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Immunoregulatory Circuits Initiated by Autoreactive T Cell Clones: I. Generation of T Helper, T Amplifier, and T Suppressor Clones

  • Niciole Suciu-Foca
  • Elaine Reed
  • Elena Cristea
  • Donald W. King

Abstract

The idiotype network postulates that T- and B-cell clones are interconnected through idiotypic determinants borne by the immune receptor. Because the antigen receptor of T cells, like the Ig receptor of B cells, is clonally distributed, the idiotypes characterizing one clone can stimulate the proliferation of another clone bearing complementary anti-idiotypic receptors. In previous studies (1–3), we provided evidence supporting this concept by demonstrating that (allo) antigenspecific T cells trigger the production of autoantibodies and of autoreactive (i.e., AMLC-reactive) anti-idiotypic T cells. We now document the existence of anti-idiotypic T-cell clones with helper, amplifier, suppressor, and suppressor/amplifier function.

Keywords

Mixed Lymphocyte Culture Idiotype Network Blastogenic Response Mixed Lymphocyte Culture Reactivity Autologous Peripheral Blood Lymphocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Suciu-Foca N, Reed E, Rohowsky C, Kung P, King DW. Anti-idiotypic antibodies to anti-HLA receptors induced by pregnancy. Proc Natl Acad Sci USA 1983; 80: 830–834.PubMedCrossRefGoogle Scholar
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    Suciu-Foca N, Rohowsky C, Kung P, and King DW. Idiotypic-like determinants on human T lymphocytes alloactivated in mixed lymphocyte culture (MLC). J Exp Med 1982; 156: 283–288.PubMedCrossRefGoogle Scholar
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    Rohowsky C, Suciu-Foca N, Kung P, Tang TF, Reed E, King DW. Suppressor T cells generated in autologous MLR with activated T lymphoblasts. Transplant Proc 1983; 15 (1): 765–770.Google Scholar
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    Suciu-Foca N, Rohowsky C, Kung P, King DW. Idiotypic receptors for soluble antigens on human T-lymphocytes clones. Human Immunol 1984; 93: 34–47.Google Scholar
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    Yoshikai Y, Yanagi Y, Suciu-Foca N, Mak TW. Presence of T cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation. Nature 1984; 310: 506–508.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Niciole Suciu-Foca
    • 1
  • Elaine Reed
    • 1
  • Elena Cristea
    • 1
  • Donald W. King
    • 2
  1. 1.Department of PathologyCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA
  2. 2.Department of PathologyUniversity of ChicagoChicagoUSA

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