The Tumor Necrosis Factor (TNFA) and Lymphotoxin (TNFB) Genes Map Between the HLA Class III and Class I Regions
The aim of this study is to map the genes for tumor necrosis factor (TNFA) and lymphotoxin (TNFB) to a distinct location in the HLA complex. TNFA and TNFB have been mapped between HLA-DR and HLA-A or centromeric to HLA-DP by analyzing HLA deletion mutant cell lines (1). Pulsed field gel electrophoresis (2) and field inversion gel electrophoresis (FIGE) (3) allowed an even more precise localization between the class III and class I regions.
KeywordsHuman Major Histocompatibility Complex Surface Antigen Gene Recessive Male Sterility Embryonic Lethality Gene