Abstract
HLA-B27 is a human major histocompatibility complex class I product defined by its antigenic specificity with conventional alloantisera. Detailed studies using monoclonal antibodies (MAb), cytotoxic T lymphocytes (CTL), and isoelectric focusing (IEF) gel electrophoresis have demonstrated heterogeneity in the B27 antigen. We have previously identified a unique variant molecule of B27 designated B27d which is distinguished from other B27 variants by isoelectric point, serologic reactivity, and by a cloned CTL recognition (1). In this study, we report the cloning and sequencing of the gene encoding B27d.
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References
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© 1989 Springer Science+Business Media New York
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Choo, S.Y., John, T.S., Orr, H.T., Hansen, J.A. (1989). Molecular Analysis of the Variant Alloantigen HLA-B27d Identifies a Unique Single Amino Acid Substitution. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_22
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DOI: https://doi.org/10.1007/978-3-662-39946-0_22
Publisher Name: Springer, Berlin, Heidelberg
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