Abstract
HLA-DQ antigens were first characterized by serologic assays. Three types of HLA-DQ alloantigens have been defined: HLA-DQw1, -DQw2, -DQw3. At the genomic level, two genes encoding the α chain (αDQ, αDX) and the β chain (βDQ, βDX) have been identified within the HLA DQ region of the major histocompatibility complex. The DQw2 specificity is in strong linkage disequilibrium with HLA-DR3 and -DR7 alleles. Recently, biochemical studies and RFLP analysis allowed the split of HLA-DQw1 and DQw3 types in several subgroups (1). Immunoprecipitation and two-dimensional gel analysis revealed a βDQ chain polymorphism between DQw2 molecules isolated either from cells bearing DR3 or DR7, DQw2 haplotypes.
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Bontrop RE, Baas EJ, Otting NO, Schreuder GMT, Giphart MJ. DQ alpha and beta chain isoelectric point differences and their relations to serologically defined HLA-DQ allospecificities. Immunogenetics 1987; 25: 305–312.
Wescott MZ, Wdeh ZL, Yunis EJ, Alper CA. Molecular analysis distinguishes two HLA-DR3 bearing major histocompatibility complex extended haplotypes. Immunogenetics 1987; 26: 370–374.
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© 1989 Springer Science+Business Media New York
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Avoustin, P. et al. (1989). Different DQw2 Are Associated with DR3 and DR7 as Revealed by RFLP Analysis. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_99
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DOI: https://doi.org/10.1007/978-3-662-39946-0_99
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38980-5
Online ISBN: 978-3-662-39946-0
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