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On the mechanism of elevation of cardiac muscle functional capabilities in adaptation to exercise

Zum Mechanismus der Verbesserung der Leistungsfähigkeit des Herzens durch körperliches Training

  • Chapter
Experimental Cardiac Hypertrophy and Heart Failure

Summary

The main parameters of contraction and relaxation of papillary muscle strips taken from the left ventricle of control and exercise-adapted rats were measured. The isotonic peak shortening velocity and contraction amplitude of thin strips under low loads in adapted animals were 1.5 times higher compared to the corresponding controls.

In thick strips an even greater difference in parameters of isotonic contraction was observed — 2.3 times more. This change, together with 1.5 times higher maximal load corresponding to maximal developed tension, suggested the increased resistance to hypoxia in myocardial cells during adaptation. These results have been interpreted as being due to the well-known increase in the myosin ATP-ase activity as well as the adaptive augmentation of the functional power of oxygen and substrates transport system in myocardial cells.

The relaxation velocity of the adapted cardiac muscle increased even more than the contractile parameters; the relaxation index was higher as compared to the controls. It was suggested that the adaptation caused an augmentation in the calcium pump functional power. The myocardial compliance and the positive inotropic response to high frequency of stimulation were also elevated in adapted cardiac muscle. In total, the results suggest that an elevation of maximal myocardial performance caused by the exercise adaptation may be due to a coordinative augmentation of the functional power of the three main systems of myocardial cells — the ionic transport system, myosin ATPase and the ATP resynthesis system.

Dr. Pfeiffer worked in Moscow during a Scientific Mission from Physiology Institute, Berlin, German Democratic Republic.

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Authors and Affiliations

  1. The Laboratory of Pathophysiology, Institute of General Pathology and Pathophysiology, Academy of Medical Sciences, Moscow, USSR

    Prof. Dr. F. Z. Meerson, V. I. Kapelko & C. Pfeiffer

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  1. Prof. Dr. F. Z. Meerson
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  2. V. I. Kapelko
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  3. C. Pfeiffer
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  1. Tübingen, Germany

    Ruthard Jacob (Prof. Dr.) (Prof. Dr.)

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© 1980 Springer-Verlag Berlin Heidelberg

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Meerson, F.Z., Kapelko, V.I., Pfeiffer, C. (1980). On the mechanism of elevation of cardiac muscle functional capabilities in adaptation to exercise. In: Jacob, R. (eds) Experimental Cardiac Hypertrophy and Heart Failure. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-662-41468-2_32

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  • DOI: https://doi.org/10.1007/978-3-662-41468-2_32

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-7985-0577-3

  • Online ISBN: 978-3-662-41468-2

  • eBook Packages: Springer Book Archive

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