Immunoregulatory Circuits Initiated by Autoreactive T Cell Clones: I. Generation of T Helper, T Amplifier, and T Suppressor Clones
The idiotype network postulates that T- and B-cell clones are interconnected through idiotypic determinants borne by the immune receptor. Because the antigen receptor of T cells, like the Ig receptor of B cells, is clonally distributed, the idiotypes characterizing one clone can stimulate the proliferation of another clone bearing complementary anti-idiotypic receptors. In previous studies (1–3), we provided evidence supporting this concept by demonstrating that (allo) antigenspecific T cells trigger the production of autoantibodies and of autoreactive (i.e., AMLC-reactive) anti-idiotypic T cells. We now document the existence of anti-idiotypic T-cell clones with helper, amplifier, suppressor, and suppressor/amplifier function.
KeywordsToxicity Thymidine Allo
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