Differential Regulation of HLA B Antigen Expression by Interferon

  • Helmuth Schmidt
  • Hans-Jörg Bühring
  • Gabriele Engler Blum
  • Ulrike Reichmann
  • Claudia Müller
  • Elisabeth Weiss
  • Volker Gekeler

Abstract

Quantitative differences in the expression of HLA antigens have been shown to influence T-cell mediated immune responses. On murine lymphocytes and thymocytes (1), as well as on human cell lines (2), differential expression of MHC class I antigens has been described. For further insight into regulation of HLA class I antigen expression, DNA-mediated gene transfer has been applied. L(tk) cells transfected with the genes coding for the heavy chain of the HLA-A2 and -B7 antigen revealed a two to three times more increased expression of the HLA-B compared to the HLA-A locus molecule after stimulation with mouse interferon (3).

Keywords

Lymphoma Interferon Thymidine Gout Hypoxanthin 

References

  1. 1.
    Tartakovsky B, De Baetselier P, Segal S. Serological detection of H-2K- and H-2D-gene products: Principal differences between T and B lymphocytes in expression of H-2D-encoded alloantigens. Immunogenetics 1980; 11: 585.PubMedCrossRefGoogle Scholar
  2. 2.
    Burrone OR, Kefford RF, Gilmore D, Milstein C. Stimulation of HLA-A,B,C by IFN-alpha. The derivation of Molt 4 variants and the differential expression of HLA-A,B,C subsets. EMBO J 1985; 4: 2855.Google Scholar
  3. 3.
    Schmidt H, Forsthuber T, Bühring H-J, Müller CA. Differential expression of the HLA-B7 and the HLA-A2 gene in transfected mouse L(tk) cells after stimulation by mouse interferon. Immunobiol 1987; 174: 51.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Helmuth Schmidt
    • 1
  • Hans-Jörg Bühring
    • 1
  • Gabriele Engler Blum
    • 1
  • Ulrike Reichmann
    • 1
  • Claudia Müller
    • 1
  • Elisabeth Weiss
    • 2
  • Volker Gekeler
    • 3
  1. 1.Medizinische KlinikTübingenGermany
  2. 2.Institut für ImmunologieMünchenGermany
  3. 3.Physiologisch-Chemisches InstitutTübingenGermany

Personalised recommendations