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Two Different T-Cell Perspectives on the DR1 Alloantigen

  • David D. Eckels
  • Thomas W. Sell
  • Jay B. Hunter
  • Susan A. Hackbarth

Abstract

Exposure to thymic MHC molecules may influence the T-cell allorecognition repertoire. Therefore, since we have observed such a plethora of distinct fine specificities in alloreactive T-cell clones1,2, we postulated that T cells derived from allogeneic donors might recognize alloantigens with different fine specificities. To test this hypothesis, three series of alloreactive T-cell clones were derived by limiting dilution as previously described (1): series 61 (DR2;DRw13 anti-DR1); series 62 (DR2;DRw14 anti-DR1;DR2s); series 63 (DR2;DRw13 anti-DR1;DR2s). DR1-associated allodeterminants should have been primarily recognized because DQ and DP antigens were shared. However, T cells from series 62 would have differentiated in the presence of DR2 and DRw14, whereas those from series 61 and 63 would have developed in the presence of DR2 and DRw13.

Keywords

Mixed Lymphocyte Reaction Priming Series American Black Allogeneic Donor eDNA Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Rosen-Bronson S, Johnson AH, Hartzman RJ, Eckels DD. Immunogenetics 1986; 23: 368.PubMedCrossRefGoogle Scholar
  2. 2.
    Eckels DD, Hartzman RJ. Immunogenetics 1982; 16: 117.PubMedCrossRefGoogle Scholar
  3. 3.
    Mendell NR, Lee KL, Reinsmoen N, Yunis E, Amos B, Emme L. Transplant Proc 1977; 9: 99.PubMedGoogle Scholar
  4. 4.
    Lamb JR, Eckels DD, Lake P, Woody JN, Green N. Nature 1982; 300: 66.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • David D. Eckels
    • 1
  • Thomas W. Sell
    • 1
  • Jay B. Hunter
    • 1
  • Susan A. Hackbarth
    • 1
  1. 1.Immunogenetics Research SectionBlood Center SE WisconsinMilwaukeeUSA

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