HLA, Complotypes, and RFLP Analysis of 21-Hydroxylase (21-OH) and C4 Genes in Finnish Families with a 21-OH Deficient Patient

  • J. Partanen
  • S. Koskimies
  • I. Sipila
  • K. Simola
  • A. Hakulinen

Abstract

The 21-OHB gene encoding the enzyme 21-OH of steroid biosynthesis, and a closely-related pseudogene 21-OHA, are located in the MHC, adjacent to the C4 genes. We have performed HLA, Bf, and C4 typings, and RFLP analysis of the 21-OH and C4 genes in ten families with a patient having a 21-OH deficiency.

Keywords

Ster 

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. Partanen
    • 1
  • S. Koskimies
    • 1
  • I. Sipila
    • 2
  • K. Simola
    • 2
  • A. Hakulinen
    • 3
  1. 1.Finnish Red Cross Blood Transfusion ServiceHelsinkiFinland
  2. 2.University of HelsinkiFinland
  3. 3.University of KuopioFinland

Personalised recommendations