Skip to main content
SpringerLink
Log in

Epidemiologic and Immunologic Considerations on the Pathogenesis of Burkitt’s Tumor

  • Chapter
Book cover Current Problems in the Epidemiology of Cancer and Lymphomas

  • 24 Accesses

Abstract

Burkitt’s Tumor (BT) is identified as a malignant lymphoma composed predominantly of lymphoid cells similar to those found in the germinal centers of lymphoreticular tissues under normal conditions of antigenic stimulation [1, 2, 3]. The normal cell that morphologically most closely resembles the Burkitt tumor cell is the germinoblast of Lennert [3, 4], and there may be only slight quantitative differences to a cell called immunoblast by Damashek [5] (Figs. 1-3).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 44.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 59.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Movat, H. Z., Fernando, N. V.: The fine structure of lymphoid tissue during antibody for¬mation. Exp. Molec. Path. 4, 155–188 (1965).

    Article  Google Scholar 

  2. World Health Organization. Histopathological definition of Burkitt’s Tumour. Bull. Wld. Health Org. 40, 601–607 (1969).

    Google Scholar 

  3. Lennert, K., Caesar, R., Muller, H. K.: Electron microscopic studies of germinal centers in man. pp. 49–59 in Germinal Centers in Immune Responses. Eds.: H. Cottier, N. Odart¬cI-Ienko, R. Schindler, and C. C. CoNCnoN. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  4. Mori, I., Lennert, K.: Electron Microscopic Atlas of Lymph Node Cytology and Pathology. Berlin-Heidelberg-New York: Springer 1969.

    Book  Google Scholar 

  5. Damashek, W.: Immunoblasts and Immunocytes — An attempt at a functional nomenclature. Blood 21, 243–245 (1963).

    Google Scholar 

  6. Burkitt, D. P., O’CoNoR, G. T.: Malignant lymphoma in African children. I. A clinical syn-drome. Cancer (Philad.) 14, 258–269 (1961).

    Article  CAS  Google Scholar 

  7. O’CoNoR, G. T.: Malignant lymphoma in African children. II. A pathological entity. Cancer (Philad.) 14, 270–283 (1961).

    Google Scholar 

  8. Burkitt, D. P.: A lymphoma syndrome dependent on environment. Part II. Epidemiological features. Symp. Lymph. Tumours in Africa, Paris 1963. Basel: Karger 1964, pp. 119–136.

    Google Scholar 

  9. Boom, K., Burkitt, D., Bassett, D. J., Cooke, R. A., Buddulph, J.: Burkitt lymphoma in Papua, New Guinea. Brit. J. Cancer 21, 657 (1967).

    Article  Google Scholar 

  10. Burkitt, D. P.: Recent developments in geographical distribution. pp. 36–41 in Treatment of Burkitt’s Tumour. Eds.: J. H. Burchenal and D. P. Burkitt. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  11. Burkirr, D. P., Davies, J. N. P.: Lymphoma syndrome in Uganda and tropical Africa. Afr. Med. Press 245, 367 (1961).

    Google Scholar 

  12. Bell, T. M.: Viruses associated with Burkitt’s tumor. Progr. med. Virol. 9, 1–34 (1967).

    CAS  Google Scholar 

  13. Epstein, M. A., Achong, B. G., Barr, Y. M.: Virus particles in cultured lymphoblasts from Burkitt’s lymphoma. Lancet 1964 I, 702.

    Article  PubMed  CAS  Google Scholar 

  14. Henle, G., Henle, W.: Immunofluorescence in cells derived from Burkitt’s lymphoma. J. Bact. 91, 1248 (1966).

    PubMed  CAS  Google Scholar 

  15. Old, L. J., Boyse, E. A., Oettgen, H. F., DE Harven, E., Geering, G., Williamson, B., Clifford, P.: Precipitating antibody in human serum to an antigen present in cultured Burkitt’s lymphoma cells. Proc. nat. Acad. Sci. (Wash.) 56, 1699–1704 (1966).

    Article  CAS  Google Scholar 

  16. Klein, G., Clifford, P., Klein, E., StjernswÄRD, J.: Search for tumor-specific immune reactions in Burkitt lymphoma patients by the membrane immunofluorescence reaction. Proc. nat. Acad. Sci. (Wash.) 55, 1628–1635 (1966).

    Article  CAS  Google Scholar 

  17. Goetz, O., Lampert, F., Peller, P., Prechtel, K.: Histologisch and virologisch gesicherter Burkitt-Tumor bei einem 10jährigen Knaben. Munch. med. Wschr. 112, 1373–1376 (1970).

    CAS  Google Scholar 

  18. Gallmeier, W. M., GÖBel, F. W., Hartung, W., Schmidt, C. G.: Studien an einem Burkitt¬Lymphom. Klin. Wschr. 48, 537–542 (1970).

    Article  PubMed  CAS  Google Scholar 

  19. Levine, P. H., O’CoNoR, G. T., Berard, C. W.: Antibodies to Ebstein-Barr virus (Ebv) in American patients with Burkitt’s lymphoma. Abstract, Spring Meeting, American Association for Cancer Research, St. Louis (1971).

    Google Scholar 

  20. Henle, W., Henle, G.: The relation between the Epstein-Barr virus and infectious mono¬nucleosis, Burkitt’s lymphoma and cancer of the postnasal space. Afr. med. J. 46, 402–413 (1969).

    CAS  Google Scholar 

  21. Levine, P. H., Ablashi, D. V., Berard, C. W., Carbone, P. P., Waggoner, D. E., Malan, L.: Elevated antibody-iters to Epstein-Barr virus in Hodgkin’s disease. Cancer (Philad.) 27, 416–421 (1971).

    Article  CAS  Google Scholar 

  22. Stevens, D. A., Fink, M. A., Pry, T. W., Maestri, N. E.: Prevalence of precipitating antibody to antigens derived from Burkitt’s lymphoma cultures infected with herpes type virus. Blood (in press).

    Google Scholar 

  23. Rauscher, F. J.: Virologie studies in human leukemia and lymphoma: The herpes-type virus. Cancer Res. 28, 1311 (1968).

    PubMed  Google Scholar 

  24. O’Connor, G. T., Dames, J. N. P.: Malignant tumours in African children with special reference to malignant lymphoma. J. Pediat. 56, 526–535 (1960).

    Google Scholar 

  25. Daldorf, G., Linsell, C. A., Barnhart, F. E., Martyn, R.: An epidemiologic approach to the lymphomas of African children and Burkitt’s sarcoma of the jaws. Perspect. Biol. Med. 7, 435–449 (1964).

    Google Scholar 

  26. Linsell, A.: Epidemiology of Burkitt’s tumour. Lancet 1967 I, 54.

    Article  Google Scholar 

  27. Burkitt, D. P.: Etiology of Burkitt’s lymphoma–an alternative hypothesis to a vectoral virus. J. nat. Cancer Inst. 42, 19–28 (1969).

    PubMed  CAS  Google Scholar 

  28. O’CoNoR, G. T.: Persistent immunologic stimulation as factor in oncogenesis, with special reference to Burkitt’s tumor. Amer. J. Med. 48, 279–285 (1970).

    Google Scholar 

  29. Kafuko, G. W., BuRxItt, D. P.: Burkitt’s lymphoma and malaria. Int. J. Cancer 6, 1–9 (1970).

    Google Scholar 

  30. Bell, T. M.: Review of the evidence for a viral aetiology for Burkitt’s lymphoma. In: Treatment of Burkitt’s Tumour. Eds.: J. H. Burchenal and D. P. Burkitt. Berlin-Heidelberg-New York: Springer 1967, pp. 52–58.

    Google Scholar 

  31. Stanley, N. F.: Reovirus type 3 and the etiology of Burkitt’s lymphoma. In: Treatment of Burkitt’s Tumour. Eds.: J. H. Burchenal and D. P. Burkitt. Berlin-Heidelberg-New York: Springer 1967, pp. 59–63.

    Google Scholar 

  32. Wedderburn, N.: Effect of concurrent malarial infection on development of virus-induced lymphoma in Balb/c mice. Lancet 1970 II, 1114–1116.

    Article  Google Scholar 

  33. KRÜGer, G.: Versuch einer immunologischen Deutung der Lymphomentstehung. Dtsch. Med. J. 21, 28–34 (1970).

    PubMed  Google Scholar 

  34. Mcgregor, T. A., Barr, M.: Antibody response to tetanus toxoid inoculation in malarious and non-malarious Gambian children. Trans. roy. Soc. trop. Med. Hyg. 56, 364–367 (1962).

    Article  Google Scholar 

  35. Salaman, M. H.: Immunodepression by mammalian viruses and plasmodia. Proc. roy. Soc. Med. 63, 11–15 (1970).

    CAS  Google Scholar 

  36. Greenwood, B. M., Playfair, J. H. L., Torrigiani, G.: Burkitt lymphoma and malaria. Lancet 1970 II, 418.

    Article  Google Scholar 

  37. Barker, L. R.: Immune responses in malaria. Lancet 1970 II, 819–820.

    Article  Google Scholar 

  38. Michaux, J. L.: Les immunoglobulins des Bantous a l’etat normal et pathologique. Ann. Soc. belge Méd. trop. 46, 483–674 (1966).

    PubMed  CAS  Google Scholar 

  39. KRÜGer, G.: Pathogenesis of lymphoreticular neoplasms in transplant recipients. Verh. dtsch. path. Ges. 54, 175–181 (1970).

    Google Scholar 

  40. Sizaret, P., O’CoNoR, G. T., Kretschmar, W., Beaumont, R., Laval, M.: Serum protein patterns in mice following primary and challenge infection with plasmodium berghei. Accepted for publication, Z. Tropenmed. Parasitol. (1971).

    Google Scholar 

  41. Jerusalem, C.: Relationship between malaria infection (plasmodium berghei) and malignant lymphoma in mice. Z. Tropenmed. Parasitol. 19, 94–108 (1968).

    PubMed  CAS  Google Scholar 

  42. KRitGer, G., Malmgren, R. A., Berard, C. W.: Malignant lymphomas and plasmacytosis in mice under prolonged immunosuppression and persistent antigenic stimulation. Transplant. 11, 138–144 (1971).

    Google Scholar 

  43. KRÜGer, G.: Impaired immunologic reactivity as pacemaker for lymphoma development. Verh. dtsch. path. Ges. 55, 200–204 (1971).

    Google Scholar 

  44. KRÜGer, G., Heine, U.: Morphogenesis of two immunologically induced mouse lymphomas. Submitted for publication (1971).

    Google Scholar 

  45. KRÜGer, G.: Host response during the latent period and the growth of an immunologically induced mouse lymphoma. Beitr. Path. Anat. (In print.)

    Google Scholar 

  46. Butler, J. J., Szakacs, A., Sinkovics, J. G.: Virus-induced murine lymphoma resembling Burkitt’s tumor. Amer. J. Path. 51, 629–637 (1967).

    PubMed  CAS  Google Scholar 

  47. Rappaport, H., Baroni, C.: A study of the pathogenesis of malignant lymphoma induced in the Swiss mouce by 7, 12-dimethylbenz (a) anthracene injected at birth. Cancer Res. 22, 1067 to 1074 (1962).

    Google Scholar 

  48. Kaplan, H. S.: Radiation-induced lymphoid tumors of mice. Acta Unio. Internat. Contra Caner. 7, 849–859 (1952).

    CAS  Google Scholar 

  49. Reske-Nielsen, E.: Neurologiske og neuropatologiske forandringer hos mus med trans¬plantabelt reticulosarcom. Aarhus: Universitetsforlaget 1961.

    Google Scholar 

  50. Kruger, G.: Continuous immunologic stimulation, immunosuppression, and lymphoma-genesis. Abstract, 3rd Internat. Congress of the Transplant. Soc., The Hague, Sept. 1970.

    Google Scholar 

  51. Goodheart, C. R.: Herpesviruses and cancer. J. Amer. med. Ass. 211, 91–96 (1970).

    Article  CAS  Google Scholar 

  52. Gerber, P., Whang-Peng, J., Monroe, J. H.: Transformation and chromosome changes induced by Epstein-Barr virus in normal human leukocyte cultures. Proc. nat. Acad. Sci. 63, 740–747 (1969).

    Google Scholar 

  53. Melendez, L. V.: Herpesvirus: II. Experimentally induced malignant lymphoma in primates. Lab. Animal Care 19, 378–386 (1969).

    CAS  Google Scholar 

  54. Huebner, R. J., Todaro, G. J., Sarma, P., Hartley, J. W., Freeman, A. E., Peters, R. L., Whitmire, C. E., Meier, H., Gilden, R. V.: “Switched-off” vertically transmitted C-type Rna tumor viruses as determinants of spontaneous and induced cancer: A new hypothesis of viral carcinogenesis. In: Defectiveness, Rescue and Stimulation of Oncogenic Viruses, pp. 33–57. (2nd Internat. Sympos. on Tumor Viruses, Royaumont, June 1969.) Editions du Centre National de la Recherche Scientifique, Paris 1970.

    Google Scholar 

  55. Rauscher, F. J.: A virus-induced disease of mice characterized by Erythocytopoiesis and lymphoid leukemia. J. nat. Cancer Inst. 29, 515–543 (1962).

    PubMed  CAS  Google Scholar 

  56. Theilen, G. H., Dungworth, D. L., Kawakami, T. G.: Experimental induction of lympho¬sarcoma in the cat with “C”-type virus. Cancer Res. 30, 401–408 (1970).

    PubMed  CAS  Google Scholar 

  57. E.B. virus, infectious mononucleosis, and Burkitt lymphoma. Lancet 1969 II, 887 to 888.

    Google Scholar 

  58. Myers, D. D., Meier, H., Huebner, R. J.: Prevalence of murine C-type virus group specific antigen in inbred strains of mice. Life Sci. 9, 1071–1080 (1970).

    Article  CAS  Google Scholar 

  59. Huebner, R. J., Todaro, G. J.: Oncogenes of Rna tumor viruses as determinants of cancer. Proc. nat. Acad. Sci. 64, 1087–1094 (1969).

    Article  CAS  Google Scholar 

  60. KRÜGer, G.: Morphology of chemical immunosuppression. Adv. Pharmacol. Chemother. 10, 1–90 (1972).

    Article  Google Scholar 

  61. Ceglowski, W. S., Friedman, H.: Immunosuppressive effects of Friend and Rauseher leukemia disease viruses on cellular and humoral antibody formation. J. nat. Cancer Inst. 40, 983–995 (1968).

    PubMed  CAS  Google Scholar 

  62. Salaman, M. H.: The effect of some leukemogenic viruses on immune reactions. In: Symp. Comp. Leukemia Res., Paris 1967, pp. 92–96. Bibl. haemat. 31. Basel: Karger 1968.

    Google Scholar 

  63. Wedderburn, N., Salaman, M. H.: The immunodepressive effect of Friend virus. II. Reduction of splenic hemolysin-producing cells in primary and secondary responses. Immunology 15, 439–454 (1968).

    PubMed  CAS  Google Scholar 

  64. Seidel, H. J., Lauenstein, K.: Zur immunosuppression durch Leukämieviren. Untersuchungen mit dem Rauscher-Virus an einem Leukämie-Resistenten Mäusestamm. Z. Krebsforsch. 72, 219–225 (1969).

    Article  PubMed  CAS  Google Scholar 

  65. Dent, P. B., Peterson, R. D. A., Good, R. A.: A defect in cellular immunity during the in¬cubation period of passage: A leukemia in C3H mice. Proc. Soc. exp. Biol. (N.Y.) 119, 869–871 (1965).

    Article  CAS  Google Scholar 

  66. Doell, R. G., DE Vaux, ST., Cyr, C., Grabar, P.: Immune reactivity prior to development of thymic lymphoma in C57B1 mice. Int. J. Cancer 2, 103–108 (1967).

    Article  PubMed  CAS  Google Scholar 

  67. Klein, G., Clifford, P., Henle, G., Henle, W., Geering, G., Old, L. J.: Ebv-Associated serological patterns in a Burkitt lymphoma patient during regression and recurrence. Int. J. Cancer 4, 416–421 (1969).

    Article  PubMed  CAS  Google Scholar 

  68. Ziegler, J. L., Cohen, M. H., Morrow, R. H., Kyalwazi, S. K., Carbone, P. P.: Immunologic studies in Burkitt’s lymphoma. Cancer (Philad.) 25, 734–739 (1970).

    Article  CAS  Google Scholar 

  69. Fass, L., Herberman, R. B., Ziegler, J.: Delayed cutaneous hypersensitivity reactions to auto¬logous extracts of Burkitt-lymphoma cells. New Engl. J. Med. 282, 776–780 (1970).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA

    Gerhard Krüger & Gregory T. O’Conor

Authors
  1. Gerhard Krüger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gregory T. O’Conor
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institute of Pathology, University of Münster, D-44, Münster, Germany

    E. Grundmann

  2. International Agency for Research on Cancer, World Health Organization, Lyon, France

    H. Tulinius

Rights and permissions

Reprints and permissions

Copyright information

© 1972 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Krüger, G., O’Conor, G.T. (1972). Epidemiologic and Immunologic Considerations on the Pathogenesis of Burkitt’s Tumor. In: Grundmann, E., Tulinius, H. (eds) Current Problems in the Epidemiology of Cancer and Lymphomas. Recent Results in Cancer Research / Fortschritte der Krebsforschung / Progrès dans les recherches sur le cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-41032-5_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-41032-5_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-40553-6

  • Online ISBN: 978-3-662-41032-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation