Abstract
The idiotype network postulates that T- and B-cell clones are interconnected through idiotypic determinants borne by the immune receptor. Because the antigen receptor of T cells, like the Ig receptor of B cells, is clonally distributed, the idiotypes characterizing one clone can stimulate the proliferation of another clone bearing complementary anti-idiotypic receptors. In previous studies (1–3), we provided evidence supporting this concept by demonstrating that (allo) antigenspecific T cells trigger the production of autoantibodies and of autoreactive (i.e., AMLC-reactive) anti-idiotypic T cells. We now document the existence of anti-idiotypic T-cell clones with helper, amplifier, suppressor, and suppressor/amplifier function.
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References
Suciu-Foca N, Reed E, Rohowsky C, Kung P, King DW. Anti-idiotypic antibodies to anti-HLA receptors induced by pregnancy. Proc Natl Acad Sci USA 1983; 80: 830–834.
Suciu-Foca N, Rohowsky C, Kung P, and King DW. Idiotypic-like determinants on human T lymphocytes alloactivated in mixed lymphocyte culture (MLC). J Exp Med 1982; 156: 283–288.
Rohowsky C, Suciu-Foca N, Kung P, Tang TF, Reed E, King DW. Suppressor T cells generated in autologous MLR with activated T lymphoblasts. Transplant Proc 1983; 15 (1): 765–770.
Suciu-Foca N, Rohowsky C, Kung P, King DW. Idiotypic receptors for soluble antigens on human T-lymphocytes clones. Human Immunol 1984; 93: 34–47.
Yoshikai Y, Yanagi Y, Suciu-Foca N, Mak TW. Presence of T cell receptor mRNA in functionally distinct T cells and elevation during intrathymic differentiation. Nature 1984; 310: 506–508.
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© 1989 Springer Science+Business Media New York
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Suciu-Foca, N., Reed, E., Cristea, E., King, D.W. (1989). Immunoregulatory Circuits Initiated by Autoreactive T Cell Clones: I. Generation of T Helper, T Amplifier, and T Suppressor Clones. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_247
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DOI: https://doi.org/10.1007/978-3-662-39946-0_247
Publisher Name: Springer, Berlin, Heidelberg
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