An Immunological Analysis of Three Cases of Bone Marrow Failure Associated with Campath-I-Incubation

  • D. Bunjes
  • M. Wiesneth
  • Th. Schmeiser
  • R. Arnold
  • W. Heit
Part of the Experimental Hematology book series (HEMATOLOGY)

Abstract

T-cell purging is effective in preventing GvHD but increases the risk of graft failure (1). We have observed two cases of graft rejection and one episode of reversible bone marrow hypoplasia in three leukaemic patients who had received a HLA-identical graft incubated with Campath-I. An analysis of the mechanism of rejection has been performed using immunological techniques and stem cell culture technology.

Keywords

Preven Pancytopenia 

References

  1. (1).
    Martin PJ, Hansen JA, Storb, R, et al. Depletion of T cells in donor marrow for prevention of graftversus-host disease. Abstracts of the 10th international Congress of the Transplantation Society 1984; 5.376: 249Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • D. Bunjes
    • 1
  • M. Wiesneth
    • 1
  • Th. Schmeiser
    • 1
  • R. Arnold
    • 1
  • W. Heit
    • 1
  1. 1.Department of Internal Medicine IIIUniversity of UlmUlmFederal Republic of Germany

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