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Aberrations Chromosomiques et Cancer

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Proceedings of the 9th International Cancer Congress

Part of the book series: UICC Monograph Series ((UICC,volume 9 ))

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Résumé

Depuis plus de soixante-dix ans l’on sait qu’il existe des aberrations chromosomiques dans les tissus cancéreux, mais les bouleversements sont si considérables qu’ils semblent défier toute description efficace. Le cytogénéticien se trouve ainsi dans la situation de l’héritier de Pascal; devant la profusion des documents et l’incertitude de beaucoup d’entre eux est-il possible de tenter leur analyse? mais peut-on négliger d’examiner pareille évidence?

C’est un héritier qui trouve les titres de sa maison. Dira-t-il: «Peut être qu’ils sont faux?» et négligera-t-il de les examiner? Pascal

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Bibliographie

  • Atkin, N. B., The influence of nuclear size and chromosome complement on prognosis of carcinoma of the cervix. Proc. roy. Soc. Med. 59, 979–982 (1966).

    PubMed  CAS  Google Scholar 

  • —, et Baker, M. C., A nuclear protrusion in a human tumor associated with an abnormal chromosome. Acta cytol. (Philad.) 8, 431–433 (1964).

    CAS  Google Scholar 

  • —, Mattison, G., et Baker, M. C., A comparison of the D. N. A. content and chromosome number of fifty human tumours. Brit. J. Cancer 20, 87–101 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Auersperg, N., Karyotype changes of near hexaploid carcinoma cells during adaptation in culture. Nature (Lond.) 212, 635–637 (1966).

    Article  CAS  Google Scholar 

  • Aula, P., Virus associated chromosome breakage. Ann. Acad. Sci. fenn. A 4 89 (1965).

    Google Scholar 

  • Berger, R., Chromosomes et leucémies humaines —., La notion d’évolution clonale. Ann. Génét. 8, 70–82 (1965).

    PubMed  CAS  Google Scholar 

  • Biedler, J. L., et Murphy M. L., A case of acute lymphoblastic leukemia associated with mongolism. Mammal. Chr. Newsl. 9, 23–24 (1963).

    Google Scholar 

  • Biesele, J. J., Chemically induced initiation of mitotic anomalies common to cancer cells. Ann. N. Y. Acad. Sci. 71, 1052–1067 (1958).

    Article  Google Scholar 

  • Bloom, G. E., Warber, S., Gerald, P. S., et Diamond, L. K., Chromosome abnormalities in constitutional aplastic anemia. New Engl. J. Med. 274, 8–14 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Borenfreund, E., Krim, M., Sanders, K., Sterberg, S. S., et Bendich, A., Malignant conversion of cells in vitro by carcinogens and viruses. Proc. nat. Acad. Sci. (Wash.) 56, 672–679 (1966).

    Article  CAS  Google Scholar 

  • Bottura, C., Ferrari, L, et Veiga, A. A., Chromosome abnormalities in Waldenstrom’s macroglobulinaemia. Lancet 1961 I, 1170.

    Article  Google Scholar 

  • Boveri, T., The origin of malignant tumor. Baltimore: Williams & Wilkins Co. 1929.

    Google Scholar 

  • Brookes, P., et Lawley, P. D., Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acides of mouse skin: Relation between carcinogenic power of hydrocarbons and their binding to deoxyribonucleic acid. Nature (Lond.) 202, 781–784 (1964).

    Article  CAS  Google Scholar 

  • Court Brown, W. M., et Tough, I. M., Cytogenetics studies in chronic myeloid leukemia. Advanc. Cancer Res. 7, 351–381 (1963).

    CAS  Google Scholar 

  • Denbeste, H. E., Fjelde, A., Jackson, J. L., Andersen, W. F., Kerr, H. A., et Evans, V. J., Adaptation, growth and chromosomal analysis of HEp-2 cells in chemically defined medium. J. nat. Cancer Inst. 36, 1075–1088 (1966).

    CAS  Google Scholar 

  • Dougan, L., Scott, I. D., et Woodliff, H. J., A pair of twins, one of whom has chronic granulocytic leukaemia. J. Med. Genet. 3, 217–219 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Fjelde, A., Levan, A., et Rask-Nielsen, R., The chromosomes of four transplantable murine plasma cell leukemias characterized by varying pathological serum protein changes and for amyloid formation. Hereditas (Lund) 48, 630–644 (1962).

    Google Scholar 

  • Ford, C. E., Selection presence in mammalian cell population. Symp. int. Soc. Cell Biol. 3, 27–45 (1964).

    Google Scholar 

  • Galton, M., Benirschke, K., Baker, M. C., et Atkin, N. B., Chromosomes in testicular teratomas. Cytogenetics 6, 261–275 (1966).

    Article  Google Scholar 

  • German, J., Archibald, R., et Bloom, D., Chromosomal breakage in a rare and probably genetically determined syndrome of man. Science 148, 506–507 (1965).

    Article  PubMed  CAS  Google Scholar 

  • German, J. L., Bird, C. E., et Bearn, A. G., Chromosomal abnormalities in Waldenstrom’s macroglobulinaemia. Lancet 1961 II, 48

    Article  Google Scholar 

  • German III, J. L., Evans, V. J., Cortner, J. A., et Westfall, B. B., Characterization of three human cell lines by chromosomal complement and by certain biochemical parameters. —., Reversible alteration of isozyme patterns by different media. J. nat. Cancer Inst. 32, 681–708 (1964).

    PubMed  Google Scholar 

  • Goh, K., et Swischer, S. N., Identical twins and chronic myelocytic leukemia. Arch intern. Med. 115, 475 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Grouchy, J. de, 3e Congr. Internat. de Génétique humaine, Chicago, Sept. 1966.

    Google Scholar 

  • —, Nava, C. de, Cantu, J. M., Bilski-Pasquier, G., et Bousser, J., Models for clonal evolutions: A study of chronic myelogenous leukemia. Amer. J. hum. Genet. 18, 485–503 (1966).

    PubMed  Google Scholar 

  • —, Zittoun, R., et Bousser, J., Analyses chromosomiques dans l’anémie sidéroblastique idiopathique acquise. — Une étude de six cas. Nouv. Rev. franç. Hêmat. 6, 367–388 (1966).

    PubMed  Google Scholar 

  • Haemmerli, G., Fjelde, A., Zweidler, A., et Strauli, P., Heterologous transplantation, chromosomes analysis and DNA measurements of the human carcinoma tissue culture line H. E. p 2. J. nat. Cancer Inst. 36, 673–683 (1966).

    PubMed  CAS  Google Scholar 

  • Hansemann, D. von, Über asymmetrische Zellteilung in Epithelkrebsen und deren biologische Bedeutung. Virchows Arch. path. Anat. 119, 299–326 (1890).

    Google Scholar 

  • Hellström, K. E., Hellström, I., et Sjögren, H. O., Karyotype and polyoma virus sensitivity in clones isolated from a polyoma — induced mouse tumor. J. nat. Cancer Inst. 32, 635–643 (1964).

    Google Scholar 

  • Holland, W. W., Doll, R., et Carter, C. O., The mortality from leukaemia and other cancers among patients with Down’s syndrome (mongols) and among their parents. Brit. J. Cancer 16, 177–186 (1962).

    Article  PubMed  CAS  Google Scholar 

  • Hsu, T. C., Chromosomal evolution in cell population. Int. Rev. Cytol. 12, 69–161 (1961).

    PubMed  CAS  Google Scholar 

  • Huehns, E. R., Lutzner, M., et Hecht, F., Nuclear abnormalities of the neutrophils in D 1 (13–15) Trisomy syndrome. Lancet 1964 I, 589–590

    Article  Google Scholar 

  • Ishihara, T., et Marino, J., Chromosomal conditions in some human subjects with non malignant diseases. Tex. Rep. Biol. Med. 18, 427–437 (1960).

    PubMed  CAS  Google Scholar 

  • Jacobs, P. A., Tough, I. M., et Wright, D. A., Cytogenetics studies in Burkitt’s lymphoma. Lancet 1963 I, 1144–1146.

    Article  Google Scholar 

  • Jerome, H., Effets biochimiques liés aux aberrations chromosomiques. In: Les Chromosomes humains par R. Turpin et J. Lejeune p. 407–428. Paris: Gauthier Villars.

    Google Scholar 

  • Kamada, N., Sur 50 cas de leucémie chez les survivants des bombardements d’Hiroshima et Nagasaki. Communication personelle. 1966.

    Google Scholar 

  • Kemp, N. H., Stafford, J. I., et Tanner, R., Aetiology of leukaemias. Lancet 1963 II, 95.

    Article  Google Scholar 

  • Kiossoglou, K. H., Rosenbaum, E., Mitus, W. J. et Dameshek, W., Multiple chromosome aberrations in Down’s syndrome associated with twinning in acute granulocytic leukaemia. Lancet 1963 II, 944–945.

    Article  Google Scholar 

  • Koprowski, H., Ponten, J., Jensen, F., Raudin, R. G., Moorhead, P., et Saksela, E., Transformation of cultures of human tissue infected with simian virus SV40. Acta Un. int. Cancr. 19, 362–367 (1963).

    PubMed  CAS  Google Scholar 

  • Lejeune, J., Rôle de la cytogénétique dans l’étude des processus néeoplasiques. Rev. Prat. (Paris) 13, L’Année du Praticien 21-23 (1963 a).

    Google Scholar 

  • —, Cit. in: Congenital malformation. Lancet 1963 b II, 189.

    Google Scholar 

  • —, Leucémie et cancer. In: Les chromosomes humains, par R. Turpin et J. Lejeune, p. 181–215. Paris: Gauthier-Villars 1965 a.

    Google Scholar 

  • —, Sur la théorie de l’évolution clonale du caryotype. Atti Convegni Farmitalia, Citogenetica délie Leucemie, p. 28–38. Torino: Minerva medica 1965b.

    Google Scholar 

  • Lejeune, J., Types et contretypes. In: Journées parisiennes de Pédiatrie, p. 73–83. Paris: Flammarion 1966.

    Google Scholar 

  • —, et Berger, R., Sur une méthode de recherche d’un variant commun des tumeurs de Povaire. C. R. Acad. Sci. (Paris) 262, 1885–1887 (1966).

    CAS  Google Scholar 

  • —, Caille, B. et Turpin, R., Evolution chromosomique d’une leucémie myéloide chronique. Ann. Génêt. 8, 44–49 (1965).

    PubMed  CAS  Google Scholar 

  • —, Haines, M., Lafourcade, J., Vialatte, J., Satge, P. et Turpin, R., Constitution d’un clone à 54 chromosomes au cours d’une leucoblastose chez une enfant mongolienne. C. R. Acad. Sci. (Paris) 256, 1195–1197 (1963).

    Google Scholar 

  • —, et Rethore, M. O., Sur l’endoréduplication sélective de certains segments du génome. C. R. Acad. Sci. (Paris) 263, 1880–1883 (1966).

    CAS  Google Scholar 

  • —, Gautier, M., et Turpin, R., Les chromosomes humains en culture de tissus. C. R. Acad. Sci. (Paris) 248, 602–603 (1959).

    CAS  Google Scholar 

  • Levan, A., Observations on the chromosomes of the Rous sarcoma in rats. Swed. Cancer Soc. Year Book 3, 247–249 (1963).

    Google Scholar 

  • Levin, R. H., Wang, J., Tjio, J. H., Carbone, P. P., Frei, E. III, et Freireich, E. J., Persistent mitosis of transfused homologous leucocytes in children receiving antileukemic therapy. Science 142, 1305–1311 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Marino, S., The chromosome cytology of the ascites tumors of rats with special reference to the concept of the stemline cell. Int. Rev. Cytol. 6, 25–84 (1957).

    Google Scholar 

  • —, Sasaki, M. S., et Fukuschina, T., Cytological studies of tumors. XVI —., Chromosomal instability in human chorionic lesions. Okajimas Folia anat. jap. 40, 439–465 (1965).

    Google Scholar 

  • Martineau, M., A similar marker chromosome in testicular tumors. Lancet 1966 I, 839.

    Article  Google Scholar 

  • McMichael, H., Wagner, J. E., Novell, P. C., et Hungerford, D. A., Chromosome studies of virus-induced rabbit papillomas and derived primary carcinomas. J. nat Cancer Inst. 31, 1197–1215 (1963).

    PubMed  CAS  Google Scholar 

  • Miller, R. W., Relation between cancer and congenital defects in man. New Engl. J. Med. 275, 87–93 (1966).

    Article  PubMed  CAS  Google Scholar 

  • —, Fraumeni, J. F., et Manning, M. D., Association of Wilm’s tumor with aniridia, hemihypertrophy, and other congenital malformations. New Engl. J. Med. 270, 922–927 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Mitelman, F., Preferential chromosome loss in a Rous rat sarcoma in response to environmental changes. Hereditas (Lund.) 54, 202–212 (1965).

    Article  CAS  Google Scholar 

  • Moorhead, P. J., Human tumor cell line with a quasi diploid karyotype (RPMI 2650). Exp. Cell Res. 39, 190–196 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Moorhead, P. S., et Saksela, E., Non random chromosomal aberrations in SV40 transformed human cells. J. cell. comp. Physiol. 62, 57–83 (1963).

    Article  CAS  Google Scholar 

  • Nichols, W. W., Relationships of viruses, chromosomes and carcinogenesis. Hereditas (Lund.) 50, 53–80 (1963).

    Article  Google Scholar 

  • —, Levan, A., Aula, P., et Norby, E., Chromosome damage associated with the measles virus in vitro. Hereditas (Lund.) 54, 101, 118 (1965).

    Google Scholar 

  • Norby, E., Levan, A., et Nichols, W. W., The correlation between the chromosome pulverization effect and other biological activities of measles virus preparations. Exp. Cell Res. 14, 483–491 (1966).

    Article  Google Scholar 

  • Nowell, P. C., et Hungerford, D. A., Chromosome studies on normal and leukaemic human leukocytes. J. nat. Cancer Inst. 25, 85–109 (1960).

    PubMed  CAS  Google Scholar 

  • Petersen, B., Karyotype profiles in chronic myelogenous leukemia. Influence of therapy and progression of disease. Acta path. microbiol. scand. 67, 463–478 (1966).

    Google Scholar 

  • Prunieras, M., Jacquemont, C., Chardonnet, Y. et Gazzolo, L., Etude sur les rapports virus-chromosome. VI Etude caryotypique du papillome de Shope. Ann. Inst. Pasteur 110, 145–174 (1966).

    Google Scholar 

  • Richart, R. M., et Wilbanks, G. D., The chromosomes of human intraepithelial neoplasias: report of 14 cases of cervical intraepithelial neoplasia and review. Cancer Res. 26, 60–74 (1966).

    PubMed  CAS  Google Scholar 

  • Robinson, A., Priest, R. E., et Bigler, P. C., Male pseudohermaphrodite XY/XO mosaicism and bilateral gonadoblastomas. Lancet 1964 I, 111–112.

    Article  Google Scholar 

  • Schade, H., Schoeller, L., et Schultze, K. W., D-Trisomie (Patau syndrome) mit kongenitaler myeloischer Leukämie. Med. Welt 1962, 2690-2692.

    Google Scholar 

  • Schmid, W. K., Scharer, Th. Baumann et Fanconi, G., Chromosomenbrüchigkeit bei der familiären Panmyelopathie (Typus Fanconi). Schweiz. med. Wsch. 95, 1461 (1965).

    CAS  Google Scholar 

  • Schrecker, A. W., Venditti, J. M., Greenberg, N. H., Biedler, J. L., Robinson, D. L., et Hutchinson, D. J., Association in increased dihydrofolate reductase levels and chromosome alteration in amethopterin resistant sublines of leukemia L 1210. J. nat. Canc. Inst. 31, 557–574 (1963).

    CAS  Google Scholar 

  • Schroeder, T. M., Cytogenetische und cytogische Befunde bei enzymopenischen Panmyelopathien und Pancytopenien. Humangenetik 2, 287–316 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Schunk, G. J., et Lehman, W. L., Mongolism and congenital leukaemia. J. Amer. med. Ass. 155, 250 (1954).

    Article  CAS  Google Scholar 

  • Schwartzenberg, L., Mathe, G., Grouchy, J. de, Nava, C. de, Vries, M. J. de, Amiel, J. L., Cattana, Schneider, M. et Schlumberger, J. R., Les transfusions de globules blancs. Bull. Soc. mêd. Hôp. Paris 116, 1699–1711 (1965).

    Google Scholar 

  • Spriggs, A. I., Boddington, M. M., et Clarke, C. M., Carcinoma in situ of the cervix uteri. Some cytogenetic observations. Lancet 1962 I, 1383.

    Article  Google Scholar 

  • Stewart, A., Aetiology of childhood malignancies, congenitally determined leukaemias. Brit. med. J. 1961 I, 452–460.

    Article  Google Scholar 

  • Stich, H. F., Proc. 4th Canad. Cancer Conf. 4, 99 (1962).

    Google Scholar 

  • Tjio, J. H., Carbone, P. P., Whang, J., et Frei III, E., The Philadelphia chromosome and chronic myelogenous leukemia. J. nat. Cancer Inst. 36, 567–584 (1966).

    PubMed  CAS  Google Scholar 

  • Tough, I.M., Court Brown, W.M., Baikie, A. G., Buckton, K. E., Harnden, D. G., Jacobs, P. A., and Williams, J. A., Chronic myeloid leukaemia: Cytogenetic studies before and after splenic irradiation. Lancet 1962, II, 115–120.

    Article  Google Scholar 

  • Tsuchida, R., et Rich, M. A., Chromosomal aberrations in viral leukemogenesis. I. Friend and Rauscher leukemia. J. nat. Cancer Inst. 33, 3347 (1964).

    Google Scholar 

  • Turpin, R., et Bernyer, G., De l’influence de Phérédité sur la formule d’Arneth (cas particulier du mongolisme). Rev. Hémat. 2, 189 (1947).

    Google Scholar 

  • Wald, H., Upton, A. C., Jenkins, V. K., et Borges, W. H., Radiation induced mouse leukemia: Consistent occurence of an extra and a marker chromosome. Science 143, 810–813 (1964).

    Article  PubMed  CAS  Google Scholar 

  • Warkany, J., Schubert, W. K., et Thomson, J. N., Chromosome analysis in mongolism (Langdon-Down syndrome) associated with leukemia. New Engl. J. Med. 268, 1–4 (1963).

    Article  PubMed  CAS  Google Scholar 

  • Whang, J., Frei III, E., Tjio, J. M., Carbone, P. P., et Brecher, G., The distribution of the Philadelphia chromosome in patients with chronic myelogenous leukemia. Blood 22, 664–673 (1963).

    PubMed  CAS  Google Scholar 

  • Winge, O., Zytologische Untersuchungen über die Natur maligner Tumoren. II Teerkarzinome bei Mäusen. Zellforsch. 10, 683–735 (1930).

    Article  Google Scholar 

  • Yoshida, T., et Ohara, K., Karyotypes in durg resistant sublines of mouse leukemia L 1210. A. R. Nat. Inst. Genet. Jap. 15, 58 (1965).

    Google Scholar 

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  1. Faculté de Médecine de Paris 15, rue de l’Ecole de Médecine, Paris 6e, France

    Jérôme Lejeune (Chaire de Génétique Fondamentale)

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  1. Jérôme Lejeune
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  1. Imperial Cancer Research Fund, Burtonhole Lane, London N.W.7, Great Britain

    R. J. C. Harris

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Lejeune, J. (1967). Aberrations Chromosomiques et Cancer. In: Harris, R.J.C. (eds) Proceedings of the 9th International Cancer Congress. UICC Monograph Series, vol 9 . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-41838-3_5

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