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Inhalation Anaesthesia Today and Tomorrow pp 31–44Cite as

The Kinetics of the Uptake and Elimination of Halothane and Enflurane

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Abstract

The general presentation of the pharmacokinetics of halothane and enflurane, using numerous mathematical models [2, 6, 9, 12, 13, 24, 25, 30, 34], like the corresponding clinical experimental investigations is based upon measurements of the inspiratory and/or end-expiratory concentration of the anaesthetic in question [8, 14, 23, 29, 31, 33], and upon determinations of the solubility of the individual inhalation anaesthetics in the various body fluids and tissues [18, 21, 22, 32]. On the other hand, measurements of the halothane or enflurane concentration in the arterial or venous blood of humans are used almost exclusively for the determination of partial pharmacokinetic or pharmacodynamic aspects [1, 3, 7, 10, 11, 16, 17, 19, 20, 26]. Only the serum half-lives calculated for halothane by Duncan and Raventos [11], which fluctuate between 3 and 45 min, are based upon nephelometric determinations of the halothane level in the venous blood.

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Authors
  1. H. Schmidt
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  2. R. Dudziak
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Editors and Affiliations

  1. Institut für Anaesthesiologie, Ludwig-Maximilians-Universität München, Klinikum Großhadern, Marchioninistraße 15, D-8000, München 70, Federal Republic of Germany

    K. Peter  & F. Jesch  & 

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© 1982 Springer-Verlag Berlin Heidelberg

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Schmidt, H., Dudziak, R. (1982). The Kinetics of the Uptake and Elimination of Halothane and Enflurane. In: Peter, K., Jesch, F. (eds) Inhalation Anaesthesia Today and Tomorrow. Anaesthesiology and Intensive Care Medicine / Anaesthesiologie und Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39944-6_6

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  • DOI: https://doi.org/10.1007/978-3-662-39944-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38979-9

  • Online ISBN: 978-3-662-39944-6

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