Immunoregulatory Circuits Initiated by Autoreactive T Cell Clones: I. Generation of T Helper, T Amplifier, and T Suppressor Clones

  • Niciole Suciu-Foca
  • Elaine Reed
  • Elena Cristea
  • Donald W. King

Abstract

The idiotype network postulates that T- and B-cell clones are interconnected through idiotypic determinants borne by the immune receptor. Because the antigen receptor of T cells, like the Ig receptor of B cells, is clonally distributed, the idiotypes characterizing one clone can stimulate the proliferation of another clone bearing complementary anti-idiotypic receptors. In previous studies (1–3), we provided evidence supporting this concept by demonstrating that (allo) antigenspecific T cells trigger the production of autoantibodies and of autoreactive (i.e., AMLC-reactive) anti-idiotypic T cells. We now document the existence of anti-idiotypic T-cell clones with helper, amplifier, suppressor, and suppressor/amplifier function.

Keywords

Toxicity Thymidine Allo 

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References

  1. 1.
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Niciole Suciu-Foca
    • 1
  • Elaine Reed
    • 1
  • Elena Cristea
    • 1
  • Donald W. King
    • 2
  1. 1.Department of PathologyCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA
  2. 2.Department of PathologyUniversity of ChicagoChicagoUSA

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