The Functional Heterogeneity of HLA Class II Determinants

  • H. Festenstein
  • L. Fainboim
  • C. Navarrete
  • D. Jaraquemada
  • M. Bagnara

Abstract

The original discovery by Navarrete et al. (1) that HLA-DQ and HLA-DR specificities are differentially expressed on leukemic cells and particularly that HLA-DQ is absent from acute myeloid leukemic cells, led us to investigate whether HLA-DQ has a specific unique role in the immune response. If so, the absence of HLA-DQ on the tumor cells may be advantageous for the development of leukemia. This concept was supported by the experiments of Corte et al. (2), which showed that HLA-DQ antibody was able to prevent the in vitro generation of cytotoxic T cells. These findings were subsequently confirmed in our laboratory (3). Previous genetic experiments in the mouse in which recombinant congenic mouse strains were employed also suggested that H-2 E (the functional counterpart of HLA-DQ) is important in the generation of cytotoxic T cells.

Keywords

Lymphoma Leukemia Argentina Aires Schistosoma 

References

  1. 1.
    Navarrete C, Fainboim L, Festenstein H, Lister M, Amess J. Greaves MF. Selective expression of HLA-DR and HLA-MB antigens on acute leukemia. In: Knapp W (ed): Leukaemia markers. p 65. London: Academic Press, 1981.Google Scholar
  2. 2.
    Corte G, Moretta A, Cosulich ME, Ramarli D, Bargellesi A. A monoclonal anti-DC1 antibody selectively inhibits the generation of effector T cells mediating specific cytolytic activity. J Exp Med 1982; 156: 1539.PubMedCrossRefGoogle Scholar
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    Pawelec GP, Fernandez N, Schneider E, Festenstein H, Brooker T, Wernet P. DY determinants, possibly associated with novel class II molecules, stimulate autoreactive, CD4’ T cells with suppressive activity.Google Scholar
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    Fernandez N, Labeta ML, Festenstein H. A non-HLA-DR, DP, DQ antigen structure. In: Dupont JA (ed): Immunology of HLA. New York, Springer Verlag, 1989.Google Scholar
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    Fainboim L, Navarrete C, Festenstein H. Precursor and effector phenotypes of activated human T lymphocytes. Nature 1980; 288: 391.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • H. Festenstein
    • 1
  • L. Fainboim
    • 2
  • C. Navarrete
    • 1
  • D. Jaraquemada
    • 1
  • M. Bagnara
    • 1
  1. 1.Department of ImmunologyThe London Hospital Medical CollegeLondonUK
  2. 2.Fundacion CIMAE, Buenos Aires, Argentina and Department of ImmunologyThe London Hospital Medical CollegeLondonEngland

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