Marrow Transplantation for Advanced Leukemia in Patients Over 30 Years with Fractionated TBI

A Randomized Trial of MTX and Cyclosporine
  • C. Irle
  • H. J. Deeg
  • C. D. Buckner
  • M. Kennedy
  • R. Storb
  • R. A. Clift
  • E. D. Thomas
Part of the Experimental Hematology book series (HEMATOLOGY)

Abstract

Bone marrow transplantation(BMT)for leukemia in relapse is often complicated by severe transplant-related toxicities, which are increasing with age, and result in a high mortality. Among the surviving patients, the relapse frequency is elevated (1, 2). The present study was designed to determine the effects of fractionated total body irradiation (TBI, 7 fractions of 2.25 Gy delivered at a rate of 6.5 cGy/min over 7 conscutive days) and Methotrexate (MTX) or Cyclosporine (CSP) immunosuppression, on the outcome of BMT in 56 consecutive patients over 30 years of age with relapsed leukemia.

Keywords

Toxicity Depression Leukemia Pneumonia Methotrexate 

References

  1. 1.
    Appelbaum F.R., Clift R.A., Buckner C.D. et al Blood 61, 949 (1983)PubMedGoogle Scholar
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    Buckner C.D., Clift R.A., Thomas E.D., et al Leuk.Res. 6, 389 (1982)PubMedCrossRefGoogle Scholar
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    Irlé C., Deeg H.J., Buckner C.D. et al. Leuk.Res., in press.Google Scholar
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    Meyers J.D., Flournoy N., Wade J.C., Hackman R.C. et al. In: Gale RP ed. Recent Advances in Bone Marrow Transplantation 405 (1983).Google Scholar
  5. 5.
    McDonald G.B., Sharma P., Matthews D.E. et al. Hepatology 4, 116 (1984).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • C. Irle
    • 1
    • 2
    • 3
    • 4
  • H. J. Deeg
    • 1
    • 2
    • 3
    • 4
  • C. D. Buckner
    • 1
    • 2
    • 3
    • 4
  • M. Kennedy
    • 1
    • 2
    • 3
    • 4
  • R. Storb
    • 1
    • 2
    • 3
    • 4
  • R. A. Clift
    • 1
    • 2
    • 3
    • 4
  • E. D. Thomas
    • 1
    • 2
    • 3
    • 4
  1. 1.Division of OncologyThe Fred Hutchinson Cancer Research CenterUSA
  2. 2.The Swedish Hospital Medical CenterUSA
  3. 3.The Seattle Veterans Administration HospitalUSA
  4. 4.The University of Washington School of Medicine SeattleUSA

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