Abstract
The class III region of the HLA complex is located between the class I and class II regions. Whereas HLA class I and class II genes encode sets of structurally related, highly polymorphic transplantation antigens, the class III region consists of at least four types of genes, only two of which have obvious functions in the immune system. Unlike the highly polymorphic class I and II genes, class III genes display a low to moderate degree of genetic variability, but are nevertheless subject to evolutionary mechanisms observed elsewhere in the HLA complex, including gene conversions and changes in gene copy number due to unequal crossing-over during meiosis.
Keywords
- Congenital Adrenal Hyperplasia
- CYP21 Gene
- CYP21B Gene
- Tumor Necrosis Factor Gene
- Congenital Adrenal Hyper
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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White, P.C. (1989). Molecular Genetics of the Class III Region of the HLA Complex. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_6
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DOI: https://doi.org/10.1007/978-3-662-39946-0_6
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