Allogeneic Rat T-Suppressor Inducer Cells with In Vivo and In Vitro Activity

  • David M. Rothstein
  • Andrew H. Frankel
  • Cheng Kwok
  • Edgar L. Milford
  • Charles B. Carpenter

Abstract

The presence of allogeneic Ag-specific T-suppressor inducer cells with in vivo activity has been demonstrated by Hutchinson (1), using a rat renal allograft model. We now demonstrate the presence of in vivo and in vitro T-suppressor inducer activity in the W3/25+ (CD4+) subset of lymphocytes from WF strain rats rejecting LEW strain heterotopic cardiac allografts transplanted 5 days previously. Adoptive transfer of 2 to 4 × 107 of these immune day 5 W3/25+ [d5 W3/25+] splenocytes, or their sonicates 7 days prior to transplantation, prolongs allograft survival two- to threefold in unmodified or irradiated hosts (200 to 300 rads). This prolongation is specific for the donor strain (Table 1).

Keywords

Cyclosporine Streptomyces FK506 

References

  1. 1.
    Hutchinson IV. Suppressor T cells in allogeneic models. Transplantation 1986; 41 (5): 547.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • David M. Rothstein
    • 1
  • Andrew H. Frankel
    • 1
  • Cheng Kwok
    • 1
  • Edgar L. Milford
    • 1
  • Charles B. Carpenter
    • 1
  1. 1.Laboratory of Immunogenetics and Transplantation Brigham and Women’s HospitalBostonUSA

Personalised recommendations