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In vitro Marrow Purging with Anti-DR Monoclonal Antibodies and Complement in High Dose Risk ALL

Preclinical Studies and Preliminary Clinical Experience
  • Dominique Maraninchi
  • Claude Mawas
  • Brynhild Mascret
  • Gérard Sebahoun
  • Jean-Albert Gastaut
  • Nicole Tubiana
  • Henri Perrimond
  • Joelle Scavennec
  • Gisèle Novakovitch
  • Yves Carcassonne
Part of the Experimental Hematology book series (HEMATOLOGY)

Abstract

  • Human DR antigens are histocompatibility antigens close to the Ia murine antigens. In mice, la is not expressed on CFU-S, but is present on more differenciated progenitors CFU-GM and BFU-E (1).

  • DR is expressed to the membrane of most of the non T lymphoid malignancies (2)- Anti DR Mo Ab could have large clinical indications to treat residual marrow leukemic contamination of such patients with the aim of autologous BMT.

  • DR is expressed in man on GM-CFC, BFU-E and CFU-GEMM (3) suggesting that in vitro marrow treatment with anti DR monoclonal antibodies could affect haematological reconstitution after marrow transplantation.

Keywords

Lymphoid Malignancy Human Bone Marrow Cell Treatment Monoclonal Antibody Human Hematopoietic Progenitor Cell Granulocytic Precursor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. (1).
    BASCH R.S., JANOSSY G, GREAVES M.F., Murine pluripotential stem cells lack Ia antigen, Nature 270: 520, 1977PubMedCrossRefGoogle Scholar
  2. (2).
    NADLER L.M., RITZ J., GRIFFIN J.D. et al, Diagnosis and treatment of human leukemia and lymphoma utilizing monoclonal antibodies Progress in Hematology 12: 187–226, 1981Google Scholar
  3. (3).
    FITCHEN J.H., LEFEVRE C., FERRONE S. et al Expression of Ia like and HLA A-B antigens on human pluripotential haematopoïetic progenitor cells. Blood 59: 188, 1982PubMedGoogle Scholar
  4. (4).
    GARTNER S., KAPLAN H.S., Long term culture of human bone marrow cells PNAS 77: 4756, 1980Google Scholar
  5. (5).
    REBAI N., MALISSEN B., PIERES M. et al Distinct HLA-DR epitopes and distinct families of HLA DR molecules defined by 15 either anti DR or allo anti Ia K cross reacting with human cells. Eur. J. Immunology 1306, 1983Google Scholar
  6. (6).
    FALKENBURG J.H.F., JANSEN J., V. der VAARTDUINKERKEN N. et al, Polymorphic and monomorphic HLA-DR determinants on human hematopoletic progenitor cells. Blood 63, 1125, 1984PubMedGoogle Scholar
  7. (7).
    KEATING A., POWELL J., TAKAHOSI M. et al The generation of human long term marrow cultures from marrow depleted of Ia (HLA-DR) positive cells Blood 64: 1159–1162, 1984PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Dominique Maraninchi
    • 5
  • Claude Mawas
    • 1
  • Brynhild Mascret
    • 5
  • Gérard Sebahoun
    • 5
  • Jean-Albert Gastaut
    • 5
  • Nicole Tubiana
    • 5
  • Henri Perrimond
    • 2
  • Joelle Scavennec
    • 3
  • Gisèle Novakovitch
    • 4
  • Yves Carcassonne
    • 5
  1. 1.Unité 119 INSERMMarseilleFrance
  2. 2.Service de Pédiatrie ACHU TimoneMarseilleFrance
  3. 3.Société ImmunotechMarseilleFrance
  4. 4.Regional Blood BankMarseilleFrance
  5. 5.Marrow Transplant Unit, Clinique des Maladies du SangInstitut Paoli-CalmettesMarseilleFrance

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