The Tumor Necrosis Factor (TNFA) and Lymphotoxin (TNFB) Genes Map Between the HLA Class III and Class I Regions

  • J. Ragoussis
  • K. Bloemer
  • E. H. Weiss
  • A. Ziegler

Abstract

The aim of this study is to map the genes for tumor necrosis factor (TNFA) and lymphotoxin (TNFB) to a distinct location in the HLA complex. TNFA and TNFB have been mapped between HLA-DR and HLA-A or cen­tromeric to HLA-DP by analyzing HLA deletion mutant cell lines (1). Pulsed field gel electrophoresis (2) and field inversion gel electrophoresis (FIGE) (3) allowed an even more precise localization between the class III and class I regions.

Keywords

Recombination Electrophoresis Nylon Kelly Dunham 

References

  1. 1.
    Spies T, Morton CC, Nedospasov SA, Fiers W, Pious D, Strominger JL. Genes for the tumor necrosis factor a and ß are linked to the major histocompatibility complex. Proc Natl Acad Sci USA 1986; 83: 8699–8702.PubMedCrossRefGoogle Scholar
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    Ragoussis J, Bloemer K, Weiss EH, Ziegler A. Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis. Immunogenetics 1988; 27: 66–69.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • J. Ragoussis
    • 1
  • K. Bloemer
    • 2
  • E. H. Weiss
    • 2
  • A. Ziegler
    • 1
  1. 1.Medizinische Klinik and Medizinisch-Naturwissenschaftliches ForschungszentrumUniversity of TübingenTübingenGermany
  2. 2.Institut für ImmunologieUniversity of MünchenMünchenGermany

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