Polymorphism of HLA-DR4 Associated Gene Products in Rheumatoid Arthritis

  • Jerry S. S. Lanchbury
  • Lazaros I. Sakkas
  • Steven G. E. Marsh
  • Lorna J. Kennedy
  • Julia G. Bodmer
  • Gabriel S. Panayi

Abstract

Rheumatoid arthritis (RA) is associated with the public allospecificity HLA DR4 in Caucasian and other populations (1). Since DR4 and its linked DQw3 gene products are heterogeneous (2,3), molecular studies may be useful in discriminating gene product polymorphisms more closely associated with RA. We have examined DRβ, DQβ, and DQα polymorphisms in a panel of DR4 HTC and report data on a group of DR4 homozygous RA patients.

Keywords

Arthritis Recombination eDNA Fami 

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References

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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Jerry S. S. Lanchbury
    • 1
  • Lazaros I. Sakkas
    • 1
  • Steven G. E. Marsh
    • 2
  • Lorna J. Kennedy
    • 2
  • Julia G. Bodmer
    • 2
  • Gabriel S. Panayi
    • 1
  1. 1.Molecular Immunogenetics Laboratory, Rheumatology Unit, Department of MedicineUnited Medical Schools of Guy’s & St. Thomas’ Hospitals, Guy’s HospitalLondonUK
  2. 2.Tissue Antigen LaboratoryImperial Cancer Research FundLondonUK

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