Abstract
The presence of allogeneic Ag-specific T-suppressor inducer cells with in vivo activity has been demonstrated by Hutchinson (1), using a rat renal allograft model. We now demonstrate the presence of in vivo and in vitro T-suppressor inducer activity in the W3/25+ (CD4+) subset of lymphocytes from WF strain rats rejecting LEW strain heterotopic cardiac allografts transplanted 5 days previously. Adoptive transfer of 2 to 4 × 107 of these immune day 5 W3/25+ [d5 W3/25+] splenocytes, or their sonicates 7 days prior to transplantation, prolongs allograft survival two- to threefold in unmodified or irradiated hosts (200 to 300 rads). This prolongation is specific for the donor strain (Table 1).
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Hutchinson IV. Suppressor T cells in allogeneic models. Transplantation 1986; 41 (5): 547.
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© 1989 Springer Science+Business Media New York
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Rothstein, D.M., Frankel, A.H., Kwok, C., Milford, E.L., Carpenter, C.B. (1989). Allogeneic Rat T-Suppressor Inducer Cells with In Vivo and In Vitro Activity. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_210
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DOI: https://doi.org/10.1007/978-3-662-39946-0_210
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38980-5
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