DRβ Chain Polymorphism in Pemphigus Vulgaris
Previous studies by Amar et al (1) indicated that the risk for pemphigus vulgaris (PV) is preferentially associated with the Dw10 subtype of DR4, as well as with DRw6 in the Israeli population. This raised the possibility that third hypervariable (HVIII) region sequences, which are identical in DR4, Dw10 (2), and DRw6a (3) DRβ1 chains, might constitute a disease susceptibility epitope.
KeywordsElectrophoresis Anemia Pemphigus
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