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The Functional Heterogeneity of HLA Class II Determinants

  • H. Festenstein
  • L. Fainboim
  • C. Navarrete
  • D. Jaraquemada
  • M. Bagnara

Abstract

The original discovery by Navarrete et al. (1) that HLA-DQ and HLA-DR specificities are differentially expressed on leukemic cells and particularly that HLA-DQ is absent from acute myeloid leukemic cells, led us to investigate whether HLA-DQ has a specific unique role in the immune response. If so, the absence of HLA-DQ on the tumor cells may be advantageous for the development of leukemia. This concept was supported by the experiments of Corte et al. (2), which showed that HLA-DQ antibody was able to prevent the in vitro generation of cytotoxic T cells. These findings were subsequently confirmed in our laboratory (3). Previous genetic experiments in the mouse in which recombinant congenic mouse strains were employed also suggested that H-2 E (the functional counterpart of HLA-DQ) is important in the generation of cytotoxic T cells.

Keywords

Acute Lymphoblastic Leukemia Burkitt Lymphoma Mixed Lymphocyte Culture Childhood Acute Lymphoblastic Leukemia Acute Myeloid Leukemic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Navarrete C, Fainboim L, Festenstein H, Lister M, Amess J. Greaves MF. Selective expression of HLA-DR and HLA-MB antigens on acute leukemia. In: Knapp W (ed): Leukaemia markers. p 65. London: Academic Press, 1981.Google Scholar
  2. 2.
    Corte G, Moretta A, Cosulich ME, Ramarli D, Bargellesi A. A monoclonal anti-DC1 antibody selectively inhibits the generation of effector T cells mediating specific cytolytic activity. J Exp Med 1982; 156: 1539.PubMedCrossRefGoogle Scholar
  3. 3.
    Pawelec GP, Fernandez N, Schneider E, Festenstein H, Brooker T, Wernet P. DY determinants, possibly associated with novel class II molecules, stimulate autoreactive, CD4’ T cells with suppressive activity.Google Scholar
  4. 4.
    Fernandez N, Labeta ML, Festenstein H. A non-HLA-DR, DP, DQ antigen structure. In: Dupont JA (ed): Immunology of HLA. New York, Springer Verlag, 1989.Google Scholar
  5. 5.
    Fainboim L, Navarrete C, Festenstein H. Precursor and effector phenotypes of activated human T lymphocytes. Nature 1980; 288: 391.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • H. Festenstein
    • 1
  • L. Fainboim
    • 2
  • C. Navarrete
    • 1
  • D. Jaraquemada
    • 1
  • M. Bagnara
    • 1
  1. 1.Department of ImmunologyThe London Hospital Medical CollegeLondonUK
  2. 2.Fundacion CIMAE, Buenos Aires, Argentina and Department of ImmunologyThe London Hospital Medical CollegeLondonEngland

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