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HLA-A,B,C: Patterns of Polymorphism in Peptide-Binding Proteins

  • Chapter
Immunobiology of HLA

Abstract

It is now over 50 years since Gorer’s discovery of H-2 (1,2) and 30 years since Dausset’s description of the first HLA specificity — HLA-A2 (3). Just prior to this conference, that same molecule provided the first three-dimensional structure of a transplantation antigen (4,5), enabling the synthesis and rationalization of a large body of information. The same period also witnessed the passing of Peter Medawar (6) and John Humphrey (7), pioneers in transplantation immunology and the genetics of immune responsiveness.

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Authors
  1. P. Parham
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  2. D. A. Lawlor
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  3. R. D. Salter
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  4. C. E. Lomen
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  5. P. J. Bjorkman
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  6. P. D. Ennis
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Editors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, Cornell University Graduate School of Medical Science, 10021, New York, New York, USA

    Bo Dupont (Member, Professor of Immunology) (Member, Professor of Immunology)

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Parham, P., Lawlor, D.A., Salter, R.D., Lomen, C.E., Bjorkman, P.J., Ennis, P.D. (1989). HLA-A,B,C: Patterns of Polymorphism in Peptide-Binding Proteins. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_2

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