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The Tumor Necrosis Factor (TNFA) and Lymphotoxin (TNFB) Genes Map Between the HLA Class III and Class I Regions

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Immunobiology of HLA

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Abstract

The aim of this study is to map the genes for tumor necrosis factor (TNFA) and lymphotoxin (TNFB) to a distinct location in the HLA complex. TNFA and TNFB have been mapped between HLA-DR and HLA-A or cen­tromeric to HLA-DP by analyzing HLA deletion mutant cell lines (1). Pulsed field gel electrophoresis (2) and field inversion gel electrophoresis (FIGE) (3) allowed an even more precise localization between the class III and class I regions.

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References

  1. Spies T, Morton CC, Nedospasov SA, Fiers W, Pious D, Strominger JL. Genes for the tumor necrosis factor a and ß are linked to the major histocompatibility complex. Proc Natl Acad Sci USA 1986; 83: 8699–8702.

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  2. Dunham I, Sargent CA, Trowsdale J, Campbell DR. Molecular map of the human histocompatibility complex by pulsed-field gel electrophoresis. Proc Natl Acad Sci USA 1987; 84: 7237–7241.

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  3. Ragoussis J, Bloemer K, Weiss EH, Ziegler A. Localization of the genes for tumor necrosis factor and lymphotoxin between the HLA class I and III regions by field inversion gel electrophoresis. Immunogenetics 1988; 27: 66–69.

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Authors and Affiliations

  1. Medizinische Klinik and Medizinisch-Naturwissenschaftliches Forschungszentrum, University of Tübingen, Tübingen, Germany

    J. Ragoussis & A. Ziegler

  2. Institut für Immunologie, University of München, München, Germany

    K. Bloemer & E. H. Weiss

Authors
  1. J. Ragoussis
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  2. K. Bloemer
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  3. E. H. Weiss
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  4. A. Ziegler
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Editor information

Editors and Affiliations

  1. Sloan-Kettering Institute for Cancer Research, Cornell University Graduate School of Medical Science, 10021, New York, New York, USA

    Bo Dupont (Member, Professor of Immunology) (Member, Professor of Immunology)

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© 1989 Springer Science+Business Media New York

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Ragoussis, J., Bloemer, K., Weiss, E.H., Ziegler, A. (1989). The Tumor Necrosis Factor (TNFA) and Lymphotoxin (TNFB) Genes Map Between the HLA Class III and Class I Regions. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_11

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  • DOI: https://doi.org/10.1007/978-3-662-39946-0_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38980-5

  • Online ISBN: 978-3-662-39946-0

  • eBook Packages: Springer Book Archive

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