DRβ Chain Polymorphism in Pemphigus Vulgaris

  • P. K. Gregersen
  • K. M. Barr
  • C. DeFeo
  • C. Bystryn
  • A. Franks
  • B. Sanchez
  • J. Silver
  • R. J. Winchester
  • A. Nunez-Roldan

Abstract

Previous studies by Amar et al (1) indicated that the risk for pemphigus vulgaris (PV) is preferentially associated with the Dw10 subtype of DR4, as well as with DRw6 in the Israeli population. This raised the possibility that third hypervariable (HVIII) region sequences, which are identical in DR4, Dw10 (2), and DRw6a (3) DRβ1 chains, might constitute a disease susceptibility epitope.

Keywords

Electrophoresis Anemia Pemphigus 

References

  1. 1.
    Amar A, Rubinstein N, Hacham-Zadeh S, Cohen O, Cohen T, Brautbar C. Is predisposition to pemphigus vulgaris in Jewish patients mediated by HLA-Dw10 and DR4? Tissue Antigens 1984; 23: 17–22.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • P. K. Gregersen
    • 1
  • K. M. Barr
    • 1
  • C. DeFeo
    • 2
  • C. Bystryn
    • 2
  • A. Franks
    • 2
  • B. Sanchez
    • 1
  • J. Silver
    • 1
  • R. J. Winchester
    • 1
  • A. Nunez-Roldan
    • 1
  1. 1.Molecular Biology Unit, Department of Rheumatic DiseasesHospital for Joint DiseaseNew YorkUSA
  2. 2.Department of DermatologyNew York University Medical CenterNew YorkUSA

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