Part of the
book series (HEMATOLOGY)
Marrow Transplantation for Advanced Leukemia in Patients Over 30 Years with Fractionated TBI
A Randomized Trial of MTX and Cyclosporine
Bone marrow transplantation(BMT)for leukemia in relapse is often complicated by severe transplant-related toxicities, which are increasing with age, and result in a high mortality. Among the surviving patients, the relapse frequency is elevated (1, 2). The present study was designed to determine the effects of fractionated total body irradiation (TBI, 7 fractions of 2.25 Gy delivered at a rate of 6.5 cGy/min over 7 conscutive days) and Methotrexate (MTX) or Cyclosporine (CSP) immunosuppression, on the outcome of BMT in 56 consecutive patients over 30 years of age with relapsed leukemia.
KeywordsBone Marrow Transplantation Relapse Rate Total Body Irradiation Severe Mucositis Mental Depression
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