Summary
Polyinosinic-polycytidylic acid administered intraperitoneally inhibits the formation of chemically induced tumors by methylcholanthrene in mice. The experiments show that poly (I: C) is an effective suppressor of tumor formation when given simultaneously with the cancerogenic compound, or soon thereafter (before 4 weeks). Once the tumorigenesis was started (after 8 weeks), poly (I:C) treatment becomes ineffective.
The mechanism of inhibition of tumor formation by poly (I: C) was studied by measuring the immune response of treated mice. Mice treated with methylcholanthrene alone exhibit a 50% inhibition of the immune response towards sheep red blood cells. Animals injected with poly (I: C) after the methylcholanthrene treatment did not show any significant change. However, a pretreatment with poly (I: C) causes a complete reversal of immunosuppression caused by methylcholanthrene.
Zusammenfassung
Polyinosin-Polycytidylsäure (Poly I:C), intraperitoneal verabreicht, hemmt die Bildung von chemisch induzierten Tumoren durch Methylcholanthren in Mäusen. Die Versuche zeigen, daß Poly (I:C) ein wirksamer Hemmstoff der Tumorbildung ist, wenn es gleichzeitig mit Methylcholanthren oder bald danach (vor Ablauf von 4 Wochen) gegeben wird. Wenn die Tumorgenese einmal begonnen hat (nach 8 Wochen), wird die Poly (I:C)- Behandlung unwirksam.
Der Hemmungsmechanismus der Tumorbildung durch Poly (I:C) wurde durch Messung der Immunantwort von behandelten Mäusen untersucht. Nur mit Methylcholanthren behandelte Mäuse zeigen eine 50% ige Hemmung der Immunantwort in Gegenwart von Schaferythrocyten. Behandelt man die Tiere zuerst mit Methylcholanthren und anschließend mit Poly (I: C), so bleibt die Immunantwort unbeeinflußt. Ändert man diese Reihenfolge, indem das Poly (I: C) vor Methylcholanthren eingespritzt wird, so wird die immunsuppressive Wirkung des Methylcholanthrens vollkommen aufgehoben.
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Chandra, P., Gericke, D., Wacker, A. (1971). Effect of Polyinosinic-Polycytidylic Acid on Chemically induced Tumorigenesis by Methylcholanthrene in Mice. In: Hamperl, H., Hecker, E., Schmidt, C.G. (eds) Zeitschrift für Krebsforschung und klinische Onkologie / Cancer Research and Clinical Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-42449-0_4
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DOI: https://doi.org/10.1007/978-3-662-42449-0_4
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