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Differential Regulation of HLA B Antigen Expression by Interferon

  • Helmuth Schmidt
  • Hans-Jörg Bühring
  • Gabriele Engler Blum
  • Ulrike Reichmann
  • Claudia Müller
  • Elisabeth Weiss
  • Volker Gekeler

Abstract

Quantitative differences in the expression of HLA antigens have been shown to influence T-cell mediated immune responses. On murine lymphocytes and thymocytes (1), as well as on human cell lines (2), differential expression of MHC class I antigens has been described. For further insight into regulation of HLA class I antigen expression, DNA-mediated gene transfer has been applied. L(tk) cells transfected with the genes coding for the heavy chain of the HLA-A2 and -B7 antigen revealed a two to three times more increased expression of the HLA-B compared to the HLA-A locus molecule after stimulation with mouse interferon (3).

Keywords

Author Affiliation Murine Lymphocyte Mouse Interferon Natural Killer Target Natural Killer Susceptibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Tartakovsky B, De Baetselier P, Segal S. Serological detection of H-2K- and H-2D-gene products: Principal differences between T and B lymphocytes in expression of H-2D-encoded alloantigens. Immunogenetics 1980; 11: 585.PubMedCrossRefGoogle Scholar
  2. 2.
    Burrone OR, Kefford RF, Gilmore D, Milstein C. Stimulation of HLA-A,B,C by IFN-alpha. The derivation of Molt 4 variants and the differential expression of HLA-A,B,C subsets. EMBO J 1985; 4: 2855.Google Scholar
  3. 3.
    Schmidt H, Forsthuber T, Bühring H-J, Müller CA. Differential expression of the HLA-B7 and the HLA-A2 gene in transfected mouse L(tk) cells after stimulation by mouse interferon. Immunobiol 1987; 174: 51.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Helmuth Schmidt
    • 1
  • Hans-Jörg Bühring
    • 1
  • Gabriele Engler Blum
    • 1
  • Ulrike Reichmann
    • 1
  • Claudia Müller
    • 1
  • Elisabeth Weiss
    • 2
  • Volker Gekeler
    • 3
  1. 1.Medizinische KlinikTübingenGermany
  2. 2.Institut für ImmunologieMünchenGermany
  3. 3.Physiologisch-Chemisches InstitutTübingenGermany

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