The Functional Heterogeneity of HLA Class II Determinants
The original discovery by Navarrete et al. (1) that HLA-DQ and HLA-DR specificities are differentially expressed on leukemic cells and particularly that HLA-DQ is absent from acute myeloid leukemic cells, led us to investigate whether HLA-DQ has a specific unique role in the immune response. If so, the absence of HLA-DQ on the tumor cells may be advantageous for the development of leukemia. This concept was supported by the experiments of Corte et al. (2), which showed that HLA-DQ antibody was able to prevent the in vitro generation of cytotoxic T cells. These findings were subsequently confirmed in our laboratory (3). Previous genetic experiments in the mouse in which recombinant congenic mouse strains were employed also suggested that H-2 E (the functional counterpart of HLA-DQ) is important in the generation of cytotoxic T cells.
KeywordsAcute Lymphoblastic Leukemia Burkitt Lymphoma Mixed Lymphocyte Culture Childhood Acute Lymphoblastic Leukemia Acute Myeloid Leukemic Cell
- 1.Navarrete C, Fainboim L, Festenstein H, Lister M, Amess J. Greaves MF. Selective expression of HLA-DR and HLA-MB antigens on acute leukemia. In: Knapp W (ed): Leukaemia markers. p 65. London: Academic Press, 1981.Google Scholar
- 3.Pawelec GP, Fernandez N, Schneider E, Festenstein H, Brooker T, Wernet P. DY determinants, possibly associated with novel class II molecules, stimulate autoreactive, CD4’ T cells with suppressive activity.Google Scholar
- 4.Fernandez N, Labeta ML, Festenstein H. A non-HLA-DR, DP, DQ antigen structure. In: Dupont JA (ed): Immunology of HLA. New York, Springer Verlag, 1989.Google Scholar