Zusammenfassung
Der Einfluß von Tabakrauch und Nicotin auf den Rhodanidstoffwechsel.
Die Thiosulfat-Sulfurtransferase (EC 2.8.1.1, früher Rhodanese genannt) wird durch Einleiten von Zigarettenrauch in Homogenate von Meerschweinchenorganen gehemmt; die Inhibitoren lassen sich sowohl in der Gasphase als auch in der Partikelphase des Rauches nachweisen. Nach Rauchexposition in vivo ist das Enzym in Meerschweinchenorganen ebenfalls gehemmt, der Rhodanidgehalt der meisten Organe ist erhöht. In Ansätzen in vitro übt Nicotin keinen Einfluß auf die Aktivität des Enzyms aus. Die Verabreichung von Nicotin in vivo jedoch führt zu einer Hemmung des Enzyms in den meisten untersuchten Organen, der Thiocyanatgehalt der meisten Organe ist nach Nicotinzufuhr erhöht.
Summary
The enzyme thiosulphate-sulphurtransferase (EC 2.8.1.1, formerly called rhodanese) of guinea pig organs is inhibited after exposure of organ homogenates to cigarette smoke. The inhibitors are present in the gaseous phase and in the particulate matter of the smoke. After smoke exposure of guinea pigs in vivo, the enzyme is also inhibited in several organs, the thiocyanate content of most of the organs is increased. Nicotine has no influence on the activity of the enzyme in vitro, but administration of nicotine to guinea pigs in vivo leads to an inhibition of the enzyme in most of the organs investigated. The thiocyanate content of several organs is elevated after nicotine administration.
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Schievelbein, H., Werle, E., Schulz, E.K., Baumeister, R. (1969). The Influence of Tobacco Smoke and Nicotine on Thiocyanate Metabolism. In: Habermann, E., et al. Naunyn Schmiedebergs Archiv für Pharmakologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39718-3_27
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