An Immunological Analysis of Three Cases of Bone Marrow Failure Associated with Campath-I-Incubation
T-cell purging is effective in preventing GvHD but increases the risk of graft failure (1). We have observed two cases of graft rejection and one episode of reversible bone marrow hypoplasia in three leukaemic patients who had received a HLA-identical graft incubated with Campath-I. An analysis of the mechanism of rejection has been performed using immunological techniques and stem cell culture technology.
KeywordsGraft Failure Graft Rejection Bone Marrow Mononuclear Cell Donor Bone Marrow Hemopoietic Stem Cell
- (1).Martin PJ, Hansen JA, Storb, R, et al. Depletion of T cells in donor marrow for prevention of graftversus-host disease. Abstracts of the 10th international Congress of the Transplantation Society 1984; 5.376: 249Google Scholar