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Allogeneic Rat T-Suppressor Inducer Cells with In Vivo and In Vitro Activity

  • David M. Rothstein
  • Andrew H. Frankel
  • Cheng Kwok
  • Edgar L. Milford
  • Charles B. Carpenter

Abstract

The presence of allogeneic Ag-specific T-suppressor inducer cells with in vivo activity has been demonstrated by Hutchinson (1), using a rat renal allograft model. We now demonstrate the presence of in vivo and in vitro T-suppressor inducer activity in the W3/25+ (CD4+) subset of lymphocytes from WF strain rats rejecting LEW strain heterotopic cardiac allografts transplanted 5 days previously. Adoptive transfer of 2 to 4 × 107 of these immune day 5 W3/25+ [d5 W3/25+] splenocytes, or their sonicates 7 days prior to transplantation, prolongs allograft survival two- to threefold in unmodified or irradiated hosts (200 to 300 rads). This prolongation is specific for the donor strain (Table 1).

Keywords

Adoptive Transfer Transplant Proc Mixed Lymphocyte Reaction Donor Strain Bottom Chamber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Hutchinson IV. Suppressor T cells in allogeneic models. Transplantation 1986; 41 (5): 547.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • David M. Rothstein
    • 1
  • Andrew H. Frankel
    • 1
  • Cheng Kwok
    • 1
  • Edgar L. Milford
    • 1
  • Charles B. Carpenter
    • 1
  1. 1.Laboratory of Immunogenetics and Transplantation Brigham and Women’s HospitalBostonUSA

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