Abstract
It is now well-established that histones interact with each other and with DNA to form nucleosomes, the invariant basic subunits of eukaryotic chromatin. Each nucleosome is a flattened disc, 55 Å × 110 Å, containing two molecules each of histones H2A, H2B, H3, and H4 in association with about 146 base pairs of DNA (for reviews, see Isenberg 1979; McGhee and Felsenfeld 1980). While our knowledge of the structure, composition, and properties of chromatin subunits is very detailed and at a high level of experimental sophistication, our understanding of the manner in which the basic chromatin fiber is folded to form higher order structures is fragmentary.
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© 1981 Springer-Verlag Berlin Heidelberg
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Hamkalo, B.A., Goldsmith, M.R., Rattner, J.B. (1981). Higher Order Structure in Chromosomes. In: Schweiger, H.G. (eds) International Cell Biology 1980–1981. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39932-3_19
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DOI: https://doi.org/10.1007/978-3-662-39932-3_19
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