Different DQw2 Are Associated with DR3 and DR7 as Revealed by RFLP Analysis

  • P. Avoustin
  • H. L. Coppin
  • A. Zerbib
  • A. Cambon-Thomsen
  • M. Thomsen
  • J. Tkaczuk
  • E. Ohayon
  • C. de Preval

Abstract

HLA-DQ antigens were first characterized by serologic assays. Three types of HLA-DQ alloantigens have been defined: HLA-DQw1, -DQw2, -DQw3. At the genomic level, two genes encoding the α chain (αDQ, αDX) and the β chain (βDQ, βDX) have been identified within the HLA DQ region of the major histocompatibility complex. The DQw2 specificity is in strong linkage disequilibrium with HLA-DR3 and -DR7 alleles. Recently, biochemical studies and RFLP analysis allowed the split of HLA-DQw1 and DQw3 types in several subgroups (1). Immunoprecipitation and two-dimensional gel analysis revealed a βDQ chain polymorphism between DQw2 molecules isolated either from cells bearing DR3 or DR7, DQw2 haplotypes.

Keywords

Serine Polypeptide Leucine Librium Isoleucine 

References

  1. 1.
    Bontrop RE, Baas EJ, Otting NO, Schreuder GMT, Giphart MJ. DQ alpha and beta chain isoelectric point differences and their relations to serologically defined HLA-DQ allospecificities. Immunogenetics 1987; 25: 305–312.PubMedCrossRefGoogle Scholar
  2. 2.
    Wescott MZ, Wdeh ZL, Yunis EJ, Alper CA. Molecular analysis distinguishes two HLA-DR3 bearing major histocompatibility complex extended haplotypes. Immunogenetics 1987; 26: 370–374.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • P. Avoustin
    • 1
  • H. L. Coppin
    • 1
  • A. Zerbib
    • 1
  • A. Cambon-Thomsen
    • 1
  • M. Thomsen
    • 1
  • J. Tkaczuk
    • 1
  • E. Ohayon
    • 1
  • C. de Preval
    • 1
  1. 1.Inserm U100CedexFrance

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