Abstract
The original discovery by Navarrete et al. (1) that HLA-DQ and HLA-DR specificities are differentially expressed on leukemic cells and particularly that HLA-DQ is absent from acute myeloid leukemic cells, led us to investigate whether HLA-DQ has a specific unique role in the immune response. If so, the absence of HLA-DQ on the tumor cells may be advantageous for the development of leukemia. This concept was supported by the experiments of Corte et al. (2), which showed that HLA-DQ antibody was able to prevent the in vitro generation of cytotoxic T cells. These findings were subsequently confirmed in our laboratory (3). Previous genetic experiments in the mouse in which recombinant congenic mouse strains were employed also suggested that H-2 E (the functional counterpart of HLA-DQ) is important in the generation of cytotoxic T cells.
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References
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Corte G, Moretta A, Cosulich ME, Ramarli D, Bargellesi A. A monoclonal anti-DC1 antibody selectively inhibits the generation of effector T cells mediating specific cytolytic activity. J Exp Med 1982; 156: 1539.
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Fainboim L, Navarrete C, Festenstein H. Precursor and effector phenotypes of activated human T lymphocytes. Nature 1980; 288: 391.
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Festenstein, H., Fainboim, L., Navarrete, C., Jaraquemada, D., Bagnara, M. (1989). The Functional Heterogeneity of HLA Class II Determinants. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_201
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DOI: https://doi.org/10.1007/978-3-662-39946-0_201
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