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Peptid-Receptoren für Tachykinine in der Tuba uterina des Menschen

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Summary

  1. 1.

    The stimulating action of biogenic substances having pharmacological activity was quantitatively determined on the isolated infundibulum of human Fallopian tube, and compared with their action on the isolated guineapig ileum.

  2. 2.

    Oxytocin, bradykinin, kallidin, angiotensin, and noradrenaline were practically inactive. The affinity and intrinsic activity of 5-hydroxytryptamine, hist-amine, and acetylcholine were very low. Prostaglandin F2α had a high affinity but a low activity.

  3. 3.

    Affinity and activity were highest for the “tachykinins” eledoisin, physalaemin, substance P, and two synthetic analogs of eledoisin. Met-Lys-bradykinin was of lower potency. There are indications of a relationship between chemical structure of the peptides and their action on the Fallopian tube.

  4. 4.

    The sensitivity of the human Fallopian tube for tachykinins and prostaglandin F2α is so high that such compounds could play a physiological role in humoral activation of the tube during ovulation.

  5. 5.

    Corresponding work on isolated Fallopian tubes of guinea-pig, rat, rabbit, cat, pig and sheep revealed different sensitivities for biogenic stimulants. Only the rabbit Fallopian Tube reacted to eledoisin.

Zusammenfassung

  1. 1.

    Die kontrahierende Wirkung pharmakologisch aktiver biogener Substanzen auf das isolierte Infundibulum der menschlichen Tube wurde quantitativ bestimmt und mit der Wirkung auf das Meerschweinchen-Ileum verglichen.

  2. 2.

    Oxytocin, Bradykinin, Kallidin, Angiotensin und Noradrenalin waren praktisch wirkungslos. Affinität und Aktivität von 5-Hydroxytryptamin, Histamin und Acetylcholin waren sehr gering. Prostaglandin F2α hatte hohe Affinität und geringe Aktivität.

  3. 3.

    Die größte Affinität und Aktivität hatten die „Tachykinine“ Eledoisin, Physalaemin und Substanz P sowie zwei synthetische Eledoisin-Analoga. Met-Lys-Bradykinin war schwächer wirksam. Es ergaben sich Beziehungen zwischen Peptidstruktur und Wirkung auf die Tube.

  4. 4.

    Für Tachykinine und Prostaglandin F2α ist die menschliche Tube so empfindlich, daß durch solche Substanzen eine physiologische humorale Stimulierung der Tube zur Zeit der Ovulation zustande kommen könnte.

  5. 5.

    Entsprechende Untersuchungen an isolierten Tuben von Meerschweinchen, Ratte, Kaninchen, Katze, Schwein und Schaf ergaben eine uneinheitliche Empfindlichkeit für biogene Substanzen. Nur die Tube des Kaninchens reagierte auf Eledoisin.

Herrn Prof. Dr. L. Lendle zum 70. Geburtstag gewidmet

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Authors and Affiliations

  1. Institut für Pharmakologie, Medizinischen Akademie Lübeck, 2400, Lübeck, Ratzeburger Allee 160, Deutschland

    Prof. Dr. G. Zetler, D. Mönkemeier & H. Wiechell

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  1. Prof. Dr. G. Zetler
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  2. D. Mönkemeier
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  3. H. Wiechell
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Editor information

Editors and Affiliations

  1. Gießen, Deutschland

    E. Habermann

  2. Berlin, Deutschland

    H. Herken

  3. Frankfurt/M., Deutschland

    P. Holtz

  4. Graz, Österreich

    F. Lembeck

  5. Würzburg, Deutschland

    U. Trendelenburg

  6. Ulm, Deutschland

    L. Heilmeyer

  7. Göttingen, Deutschland

    L. Lendle

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Zetler, G., Mönkemeier, D., Wiechell, H. (1969). Peptid-Receptoren für Tachykinine in der Tuba uterina des Menschen. In: Habermann, E., et al. Naunyn Schmiedebergs Archiv für Pharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39718-3_8

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  • DOI: https://doi.org/10.1007/978-3-662-39718-3_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38809-9

  • Online ISBN: 978-3-662-39718-3

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