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DRβ Chain Polymorphism in Pemphigus Vulgaris

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Immunobiology of HLA

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Abstract

Previous studies by Amar et al (1) indicated that the risk for pemphigus vulgaris (PV) is preferentially associated with the Dw10 subtype of DR4, as well as with DRw6 in the Israeli population. This raised the possibility that third hypervariable (HVIII) region sequences, which are identical in DR4, Dw10 (2), and DRw6a (3) DRβ1 chains, might constitute a disease susceptibility epitope.

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References

  1. Amar A, Rubinstein N, Hacham-Zadeh S, Cohen O, Cohen T, Brautbar C. Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA-Dw10 and DR4? Tissue Antigens 1984; 23: 17–22.

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Author information

Authors and Affiliations

  1. Molecular Biology Unit, Department of Rheumatic Diseases, Hospital for Joint Disease, New York, NY, 10003, USA

    P. K. Gregersen, K. M. Barr, B. Sanchez, J. Silver, R. J. Winchester & A. Nunez-Roldan

  2. Department of Dermatology, New York University Medical Center, New York, NY, 10003, USA

    C. DeFeo, C. Bystryn & A. Franks

Authors
  1. P. K. Gregersen
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  2. K. M. Barr
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  3. C. DeFeo
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  4. C. Bystryn
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  5. A. Franks
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  6. B. Sanchez
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  7. J. Silver
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  8. R. J. Winchester
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  9. A. Nunez-Roldan
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Editor information

Editors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, Cornell University Graduate School of Medical Science, 10021, New York, New York, USA

    Bo Dupont (Member, Professor of Immunology) (Member, Professor of Immunology)

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© 1989 Springer Science+Business Media New York

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Gregersen, P.K. et al. (1989). DRβ Chain Polymorphism in Pemphigus Vulgaris. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_174

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  • DOI: https://doi.org/10.1007/978-3-662-39946-0_174

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38980-5

  • Online ISBN: 978-3-662-39946-0

  • eBook Packages: Springer Book Archive

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