Radical Metabolism Is Partner to Energy Metabolism in Mitochondria

Part of the Annals of the New York Academy of Sciences book series (ANYAS, volume 1011)


It has been shown that cytochrome c plays a role in scavenging O2 and H2O2 in mitochondria through two electron leak pathways of the respiratory chain. Based on the two electron leak pathways and the Superoxide metabolic routes in nature, it is suggested that the concept of radical metabolism should be added as a partner to the energy metabolism of mitochondria. A total of four reactive pathways of Superoxide anion have been identified, collected, and linked to electron leaks in the respiratory chain. A view is presented that envisions mitochondria working on ATP synthesis by means of transferring electrons inside the respiratory chain while at the same time working on ROS generation and elimination as electrons leak out of the chain.


mitochondria radical metabolism Superoxide anion hydrogen peroxide cytochrome c 


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© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  1. 1.National Laboratory of Biomacromolecule, Center for Molecular Biology, Institute of BiophysicsChinese Academy of SciencesBeijingChina

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