The Aflatoxins and Human Liver Cancer
The possible role of natural and synthetic chemical carcinogens in the aetiology of human liver cancer has been reviewed recently by Magee (1971). The synthetic chemical carcinogens generally have little relation to the situation in man and remain laboratory shelf carcinogens with the interesting exception of the nitrosamines. The possibilities among the natural carcinogens, however, appears more promising and the pyrrolizidine alkaloids from Senecio and Crotalaria plants, the glycosides from the cycads, the toxic agents from rice contaminated by Penicillium islandicum, and the aflatoxins from the Aspergillus moulds have been the subject of much endeavour during the last decade.
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