ophthalmology. 1991;98(10):1551–5.

    CAS  PubMed  Google Scholar 

  373. Brandwein MS, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. Am J Surg Pathol. 2001;25(7):835–45.

    CAS  PubMed  Google Scholar 

  374. Von Holstein SL, et al. CRTC1-MAML2 gene fusion in mucoepidermoid carcinoma of the lacrimal gland. Oncol Rep. 2012;27(5):1413–6.

    Google Scholar 

  375. Behboudi A, et al. Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. Gene Chromosome Cancer. 2006;45(5):470–81.

    CAS  Google Scholar 

  376. Yoo J, Robinson RA. H-ras gene mutations in salivary gland mucoepidermoid carcinomas. Cancer. 2000;88(3):518–23.

    CAS  PubMed  Google Scholar 

  377. Handra-Luca A, et al. MUC1, MUC2, MUC4, and MUC5AC expression in salivary gland mucoepidermoid carcinoma: diagnostic and prognostic implications. Am J Surg Pathol. 2005;29(7):881–9.

    PubMed  Google Scholar 

  378. Katz SE, et al. Primary ductal adenocarcinoma of the lacrimal gland. Ophthalmology. 1996;103(1):157–62.

    CAS  PubMed  Google Scholar 

  379. Kubota T, Moritani S, Ichihara S. Clinicopathologic and immunohistochemical features of primary ductal adenocarcinoma of lacrimal gland: five new cases and review of literature. Graefes Arch Clin Exp Ophthalmol. 2013;251(8):2071–6.

    PubMed  Google Scholar 

  380. Di Palma S, et al. Salivary duct carcinomas can be classified into luminal androgen receptor-positive, HER2 and basal-like phenotypes*. Histopathology. 2012;61(4):629–43.

    PubMed  Google Scholar 

  381. Wright JE, Rose GE, Garner A. Primary malignant neoplasms of the lacrimal gland. Br J Ophthalmol. 1992;76(7):401–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  382. Fenton S, et al. Primary squamous cell carcinoma of the lacrimal gland. Eye (Lond). 2003;17(3):424–5.

    CAS  Google Scholar 

  383. Su GW, Patipa M, Font RL. Primary squamous cell carcinoma arising from an epithelium-lined cyst of the lacrimal gland. Ophthal Plast Reconstr Surg. 2005;21(5):383–5.

    PubMed  Google Scholar 

  384. Hotta K, et al. Primary squamous cell carcinoma of the lacrimal gland. Clin Exp Ophthalmol. 2005;33(5):534–6.

    Google Scholar 

  385. Briscoe D, et al. Primary sebaceous carcinoma of the lacrimal gland. Br J Ophthalmol. 2001;85(5):625–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  386. Mooy CM. Intraepithelial sebaceous neoplasia invading the lacrimal gland. Br J Ophthalmol. 1997;81(7):612–3.

    CAS  PubMed  Google Scholar 

  387. Konrad EA, Thiel HJ. Adenocarcinoma of the lacrimal gland with sebaceous differentiation. A clinical study using light and electron microscopy. Graefes Arch Clin Exp Ophthalmol. 1983;221(2):81–5.

    CAS  PubMed  Google Scholar 

  388. Chan JK, et al. Specific association of Epstein-Barr virus with lymphoepithelial carcinoma among tumors and tumorlike lesions of the salivary gland. Arch Pathol Lab Med. 1994;118(10):994–7.

    CAS  PubMed  Google Scholar 

  389. Singhi AD, et al. Lymphoepithelial-like carcinoma of the oropharynx: a morphologic variant of HPV-related head and neck carcinoma. Am J Surg Pathol. 2010;34(6):800–5.

    PubMed  Google Scholar 

  390. Rao NA, et al. Lymphoepithelial carcinoma of the lacrimal gland. Arch Ophthalmol. 2002;120(12):1745–8.

    PubMed  Google Scholar 

  391. Liu YT, et al. Lymphoepithelial carcinoma of the lacrimal sac. Eye (Lond). 2009;23(7):1612–5.

    Google Scholar 

  392. Bloching M, Hinze R, Berghaus A. Lymphepithelioma-like carcinoma of the lacrimal gland. Eur Arch Otorhinolaryngol. 2000;257(7):399–401.

    CAS  PubMed  Google Scholar 

  393. Evans HL, Batsakis JG. Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplasm. Cancer. 1984;53(4):935–42.

    CAS  PubMed  Google Scholar 

  394. Selva D, et al. Polymorphous low-grade adenocarcinoma of the lacrimal gland. Arch Ophthalmol. 2004;122(6):915–7.

    PubMed  Google Scholar 

  395. Castle JT, et al. Polymorphous low grade adenocarcinoma: a clinicopathologic study of 164 cases. Cancer. 1999;86(2):207–19.

    CAS  PubMed  Google Scholar 

  396. Kemp BL, et al. Terminal duct adenocarcinomas of the parotid gland. J Laryngol Otol. 1995;109(5):466–8.

    CAS  PubMed  Google Scholar 

  397. Evans HL, Luna MA. Polymorphous low-grade adenocarcinoma: a study of 40 cases with long-term follow up and an evaluation of the importance of papillary areas. Am J Surg Pathol. 2000;24(10):1319–28.

    CAS  PubMed  Google Scholar 

  398. Wiwatwongwana D, et al. Unusual carcinomas of the lacrimal gland: epithelial-myoepithelial carcinoma and myoepithelial carcinoma. Arch Ophthalmol. 2009;127(8):1054–6.

    PubMed  Google Scholar 

  399. Ostrowski ML, et al. Clear cell epithelial-myoepithelial carcinoma arising in pleomorphic adenoma of the lacrimal gland. Ophthalmology. 1994;101(5):925–30.

    CAS  PubMed  Google Scholar 

  400. Singh G, et al. Epithelial-myoepithelial carcinoma of the lacrimal gland: a rare case. Ann Diagn Pathol. 2012;16(4):292–7.

    PubMed  Google Scholar 

  401. Chetty R. Intercalated duct hyperplasia: possible relationship to epithelial-myoepithelial carcinoma and hybrid tumours of salivary gland. Histopathology. 2000;37(3):260–3.

    CAS  PubMed  Google Scholar 

  402. Watt FM, Hogan BL. Out of Eden: stem cells and their niches. Science. 2000;287(5457):1427–30.

    CAS  PubMed  Google Scholar 

  403. Daa T, et al. Epithelial-myoepithelial carcinoma harboring p53 mutation. APMIS. 2001;109(4):316–20.

    CAS  PubMed  Google Scholar 

  404. Furuse C, et al. Beta-catenin and E-cadherin expression in salivary gland tumors. Int J Surg Pathol. 2006;14(3):212–7.

    CAS  PubMed  Google Scholar 

  405. Seethala RR, Barnes EL, Hunt JL. Epithelial-myoepithelial carcinoma: a review of the clinicopathologic spectrum and immunophenotypic characteristics in 61 tumors of the salivary glands and upper aerodigestive tract. Am J Surg Pathol. 2007;31(1):44–57.

    PubMed  Google Scholar 

  406. Tralongo V, Daniele E. Epithelial-myoepithelial carcinoma of the salivary glands: a review of literature. Anticancer Res. 1998;18(1B):603–8.

    CAS  PubMed  Google Scholar 

  407. Devoto MH, Croxatto JO. Primary cystadenocarcinoma of the lacrimal gland. Ophthalmology. 2003;110(10):2006–10.

    PubMed  Google Scholar 

  408. Peng X, et al. Papillary cystadenocarcinoma of the lacrimal gland. Ann Ophthalmol (Skokie). 2010;42 Spec No:15–9.

    Google Scholar 

  409. Foss RD, Ellis GL, Auclair PL. Salivary gland cystadenocarcinomas. A clinicopathologic study of 57 cases. Am J Surg Pathol. 1996;20(12):1440–7.

    CAS  PubMed  Google Scholar 

  410. De Rosa G, et al. Acinic cell carcinoma arising in a lacrimal gland. First case report. Cancer. 1986;57(10):1988–91.

    PubMed  Google Scholar 

  411. Jang J, et al. Acinic cell carcinoma of the lacrimal gland with intracranial extension: a case report. Ophthal Plast Reconstr Surg. 2001;17(6):454–7.

    CAS  PubMed  Google Scholar 

  412. Nichols AC, et al. A case report and genetic characterization of a massive acinic cell carcinoma of the parotid with delayed distant metastases. Case Rep Oncol Med. 2013;2013:270362.

    PubMed Central  PubMed  Google Scholar 

  413. Lewis JE, Olsen KD, Weiland LH. Acinic cell carcinoma. Clinicopathologic review. Cancer. 1991;67(1):172–9.

    CAS  PubMed  Google Scholar 

  414. Hoffman HT, et al. National Cancer Data Base report on cancer of the head and neck: acinic cell carcinoma. Head Neck. 1999;21(4):297–309.

    CAS  PubMed  Google Scholar 

  415. Piana S, et al. Dedifferentiated acinic cell carcinoma of the parotid gland with myoepithelial features. Arch Pathol Lab Med. 2002;126(9):1104–5.

    PubMed  Google Scholar 

  416. Muduly DK, et al. Basal cell adenocarcinoma of lacrimal gland. Orbit. 2011;30(6):300–2.

    PubMed  Google Scholar 

  417. Lee GA, Cominos D, Sullivan TJ. Clinicopathological report: mucinous carcinoma of the eyelid. Aust N Z J Ophthalmol. 1999;27(1):71–3.

    CAS  PubMed  Google Scholar 

  418. Uchida K, et al. Screening for DNA copy number aberrations in mucinous adenocarcinoma arising from the minor salivary gland: two case reports. Cancer Genet Cytogenet. 2010;203(2):324–7.

    CAS  PubMed  Google Scholar 

  419. Kalantzis G, et al. Oncocytic adenocarcinoma of the lacrimal gland: an unusual presentation. Eye (Lond). 2013;27(1):104–5.

    CAS  Google Scholar 

  420. Dorello U. Carcinoma oncocitario della ghiandola lacrimale. Riv Otoneurooftalmol. 1961;36:452–61.

    Google Scholar 

  421. Bernardini FP, Croxatto JO, Bandelloni R. Primary undifferentiated large cell carcinoma of the lacrimal gland. Ophthalmology. 2011;118(6):1189–92.

    PubMed  Google Scholar 

  422. Kivela T, Tarkkanen A. The Merkel cell and associated neoplasms in the eyelids and periocular region. Surv Ophthalmol. 1990;35(3):171–87.

    CAS  PubMed  Google Scholar 

  423. Gess AJ, Silkiss RZ. A merkel cell carcinoma of the lacrimal gland. Ophthal Plast Reconstr Surg. 2012;28(1):e11–3.

    PubMed  Google Scholar 

  424. Luaces Rey R, et al. Merkel cell carcinoma of the head and neck: report of seven cases. Med Oral Patol Oral Cir Bucal. 2008;13(6):E390–4.

    PubMed  Google Scholar 

  425. Feng H, et al. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096–100.

    CAS  PubMed Central  PubMed  Google Scholar 

  426. Iida K, et al. A case of malignant myoepithelioma in the lacrimal gland. Nihon Ganka Gakkai Zasshi. 2001;105(1):42–6.

    CAS  PubMed  Google Scholar 

  427. Cherian I, et al. Adenosquamous carcinoma of the lacrimal gland. BMJ Case Rep. 2010;2010:bcr0720103192.

    PubMed Central  PubMed  Google Scholar 

  428. Rasmussen P, et al. Malignant lymphoma of the lacrimal gland: a nation-based study. Arch Ophthalmol. 2011;129(10):1275–80.

    PubMed  Google Scholar 

  429. Farmer JP, et al. Lymphoproliferative lesions of the lacrimal gland: clinicopathological, immunohistochemical and molecular genetic analysis. Can J Ophthalmol. 2005;40(2):151–60.

    PubMed  Google Scholar 

  430. Sevel D. Development and congenital abnormalities of the nasolacrimal apparatus. J Pediatr Ophthalmol Strabismus. 1981;18(5):13–9.

    CAS  PubMed  Google Scholar 

  431. Tucker NA, Tucker SM, Linberg JV. The anatomy of the common canaliculus. Arch Ophthalmol. 1996;114(10):1231–4.

    CAS  PubMed  Google Scholar 

  432. Ipek E, et al. Morphological and morphometric evaluation of lacrimal groove. Anat Sci Int. 2007;82(4):207–10.

    PubMed  Google Scholar 

  433. Paul TO. Medical management of congenital nasolacrimal duct obstruction. J Pediatr Ophthalmol Strabismus. 1985;22(2):68–70.

    CAS  PubMed  Google Scholar 

  434. Nelson LR, Calhoun JH, Menduke H. Medical management of congenital nasolacrimal duct obstruction. Ophthalmology. 1985;92(9):1187–90.

    CAS  PubMed  Google Scholar 

  435. Petersen RA, Robb RM. The natural course of congenital obstruction of the nasolacrimal duct. J Pediatr Ophthalmol Strabismus. 1978;15(4):246–50.

    CAS  PubMed  Google Scholar 

  436. Perry LJ, et al. Giant dacryocystomucopyocele in an adult: a review of lacrimal sac enlargements with clinical and histopathologic differential diagnoses. Surv Ophthalmol. 2012;57(5):474–85.

    PubMed  Google Scholar 

  437. Welham RA, Bergin DJ. Congenital lacrimal fistulas. Arch Ophthalmol. 1985;103(4):545–8.

    CAS  PubMed  Google Scholar 

  438. Masi AV. Congenital fistula of the lacrimal sac. Arch Ophthalmol. 1969;81(5):701–4.

    CAS  PubMed  Google Scholar 

  439. Oill PA, et al. Specialty conference. Infectious disease emergencies. Part V: patients presenting with localized infections. West J Med. 1977;126(3):196–208.

    CAS  PubMed Central  PubMed  Google Scholar 

  440. Marthin JK, et al. Lesions of the lacrimal drainage system: a clinicopathological study of 643 biopsy specimens of the lacrimal drainage system in Denmark 1910–1999. Acta Ophthalmol Scand. 2005;83(1):94–9.

    PubMed  Google Scholar 

  441. Repp DJ, Burkat CN, Lucarelli MJ. Lacrimal excretory system concretions: canalicular and lacrimal sac. Ophthalmology. 2009;116(11):2230–5.

    PubMed  Google Scholar 

  442. Hay-Smith G, Rose GE. Lacrimal gland ductulitis caused by probable Actinomyces infection. Ophthalmology. 2012;119(1):193–6.

    PubMed  Google Scholar 

  443. Murphy CL, Murgatroyd H. Sarcoidosis of the lacrimal sac – an unusual case. Br J Ophthalmol. 2013;97:1351.

    PubMed  Google Scholar 

  444. Litwin AS, et al. Acquired lacrimal sac fistula mimicking basal cell carcinoma. Br J Dermatol. 2013;168(6):1348–50.

    CAS  PubMed  Google Scholar 

  445. Marcet MM, et al. Localized orbital amyloidosis involving the lacrimal sac and nasolacrimal duct. Ophthalmology. 2006;113(1):153–6.

    PubMed  Google Scholar 

  446. Kroll J, Busse H. Tumours of the lacrimal passages. Klin Monbl Augenheilkd. 2008;225(1):91–5.

    CAS  PubMed  Google Scholar 

  447. Golub JS, et al. Inverted papilloma of the nasolacrimal system invading the orbit. Ophthal Plast Reconstr Surg. 2007;23(2):151–3.

    PubMed  Google Scholar 

  448. Raemdonck TY, et al. Inverted papilloma arising primarily from the lacrimal sac. Orbit. 2009;28(2–3):181–4.

    PubMed  Google Scholar 

  449. Sjo NC, et al. Human papillomavirus: cause of epithelial lacrimal sac neoplasia? Acta Ophthalmol Scand. 2007;85(5):551–6.

    PubMed  Google Scholar 

  450. Stefanyszyn MA, et al. Lacrimal sac tumors. Ophthal Plast Reconstr Surg. 1994;10(3):169–84.

    CAS  PubMed  Google Scholar 

  451. Brar ST, Meyer D. Diagnosis and management of mucoepidermoid carcinoma of the lacrimal duct. Orbit. 2011;30(1):34–6.

    PubMed  Google Scholar 

  452. Brannan PA, et al. A case of primary adenocarcinoma of the lacrimal sac. Orbit. 2005;24(4):291–3.

    PubMed  Google Scholar 

  453. Baredes S, et al. Adenocarcinoma ex-pleomorphic adenoma of the lacrimal sac and nasolacrimal duct: a case report. Laryngoscope. 2003;113(6):940–2.

    PubMed  Google Scholar 

  454. De Stefani A, et al. Squamous cell carcinoma of the lacrimal drainage system: case report and literature review. Tumori. 1998;84(4):506–10.

    PubMed  Google Scholar 

  455. Kuwabara H, Takeda J. Malignant melanoma of the lacrimal sac with surrounding melanosis. Arch Pathol Lab Med. 1997;121(5):517–9.

    CAS  PubMed  Google Scholar 

  456. Li YJ, et al. Primary malignant melanoma of the lacrimal sac. BMJ Case Rep. 2012;2012:bcr006349.

    Google Scholar 

  457. Woo KI, Suh YL, Kim YD. Solitary fibrous tumor of the lacrimal sac. Ophthal Plast Reconstr Surg. 1999;15(6):450–3.

    CAS  PubMed  Google Scholar 

  458. Charles NC, Palu RN, Jagirdar JS. Hemangiopericytoma of the lacrimal sac. Arch Ophthalmol. 1998;116(12):1677–80.

    CAS  PubMed  Google Scholar 

  459. Bajaj MS, et al. Neurofibroma of the lacrimal sac. Orbit. 2002;21(3):205–8.

    PubMed  Google Scholar 

  460. Karcioglu ZA, editor. Orbital tumors diagnosis and treatment. New York: Springer; 2005.

    Google Scholar 

  461. Naumann GOH, Holbach LM, Kruse FE, editors. Applied pathology for ophthalmic microsurgeons. Berlin/New York: Springer; 2008.

    Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmic Pathology, Erasmus MC University, Rotterdam, The Netherlands

    Robert M. Verdijk MD, PhD

  2. Department of Experimental Medicine, University of Rome “Sapienza”, Rome, Italy

    Irene Pecorella MD, PhD

  3. Laboratory for Pathology, Dordrecht, The Netherlands

    Cornelia M. Mooy MD, PhD

Authors
  1. Robert M. Verdijk MD, PhD
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  2. Irene Pecorella MD, PhD
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  3. Cornelia M. Mooy MD, PhD
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Corresponding author

Correspondence to Robert M. Verdijk MD, PhD .

Editor information

Editors and Affiliations

  1. Eye Pathology Section Teilum-bygningen, University of Copenhagen, Copenhagen, Denmark

    Steffen Heegaard

  2. L.F. Montgomery Laboratory, Emory Eye Center, Atlanta, Georgia, USA

    Hans Grossniklaus

Additional information

All photographs were made by Robert M Verdijk and Irene Pecorella and that the authors wish to acknowledge Frank van der Panne for assistence in editing the figures.

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Verdijk, R.M., Pecorella, I., Mooy, C.M. (2015). The Orbit, Including the Lacrimal Gland and Lacrimal Drainage System. In: Heegaard, S., Grossniklaus, H. (eds) Eye Pathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43382-9_12

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