Different DQw2 Are Associated with DR3 and DR7 as Revealed by RFLP Analysis
HLA-DQ antigens were first characterized by serologic assays. Three types of HLA-DQ alloantigens have been defined: HLA-DQw1, -DQw2, -DQw3. At the genomic level, two genes encoding the α chain (αDQ, αDX) and the β chain (βDQ, βDX) have been identified within the HLA DQ region of the major histocompatibility complex. The DQw2 specificity is in strong linkage disequilibrium with HLA-DR3 and -DR7 alleles. Recently, biochemical studies and RFLP analysis allowed the split of HLA-DQw1 and DQw3 types in several subgroups (1). Immunoprecipitation and two-dimensional gel analysis revealed a βDQ chain polymorphism between DQw2 molecules isolated either from cells bearing DR3 or DR7, DQw2 haplotypes.
KeywordsSerine Polypeptide Leucine Librium Isoleucine