The Kinetics of the Uptake and Elimination of Halothane and Enflurane

  • H. Schmidt
  • R. Dudziak
Part of the Anaesthesiology and Intensive Care Medicine / Anaesthesiologie und Intensivmedizin book series (A+I)


The general presentation of the pharmacokinetics of halothane and enflurane, using numerous mathematical models [2, 6, 9, 12, 13, 24, 25, 30, 34], like the corresponding clinical experimental investigations is based upon measurements of the inspiratory and/or end-expiratory concentration of the anaesthetic in question [8, 14, 23, 29, 31, 33], and upon determinations of the solubility of the individual inhalation anaesthetics in the various body fluids and tissues [18, 21, 22, 32]. On the other hand, measurements of the halothane or enflurane concentration in the arterial or venous blood of humans are used almost exclusively for the determination of partial pharmacokinetic or pharmacodynamic aspects [1, 3, 7, 10, 11, 16, 17, 19, 20, 26]. Only the serum half-lives calculated for halothane by Duncan and Raventos [11], which fluctuate between 3 and 45 min, are based upon nephelometric determinations of the halothane level in the venous blood.


Cardiac Index Redistribution Process Inspiratory Concentration Halothane Concentration Enflurane Anaesthesia 
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© Springer-Verlag Berlin Heidelberg 1982

Authors and Affiliations

  • H. Schmidt
  • R. Dudziak

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