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Abstracts of the 65th congress of the German Society of Neurology pp 85–91Cite as

Cerebrospinal fluid analysis Clinical neurochemistry

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Abstract

The reported occurence of so called ‘false positives’ in a wide range of neurological diseases threatens to discredit the reputation of the oligoclonal reaction as a diagnostic test for multiple sclerosis. Selection of patients and the kind of method chosen for separation and detection of oligoclonal bands (OB) will greatly influence the results. Criteria for oligoclonal pattern evaluation have not been properly defined and currently one, two or three OB are taken for a positive rating. Because of the higher resolution the proved method of isoelectric focusing on 1 mm thick Polyacrylamide (pH 3.5–9.5) gels with silverstaining is still preferred to the often recommended separation on agarose with subsequent immunoblotting. The alleged advantage of specific detection of IgG could not be confirmed for electroblotted Polyacrylamide gels.

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Author information

Authors and Affiliations

  1. CSF-Laboratory, Neurology, Medical School Hannover, Germany

    U. Wurster, P. Lake & J. Haas

  2. Med. Zentrum für Nervenheilkunde, Neurologische Klinik (Funktionsbereich Neurochemie) der Universität, Rudolf Bultmannstr. 8, D-W-3550, Marburg, Lahn, Germany

    Rolf Hackler & Tilmann O. Kleine

  3. Department of Neurology, Technical University of Munich, Möhlstraße 28, W-8000, München 80, Germany

    M. Näher-Noé, J. Klingelhöfer, S. Freytag & B. Conrad

  4. Department of Neurology, Universitätsklinikum Rudolf Virchow, Freie Universität, Berlin, Germany

    S. Schimrigk & R. Lange

  5. Department of Neurology, Charité, Humboldt University, Berlin, Germany

    S. Schimrigk, R. Lange & H. W. Kölmel

  6. Department of Neurology, University of Saarland, D-6650, Homburg, Saar, Germany

    K.-D. Kwiet, H. Rüttinger & K. Schimrigk

  7. Neurologic clinic, St. Josef Hospital, Ruhr-University Bochum, Germany

    L. Schöls, D. Pohlau, J. Wagener, T. Postert & H. Przuntek

  8. UniversitätsnervenklinikKlinische Neurochemie, 6650, Homburg, Saar, Germany

    M. Wachinger, G. Holzer & K. Schimrigk

  9. Dept. of Neurology and Dept. of Internal Medicine, University of Rostock, Gernamy

    H. Meyer-Rienecker, E. Schmitt, E. Behm, M. Palm, B. Hitzschke, K. Lakner & G. Kundt

  10. Dept. of Neurology, Karolinska Institute, Huddinge University Hospital, Stockholm, Sweden

    E. Mix, U. Fiszer, T. Olsson, S. Fredrikson, V. Kostulas & H. Link

  11. Dept. of Neurology, Hospital for Nervous Diseases, University of Rostock, Germany

    H. Meyer-Rienecker

  12. Neurologische Universitätsklinik, Hoppe-Seyler-Strasse 3, W-7400, Tübingen, Federal Republic of Germany

    M. Schabet, H. Wiethölter, E. Dubois & J. Dichgans

  13. Institute for Clinical Chemistry, University of Munich, Marchioninistr. 15, D-8000, München 70, Germany

    M. Wick, M. Huber & A. Fateh-Moghadam

  14. Department of Neurology, University of Munich, Marchioninistr. 15, D-8000, München 70, Germany

    K. Einhäupl

  15. III Medical Department of Klinikum Großhadern, University of Munich, Marchioninistr. 15, D-8000, München 70, Germany

    U. Jehn

  16. Department of Neurology, Hospital for Nervous Diseases, University of Rostock, Germany

    R. Lehmitz

Authors
  1. U. Wurster
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  2. P. Lake
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  3. J. Haas
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  4. Rolf Hackler
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  5. Tilmann O. Kleine
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  6. M. Näher-Noé
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  7. J. Klingelhöfer
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  8. S. Freytag
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  9. B. Conrad
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  10. S. Schimrigk
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  11. R. Lange
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  12. H. W. Kölmel
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  13. K.-D. Kwiet
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  14. H. Rüttinger
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  15. K. Schimrigk
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  16. L. Schöls
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  17. D. Pohlau
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  18. J. Wagener
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  19. T. Postert
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  20. H. Przuntek
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  21. M. Wachinger
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  22. G. Holzer
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  23. K. Schimrigk
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  24. H. Meyer-Rienecker
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  25. E. Schmitt
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  26. E. Behm
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  27. M. Palm
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  28. B. Hitzschke
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  29. K. Lakner
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  30. G. Kundt
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  31. E. Mix
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  32. U. Fiszer
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  33. T. Olsson
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  34. S. Fredrikson
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  35. V. Kostulas
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  36. H. Meyer-Rienecker
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  37. H. Link
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  38. M. Schabet
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  39. H. Wiethölter
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  40. E. Dubois
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  41. J. Dichgans
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  42. M. Wick
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  43. M. Huber
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  44. K. Einhäupl
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  45. U. Jehn
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  46. A. Fateh-Moghadam
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  47. R. Lehmitz
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  48. H. Meyer-Rienecker
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© 1992 Springer-Verlag Berlin Heidelberg

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Wurster, U. et al. (1992). Cerebrospinal fluid analysis Clinical neurochemistry. In: Abstracts of the 65th congress of the German Society of Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39699-5_8

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  • DOI: https://doi.org/10.1007/978-3-662-39699-5_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-38797-9

  • Online ISBN: 978-3-662-39699-5

  • eBook Packages: Springer Book Archive

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