HLA Antigen Expression in Cardiac Transplant Biopsies: Association with Rejection and Propagation of Infiltrating Alloreactive Lymphocytes

  • Linda T. White
  • Tony R. Zerbe
  • Adriana Zeevi
  • Robert L. Hardesty
  • Bartley P. Griffith
  • Rene J. Duquesnoy

Abstract

The expression of class I and class II HLA antigens in situ was studied in serial endomyocardial biopsies of human cardiac allografts. The presence and intensity of this expression were assessed in relation to other parameters of cellular rejection: histological evidence of cellular infiltration, the IL2 facilitated growth of lymphocytes from the biopsy tissue, and donor alloreactivity of biopsy-grown cells.

Keywords

Interferon Cyclosporine Prednisone Hematoxylin Eosin 

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Linda T. White
    • 1
  • Tony R. Zerbe
    • 1
  • Adriana Zeevi
    • 1
  • Robert L. Hardesty
    • 2
  • Bartley P. Griffith
    • 2
  • Rene J. Duquesnoy
    • 1
  1. 1.Department of PathologyUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Department of SurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA

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