Abstract
This paper discusses two aspects of chromosomal replication in eukaryotes. First we consider briefly how DNA and histones associate to form the nucleosome subunits of chromatin. Second we consider how the replication of the eukaryotic genome is coordinated. Replication initiates at multiple sites on the chromosome, yet the multiple initiations are co-ordinated such that each region of DNA replicates once and only once in each cell cycle. We ask what DNA sequences specify initiation and what mechanisms prevent re-initiation.
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References
Bird AP, Taggart MH, Smith BA (1979) Cell 17: 889–901
Blumenthal AB, Kriegstein HJ, Hogness DS (1974) Cold Spring Harbor Symp Quant Biol 38: 205–223
Callan HG (1972) Proc Soc Lond [Biol] 181: 19–41.
Champoux JJ (1978) Annu Rev Biochem 47: 449–479
Crawford LV, Syrett C, Wilde A (1973) J Gen Virol 21: 515–521
Earnshaw WC, Honda BM, Laskey RA, Thomas JO (1980) Cell 21: 373–383
Fareed GC, Garon CF, Salzman NP (1972) J Virol 10: 484–491
Ford CC, Woodland HR (1975) Dev Biol 43: 189–199
Germond J-E, Rouvière-Yaniv J, Yaniv M, Brutlag D (1979) Proc Natl Acad Sci USA 76: 3779–3783
Griffin B, Fried M, Cowie A (1974) Proc Natl Acad Sci USA 71: 2077–2081
Gurdon JB, Birnstiel ML, Speight VA (1969) Biochem Biophys Acta 174: 614–628
Harland RM, Laskey RA (1980) Cell 21: 761–771
Krohne G, Franke W (1980a) Proc Natl Acad Sci USA 77: 1034–1038
Krohne G, Franke W (1980b) Exp Cell Res, in press
Laskey RA, Earnshaw WC (1980) Nature 286: 763–767
Laskey RA, Gurdon JB (1973) Eur J Biochem 37: 467–471
Laskey RA, Honda BM, Mills AD, Finch JT (1978) Nature 275: 416–420
Mandel JL, Chambon P (1979) Nucleic Acids Res 7: 2081–2103
Martin RG, Setlow VP (1980) Cell 20: 381–391
Mills AD, Laskey AD, Black P, De Robertis EM (1980) J Mol Biol 139: 561–568
Nathans D, Danna K (1972) Nature New Biol 236: 200–202
Pardoll DM, Vogelstein B, Coffey DS (1980) Cell 19: 527–536
Robberson DL, Clayton DA, Morrow JF (1974) Proc Natl Acad Sci USA 71: 4447–4451
Ruiz-Carrillo A, Jorcano JL, Eder G, Lurz R (1979) Proc Natl Acad Sci USA 76: 3284–3288
Stein A, Whitlock JP, Bina M (1979) Proc Nati Acad Sci USA 76: 5000–5004
Truett MA, Gall JG (1977) Chromosoma 64: 295–303
Vogt VM, Braun R (1977) Eur J Biochem 80: 557–566
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© 1981 Springer-Verlag Berlin Heidelberg
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Laskey, R.A., Harland, R.M., Earnshaw, W.C., Dingwall, C. (1981). Chromatin Assembly and the Co-ordination of DNA Replication in the Eukaryotic Chromosome. In: Schweiger, H.G. (eds) International Cell Biology 1980–1981. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39932-3_20
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DOI: https://doi.org/10.1007/978-3-662-39932-3_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-38972-0
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